1Meta-Analysis2021
Qin Y · J Gynecol Obstet Hum Reprod (2021)
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95 peer-reviewed studies
What the evidence says
Most Letrozole studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2003–2026 with a typical study size of 82 participants.
Based on 95 studies · 21 meta-analyses · 69 RCTs · 5,580 total participants
Confidence
High confidenceBy outcome
55 studies in the last 5 years · Latest meta-analysis: 2026
Qin Y · J Gynecol Obstet Hum Reprod (2021)
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Tang X, Huang Q, Wang C, Zhang D, Dong S, Yu C · Front Endocrinol (Lausanne) (2021)
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Baradwan S, Al-Shalhoub F, Alshahrani MS, Himayda S, AlSghan R, Sabban H · Hormones (Athens) (2024)
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Zhao J, Xu B, Huang X, Yan Y, Li Y · Reprod Health (2020)
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Dutta D, Singla R, Surana V, Sharma M · J Clin Res Pediatr Endocrinol (2022)
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Tarafdari A, Keikha F, Asadi F, Hantoushzadeh S, Gargari OK, Forouzin M · Reprod Sci (2024)
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Zeng MF, Zhou X, Duan JL · Gynecol Endocrinol (2021)
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Sun S, Zhang H, Zhong P, Xu Z · Biomed Res Int (2021)
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Miller KAR, de Castro Martin GC, Servidoni ACP, Dos Santos PL, Lemos MJ, Pereira H · Eur J Contracept Reprod Health Care (2026)
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Bülow NS, Wissing ML, Macklon N, Pinborg A, Løssl K · Hum Reprod Update (2025)
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Cai T, Al-Jubairi NN, Santos HO, de Souza IGO, Chen Y · Steroids (2021)
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Etrusco A, D'Amato A, Agrifoglio V, Laganà AS, Andrisani A, Cantatore C · Eur J Obstet Gynecol Reprod Biol (2025)
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Laganà AS, Etrusco A, Haydamous J, Semaan S, Agrifoglio V, Chiantera V · Eur J Obstet Gynecol Reprod Biol (2024)
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Zhang T, Feng F, Yao Y, Qi L, Tian J, Zhou C · J Cell Physiol (2019)
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Marchetti C, De Felice F, Ergasti R, Scambia G, Fagotti A · Int J Gynecol Cancer (2020)
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Nash CM, Philp L, Shah P, Murphy KE · Contraception (2018)
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In plain English: Our results support lower-dose combination therapy for improved ovulation, follicle count, and pregnancy outcomes while reducing miscarriage risk.
Alhebshi ZA, Alqarni DH, Najjar AA, Alshalahi SS, Alhatlani RA, Jamal A, Wasaya HMI, Almehmadi M, Alrafi MA, AlHabardi N. · Reproductive sciences (Thousand Oaks, Calif.) (2025)
Allameh Z, Goharian M, Eslamian M · Int J Gynaecol Obstet (2020)
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van 't Veer LJ, Meershoek-Klein Kranenbarg E, Duijm-de Carpentier M, Van de Velde CJH, Kleijn M, Dreezen C · JAMA Netw Open (2024)
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Elfrink EM, Johannsen ML, Pedersen KM, la Cour Poulsen L, Zheng M, Grøndahl ML · J Assist Reprod Genet (2026)
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