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In6.0
Inulin – Forschung
Hilft wahrscheinlich
136 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Inulin scheint in 13 von 14 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1995–2026 mit einer typischen Studiengröße von 49 Teilnehmenden.
Basierend auf 136 Studien · 13 Meta-Analysen · 104 RCTs · 12,902 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
13geholfen1unklar· 122 weitere ohne bewertete Effektdaten
Nach Outcome
Digestive healthVerbesserte Darmregelmäßigkeit und Mikrobiomdiversität innerhalb von 2-4 Wochen · 2-4 Wochen
Hilft wahrscheinlich86 Studien
Weight management
Hilft wahrscheinlich27 Studien
Glucose & metabolic
Hilft wahrscheinlich23 Studien
Therapeutic & clinical
Hilft vermutlich13 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung7 Studien
Liver health
Überwiegend Mechanismus / Beobachtung4 Studien
Bone health
Überwiegend Mechanismus / Beobachtung4 Studien
Joint pain & arthritis
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
InflammationVermehrung nützlicher Bakterien und verbesserte Verdauung · 2-4 Wochen
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Immune supportPräbiotische Ballaststoffe stärken die Darm-Immun-Achse über Mikrobiommodulation · 4-8 Wochen
Zu wenige bewertete Studien1 Studie
Cognitive function
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 40 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
91%
über Studien hinweg
Untersuchte Personen
13k
typische Studie: 49 Personen
Stärkste Designs
117
13 gepoolt, 104 randomisiert
Zeigte Nutzen
93%
13/14 Studien
Wie lange Studien liefen
1–4 Wochen
2
1–3 Monate
5
3+ Monate
5
Untersuchte Populationen
Adults with type 2 diabetes2
General population2
COPD patients2
Adults requiring weight management1
Aktives Forschungsgebiet
72 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199520102026
1Body weight reductionMeta-Analysen=1,184 · large study2024
Einfach gesagt: Chicory ITF supplementation may benefit weight management by reducing body weight, BMI, fat mass, waist circumference, and, to a certain extent, body fat percentage.
Reimer RA et al. · The American journal of clinical nutrition (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Chicory ITF significantly reduced body weight [mean difference (MD): -0.97 kg; 95% CI: -1.34, -0.59); n = 1184] compared with placebo.
Except for considerable heterogeneity in body weight (I2: 73%) and body fat percentage (I2: 75%), all other outcomes had negligible to moderate heterogeneity.
Significant reduction in body weight, BMI, and waist circumference was evident irrespective of participants' health status.
2HbA1c reductionMeta-Analysen=2,685 · very large study2023
Einfach gesagt: Galactomannans were the most effective dietary fiber for reducing the levels of HbA1c, fasting blood glucose, triglycerides, and LDL cholesterol in patients with type 2 diabetes.
Juhász AE et al. · The American journal of clinical nutrition (2023)
Galactomannans had the highest effect on reducing the levels of HbA1c (SUCRA: 92.33%) and fasting blood glucose (SUCRA: 85.92%).
With regard to fasting insulin level, HOMA-IR, β-glucans (SUCRA: 73.45%), and psyllium (SUCRA: 96.67%) were the most effective interventions.
Galactomannans were ranked first in reducing the levels of triglycerides (SUCRA: 82.77%) and LDL cholesterol (SUCRA: 86.56%).
4Bifidobacterium abundanceMeta-Analysen=2,525 · very large study2023
Einfach gesagt: Chicory-derived inulin-type fructans at a dose of 3-20 g/day significantly increased Bifidobacterium abundance in participants with an age range from 0 to 83 years (standardized mean difference: 0.83, 95% CI: 0.58-1.08; p < 0.01; 50 studies; 2525 participants).
Nagy DU et al. · Critical reviews in food science and nutrition (2023)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Chicory-derived inulin-type fructans at a dose of 3-20 g/day significantly increased Bifidobacterium abundance (standardized mean difference: 0.83, 95% CI: 0.58-1.08; p < 0.01; 50 studies; 2525 participants).
Significant bifidogenic effects were observed in healthy individuals and in populations with health impairments, except gastrointestinal disorders.
Significant beneficial effects on bowel function parameters were observed in healthy subjects.
Einfach gesagt: FMT and multistrain probiotics showed superior efficacy in UC.
Zhang T et al. · Journal of gastroenterology and hepatology (2025)
FMT and multistrain probiotics showed superior efficacy in UC.
However, the efficacy of MTTs varies among different IBD subtypes and disease stages; thus, the personalized treatment strategies of MTTs are necessary.
10Clinical outcomes in cystic fibrosisSystematische Übersicht2023
Einfach gesagt: This review did not find any evidence for the use of prebiotics in people with CF.
Williams NC et al. · The Cochrane database of systematic reviews (2023)
This review did not find any evidence for the use of prebiotics in people with CF.
Until such evidence is available, it is reasonable for clinicians to follow any local guidelines and to discuss the use of dietary prebiotics with their patients.
Large and robust RCTs assessing the dietary prebiotics of inulin or galacto-oligosaccharides or fructo-oligosaccharides, or any combination of these, are needed.
Einfach gesagt: We found little evidence to suggest that prebiotic or probiotic supplements are associated with significant decreases in CRC occurrence.
Kim CE et al. · Nutrients (2022)
We found little evidence to suggest that prebiotic or probiotic supplements are associated with significant decreases in CRC occurrence.
Prebiotic supplementation was not associated with colorectal neoplasia risk.
There was some evidence that probiotic supplementation may be associated with lower risk of adenomas but not with CRC incidence.
Einfach gesagt: Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.
Morsali M et al. · Journal of research in health sciences (2021)
Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.
Einfach gesagt: The meta-analysis indicated that the numbers of subjects with ≥1 RTI were reduced with prebiotic (OR, 0.73; 95% CI: 0.62-0.86; P = 0.0002; n = 17) and synbiotic (OR, 0.75; 95% CI: 0.65-0.87; P = 0....
Williams LM et al. · Advances in nutrition (Bethesda, Md.) (2022)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
The meta-analysis indicated that the numbers of subjects with ≥1 RTI were reduced with prebiotic (OR, 0.73; 95% CI: 0.62-0.86; P = 0.0002; n = 17) and synbiotic (OR, 0.75; 95% CI: 0.65-0.87; P = 0.0001; n = 9) supplementation compared to placebo.
Further, NK cell activity was increased with synbiotic (standardized mean difference, 0.74; 95% CI: 0.42-1.06; P < 0.0001, n = 3) supplementation.
This review provides evidence that prebiotic, specifically oligosaccharide, supplementation may play a protective role in RTIs in infants and children.
Einfach gesagt: Some prebiotics and synbiotics may have immunomodulatory action, however, more randomized controlled trials are needed to support the clinical use of inulin-type fructans, galacto-oligosaccharides or related synbiotics for the treatment of metabolic endotoxaemia or low-grade inflammation in overweight/obese people.
Fernandes R et al. · Clinical nutrition (Edinburgh, Scotland) (2017)
Einfach gesagt: In summary, the use of ITF may have benefits for LDL-c reduction across all study populations, whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup.
Liu F et al. · European journal of clinical nutrition (2017)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
In the overall analysis, the supplementation of ITF reduced only the low density lipoprotein-cholesterol (LDL-c) (mean difference (MD): -0.15; 95% confidence interval (CI): -0.29, -0.02; P=0.03) without affecting the other endpoints.
Within the T2DM subgroup analysis, ITF supplementation was positively associated with a decreased fasting insulin concentration (MD: -4.01; 95% CI: -5.92, -2.09; P<0.0001) and increased high density lipoprotein-cholesterol (HDL-c) (MD: 0.07; 95% CI: 0, 0.14; P=0.05).
Moreover, a reduced fasting glucose tendency was identified only in the T2DM subgroup (MD: -0.42; 95% CI: -0.90, 0.06; P=0.09).
16Short-chain fatty acid productionSystematische Übersichtn=11 · very small study2022
Einfach gesagt: Future studies are needed to better elucidate the relationship between DFs and gut microbiota in terms of SCFA production and impact on health-related markers.
Vinelli V et al. · Nutrients (2022)
Regarding the results obtained on the ability of fiber to modulate total SCFAs, seven studies reported a significant increase, while no significant changes were reported in five studies, depending on the analytical methodology used.
Overall, these results underline that, although affecting microbiota composition and derived metabolites, DFs do not produce univocal significant increase in SCFA levels in apparently healthy adults.
The effect of DF interventions on the SCFA profile seemed to be strictly dependent on the dose and the type and structure of DFs.
18Gut health modulationÜbersichtn=22 · very small study2026
Einfach gesagt: Prebiotics are effective modulators of gut health, driving clinical benefits through selective microbial fermentation and SCFA production.
Monteiro CRAV et al. · Nutrients (2026)
Prebiotics are effective modulators of gut health, driving clinical benefits through selective microbial fermentation and SCFA production.
The documented heterogeneity and variability highlight the need for future research to focus on personalized nutritional strategies.
Key priorities include standardizing intervention protocols, elucidating dose-response relationships, integrating multi-omics data to link taxonomy to function, and exploring novel applications such as synbiotic formulations and gut-brain axis modulation.
19Inflammatory markers in diabetesMeta-Analysen=46 · small study2025
Einfach gesagt: Strain- and dose-standardized RCTs should confirm impacts on glycemic and cardiometabolic outcomes.
Xie Y, Zheng Y, Jiang F, Cai X. · Frontiers in cellular and infection microbiology (2025)
Groß Nutzen
← SchlechterKein EffektBesser →
Results Probiotic/synbiotic interventions led to significant reductions in CRP (SMD = -0.54), IL-6 (SMD = -0.41), and TNF-α (SMD = -0.48), along with an increase in IL-10 (SMD = +0.38).
SCFA levels rose significantly, with butyrate showing the strongest effect (SMD = +0.46).
Multi-strain and synbiotic interventions were more effective than single-strain or probiotic-only formulations.
20Pain and pain sensitivity in knee osteoarthritisRCTn=117 · medium study2026
Einfach gesagt: Only inulin improved pain sensitivity and grip strength, the latter paralleled by increased GLP-1, and had much higher rates of retention compared to PSE.
Kouraki A et al. · Nutrients (2026)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Results: A total of 117 participants (58.1% female; mean ± SD age = 67.5 ± 9.4 years; BMI = 29.5 ± 5.3 kg/m2; NRS = 3.96 ± 2.67) completed the trial.
Pain improved with inulin (baseline-adjusted between-group mean difference (Δ) = -1.11 [95%CI -2.18, -0.04], p = 0.045) and PSE (Δ = -1.55 [95%CI -2.52, -0.58], p = 0.002) compared to placebo, with no synergistic effect.
PSE improved TUG (p = 0.02) and 30-CST (p = 0.0004), while inulin improved grip strength (p = 0.002), pressure pain thresholds (p = 0.009) and temporal summation (p = 0.025) compared to placebo and had significantly lower dropout rates (3.6%) compared with PSE (21% p < 0.01).