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Lgn6.0

L-Glutamine Research

Likely helps

311 peer-reviewed studies

What the evidence says

Likely helps

L-Glutamine appears to help in 3 of 3 studies with measurable effects — the evidence leans clearly favourable.

Most evidence is from high-quality meta-analyses and randomised trials published 1989–2026 with a typical study size of 46 participants.

Based on 311 studies · 32 meta-analyses · 256 RCTs · 3,086 total participants

Confidence

High confidence

What the studies found

3helped· 308 more without graded effect data

By outcome

Therapeutic & clinical
Mostly mechanism / observational91 studies
RecoveryA meta-analysis found no effect on athletic performance or body composition; recovery benefit is unproven · 1-2 weeks
Mostly mechanism / observational18 studies
Digestive healthMay aid gut-lining repair; human permeability data are limited and one exertional-stress trial showed no benefit · 4-8 weeks
Mostly mechanism / observational14 studies
Sickle cell disease
Mostly mechanism / observational8 studies
InflammationMay support intestinal barrier integrity (mostly preclinical evidence) · 2-4 weeks
Mostly mechanism / observational7 studies
Immune supportMixed evidence: one small athlete trial showed benefit, but a meta-analysis found no overall immune effect · 2-4 weeks
Mostly mechanism / observational6 studies
Lean body mass & muscle growth
Mostly mechanism / observational6 studies
Safety profile
Mostly mechanism / observational5 studies
Endurance & exercise performance
Mostly mechanism / observational4 studies
Depression & mood
Mostly mechanism / observational4 studies

By the numbers

Pulled from 11 studies with measurable effects

Likely real effects

100%

across studies

People studied

3,086

typical study: 46 people

Strongest designs

288

32 pooled, 256 randomised

Showed benefit

100%

3/3 studies

How long studies ran

1–4 weeks

3+ months

Populations Studied

Patients with sickle cell disease1

Major depressive disorder patients1

COVID-19 patients1

Patients undergoing hip and knee replacement surgery1

Steady research

42 studies in the last 5 years · Latest meta-analysis: 2026

198920072026

1Systematic ReviewCited 99×n=2,015 · very large study2016

Electroacupuncture was not superior to placebo.

Brami C et al. · Critical reviews in oncology/hematology (2016)

Electroacupuncture was not superior to placebo.
No RCTs were published regarding other complementary therapies, although some studies mention positive incidental findings.
Natural products and complementary therapies deserve further investigation, given the lack of effective CIPN interventions.

L-Glutamine Research

Likely helps

By the numbers

Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review

Effect of Perioperative Glutamine-Enhanced Parenteral Nutrition on Short-Term Outcomes in Colorectal Cancer Patients Undergoing Radical Resection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Glutamine prevents diarrhea in colorectal cancer patients undergoing chemotherapy or chemoradiotherapy: a meta-analysis.

Glutamine enteral therapy for critically ill adult patients: An updated meta-analysis of randomized controlled trials and trial sequential analysis.

Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis.

A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults.

The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis.

Effect of glutamine supplementation on inflammatory markers in critically ill patients supported with enteral or parenteral feeding.

Effect of glutamine supplementation on cardiometabolic risk factors and inflammatory markers: a systematic review and meta-analysis.

The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.

The effect of glutamine supplementation on athletic performance, body composition, and immune function: A systematic review and a meta-analysis of clinical trials.

Glutamine dipeptide-supplemented parenteral nutrition improves the clinical outcomes of critically ill patients: A systematic evaluation of randomised controlled trials.

Is there a role for glutamine supplementation in the management of acute pancreatitis?

Efficacy of glutamine-enriched enteral feeding formulae in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.

Glutamine supplementation to prevent morbidity and mortality in preterm infants.

Glutamine Supplementation in Intensive Care Patients: A Meta-Analysis of Randomized Clinical Trials.

Antioxidants as a treatment for acute pancreatitis: A meta-analysis.

Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis.

Effect of glutamine dipeptide supplementation on primary outcomes for elective major surgery: systematic review and meta-analysis.

The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials.