Kisspeptin Research

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy.

Abbara A, Jayasena CN, Christopoulos G, Narayanaswamy S, Izzi-Engbeaya C, Nijher GM · J Clin Endocrinol Metab (2015)

The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.

Izzi-Engbeaya C, Comninos AN, Clarke SA, Jomard A, Yang L, Jones S · Diabetes Obes Metab (2018)

Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome.

Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA · Hum Reprod (2020)

The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men.

Yang L, Demetriou L, Wall MB, Mills EG, Wing VC, Thurston L · J Clin Endocrinol Metab (2021)

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.

Abbara A, Clarke S, Islam R, Prague JK, Comninos AN, Narayanaswamy S · Hum Reprod (2017)

Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men.

Yang L, Demetriou L, Wall MB, Mills EG, Zargaran D, Sykes M · JCI Insight (2020)

Kisspeptin modulates sexual and emotional brain processing in humans.

Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S · J Clin Invest (2017)

Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals.

Abbara A, Ufer M, Voors-Pette C, Berman L, Ezzati M, Wu R · Fertil Steril (2024)

Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies.

MacLean DB, Matsui H, Suri A, Neuwirth R, Colombel M · J Clin Endocrinol Metab (2014)

Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-683, an investigational metastin analogue in healthy men.

Scott G, Ahmad I, Howard K, MacLean D, Oliva C, Warrington S · Br J Clin Pharmacol (2013)

Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions.

Comninos AN, Demetriou L, Wall MB, Shah AJ, Clarke SA, Narayanaswamy S · JCI Insight (2018)

Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women.

Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA · J Clin Endocrinol Metab (2016)

Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

In plain English: Kisspeptin administration substantially modulates sexual brain processing in men with HSDD, with associated increases in penile tumescence and behavioral measures of sexual desire.

Mills EG, Ertl N, Wall MB, Thurston L, Yang L, Abbara A, Goldmeier D, Comninos AN, Dhillo WS, et al. · JAMA Netw Open (2023)

Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.

In plain English: Kisspeptin administration resulted in modulations in sexual and facial attraction brain processing ... Kisspeptin was well-tolerated with no reported adverse effects.

Thurston L, Hunjan T, Ertl N, Wall MB, Mills EG, Suladze S, Patel B, Alexander EC, Bassett PA, Rabiner EA, Goldmeier D, Abbara A, Comninos AN, Dhillo WS. · JAMA Netw Open (2022)

Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.

In plain English: Acute administration of kisspeptin to women with infertility due to HA potently stimulates gonadotropin release, but chronic administration of kisspeptin results in desensitization to its effects.

Jayasena CN, Nijher GM, Chaudhri OB, Murphy KG, Ghatei MA, Bloom SR, Dhillo WS, et al. · J Clin Endocrinol Metab (2009)

Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism.

In plain English: KP54 fully discriminated men with CHH from healthy men ... could be used to specifically interrogate hypothalamic GnRH neuronal function.

Abbara A, Eng PC, Phylactou M, Clarke SA, Mills E, Jayasena CN, Comninos AN, Quinton R, Pitteloud N, Dhillo WS, et al. · Neuroendocrinology (2021)

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour.

In plain English: kisspeptin is implicated in the control of reproductive behaviour in animals, modulation of human sexual and emotional brain processing, and has antidepressive and fear-suppressing effects.

Mills EG, Izzi-Engbeaya C, Abbara A, Comninos AN, Dhillo WS. · Nat Rev Endocrinol (2021)

Endocrine Requirements for Oocyte Maturation Following hCG, GnRH Agonist, and Kisspeptin During IVF Treatment.

In plain English: The endocrine response during oocyte maturation significantly differed by each trigger ... inform the design of future precision-triggering protocols.

Abbara A, Hunjan T, Ho VNA, Clarke SA, Comninos AN, Trew GH, Humaidan P, Vuong LN, Dhillo WS, et al. · Front Endocrinol (Lausanne) (2020)

Divergent responses to kisspeptin in children with delayed puberty.

In plain English: Children with delayed/stalled puberty showed a wide range of responses, with some showing a robust response and others showing little to no response.

Chan YM, Lippincott MF, Kusa TO, Seminara SB. · JCI Insight (2018)

The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans.

In plain English: Kisspeptin-10 stimulates gonadotropin release in men as well as women during the preovulatory phase of menstrual cycle but fails to stimulate gonadotropin release in women during the follicular phase.

Jayasena CN, Nijher GM, Comninos AN, Abbara A, Murphy KG, Ghatei MA, Bloom SR, Dhillo WS, et al. · J Clin Endocrinol Metab (2011)