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Ktz4.0

Ketoconazole (Nizoral) Research

Mostly mechanism / observational

181 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Ketoconazole (Nizoral) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 1983–2025.

Based on 181 studies · 3 meta-analyses · 170 RCTs

Confidence

High confidence

By outcome

Seborrheic dermatitis & dandruff
Mostly mechanism / observational43 studies
Therapeutic & clinical
Mostly mechanism / observational19 studies
Hair & scalp
Mostly mechanism / observational11 studies
Safety profile
Mostly mechanism / observational4 studies
Liver health
Too few graded studies2 studies

Slowing down

Only 2 studies in the last 5 years · Latest meta-analysis: 2020

198320042025

1Meta-Analysis2020

Xue T, Yang T, Chen C, Wu S, Li M, Ma L · J Clin Pharm Ther (2020)

Ketoconazole (Nizoral) Research

Mostly mechanism / observational

Efficacy and safety of ketoconazole combined with calmodulin inhibitor in solid organ transplantation: A systematic review and meta-analysis.

Ketoconazole gel 2% in the treatment of moderate to severe seborrheic dermatitis.

Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.

Topical ketoconazole: a systematic review of current dermatological applications and future developments.

Seborrhoeic dermatitis.

Ketoconazole for the Treatment of Docetaxel-Naïve Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Systematic Review.

Trial of ketoconazole in non-invasive pulmonary aspergillosis.

A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff.

A randomized double-blind, non-inferiority Phase II trial, comparing dapaconazole tosylate 2% cream with ketoconazole 2% cream in the treatment of Pityriasis versicolor.

Effect of ketoconazole on plasma sex hormones, lipids, lipoproteins, and apolipoproteins in hyperandrogenic women.

[A double-blind placebo-controlled study of a 2 percent foaming lotion of ketoconazole in a single application in the treatment of pityriasis versicolor].

Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study.

Bioequivalence evaluation of two brands of ketoconazole tablets (Onofin-K and Nizoral) in a healthy female Mexican population.

Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts.

[Ketoconazole and clindamycin efficacy vs oral clindamycin in premature membranes rupture prevention].

A preliminary report of diltiazem and ketoconazole. Their cyclosporine-sparing effect and impact on transplant outcome.

A randomized, phase II trial of ketoconazole plus alendronate versus ketoconazole alone in patients with androgen independent prostate cancer and bone metastases.

Fluconazole versus ketoconazole in the treatment of tinea versicolor.

Amphotericin B vs high-dose ketoconazole for empirical antifungal therapy among febrile, granulocytopenic cancer patients. A prospective, randomized study.

Fluconazole versus ketoconazole in the treatment of oropharyngeal candidiasis in HIV-infected children. Multicentre Study Group.