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Studies
Lgn6.0
L-Glutamine Research
Too few graded studies
313 peer-reviewed studies
What the evidence says
Too few graded studies
L-Glutamine doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1989–2026 with a typical study size of 60 participants.
Based on 313 studies · 31 meta-analyses · 255 RCTs · 541 total participants
Confidence
High confidence
What the studies found
1helped· 312 more without graded effect data
By outcome
Therapeutic & clinical
Too few graded studies91 studies
RecoveryA meta-analysis found no effect on athletic performance or body composition; recovery benefit is unproven · 1-2 weeks
Too few graded studies18 studies
Digestive healthMay aid gut-lining repair; human permeability data are limited and one exertional-stress trial showed no benefit · 4-8 weeks
Too few graded studies14 studies
Sickle cell disease
Too few graded studies10 studies
InflammationMeta-analyses report modest CRP reductions, mostly in clinical and critically ill populations, with no consistent effect on IL-6 or TNF-a · 2-4 weeks
Too few graded studies7 studies
Lean body mass & muscle growth
Too few graded studies6 studies
Immune supportMixed evidence: one small athlete trial showed benefit, but a meta-analysis found no overall immune effect · 2-4 weeks
Too few graded studies5 studies
Safety profile
Too few graded studies5 studies
Depression & mood
Too few graded studies4 studies
Endurance & exercise performance
Too few graded studies3 studies
By the numbers
Pulled from 10 studies with measurable effects
Likely real effects
100%
across studies
People studied
541
typical study: 60 people
Strongest designs
286
31 pooled, 255 randomised
Showed benefit
100%
1/1 studies
How long studies ran
1–4 weeks
2
3+ months
1
Populations Studied
Patients with sickle cell disease1
Major depressive disorder patients1
COVID-19 patients1
Patients undergoing hip and knee replacement surgery1
Steady research
47 studies in the last 5 years · Latest meta-analysis: 2026
198920072026
1Systematic ReviewCited 100×2016
In plain English: Electroacupuncture was not superior to placebo.
Brami C et al. · Critical reviews in oncology/hematology (2016)
Electroacupuncture was not superior to placebo.
No RCTs were published regarding other complementary therapies, although some studies mention positive incidental findings.
Natural products and complementary therapies deserve further investigation, given the lack of effective CIPN interventions.