Lithium Orotate Research

Bipolar Disorder and Manic-Like Symptoms in Alzheimer's, Vascular and Frontotemporal Dementia: A Systematic Review.

Elefante C, Brancati GE, Torrigiani S, Amadori S, Ricciardulli S, Pistolesi G · Curr Neuropharmacol (2023)

Psychiatric benefits of lithium in water supplies may be due to protection from the neurotoxicity of lead exposure.

Brown EE, Gerretsen P, Pollock B, Graff-Guerrero A · Med Hypotheses (2018)

Comparative efficacy, tolerability and acceptability of donanemab, lecanemab, aducanumab and lithium on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysis

In plain English: Low-dose lithium may be safer than aducanumab, lecanemab and donanemab.

Terao I, Kodama W. · Ageing research reviews (2024)

Identifying the neuropsychiatric health effects of low-dose lithium interventions: A systematic review.

Strawbridge R, Kerr-Gaffney J, Bessa G, Loschi G, Freitas HLO, Pires H · Neurosci Biobehav Rev (2023)

Standard and trace-dose lithium: a systematic review of dementia prevention and other behavioral benefits.

Mauer S, Vergne D, Ghaemi SN · Aust N Z J Psychiatry (2014)

Adjunct low dose lithium carbonate in treatment-resistant depression: a placebo-controlled study.

Zusky PM, Biederman J, Rosenbaum JF, Manschreck TC, Gross CC, Weilberg JB · J Clin Psychopharmacol (1988)

The efficacy of low-dose lithium: clinical, psychological and biological correlates.

Abou-Saleh MT, Coppen A · J Psychiatr Res (1989)

Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial.

Devanand DP, Crocco E, Forester BP, Husain MM, Lee S, Vahia IV · Am J Geriatr Psychiatry (2022)

[Pharmacokinetics of low-dose lithium in healthy volunteers].

Allain P, Le Bouil A, Turcant A, Molinier P, Armand P, Andrianiriana F · Therapie (1994)

Long-term effects of cognitive-behavioural therapy and lithium therapy on depression in the elderly.

Wilson KC, Scott M, Abou-Saleh M, Burns R, Copeland JR · Br J Psychiatry (1995)

Long-term, low-dose lithium treatment does not impair renal function in the elderly: a 2-year randomized, placebo-controlled trial followed by single-blind extension.

Aprahamian I, Santos FS, dos Santos B, Talib L, Diniz BS, Radanovic M · J Clin Psychiatry (2014)

Prophylactic therapy with lithium in elderly patients with unipolar major depression.

Wilkinson D, Holmes C, Woolford J, Stammers S, North J · Int J Geriatr Psychiatry (2002)

Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation.

Deliyannides DA, Graff JA, Niño I, Lee S, Husain MM, Forester BP · Int J Geriatr Psychiatry (2023)

Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data.

Perlis RH, Sachs GS, Lafer B, Otto MW, Faraone SV, Kane JM · Am J Psychiatry (2002)

An exploratory study of responses to low-dose lithium in African Americans and Hispanics.

Gonzalez Arnold J, Salcedo S, Ketter TA, Calabrese JR, Rabideau DJ, Nierenberg AA · J Affect Disord (2015)

Long-term lithium treatment reduces glucose metabolism in the cerebellum and hippocampus of nondemented older adults: an [¹⁸F]FDG-PET study.

Forlenza OV, Coutinho AM, Aprahamian I, Prando S, Mendes LL, Diniz BS · ACS Chem Neurosci (2014)

The effects of Lithium on Beta-amyloid deposition and tau phosphorylation: A systematic review

In plain English: Further research should seek to replicate similar findings in larger samples and explore lithium's optimal dosage range in promoting intracerebral amyloid clearance.

Xiao K, Sayed H, Xing J, Zhang XY, Ai J, Kirichek E, Le GH, Wong S, Valentino K, Teopiz KM, Vinberg M, Rosenblat JD, Lo HKY, Zhang MC, McIntyre RS. · Journal of affective disorders (2026)

Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial

In plain English: This pilot randomized clinical trial established feasibility, confirmed safety and tolerability, and generated effect size estimates for future trials of low-dose lithium in MCI.

Gildengers AG et al. · JAMA neurology (2026)

Lithium and long-term cognitive outcomes in bipolar disorder and early dementia: a systematic review

In plain English: Future adequately powered RCTs with cognition as a primary endpoint, functional measures, and biomarker outcomes are warranted to clarify lithium's role as a maintenance treatment in psychiatric disorders and its potential neuroprotective effects in neurodegenerative diseases.

Deng R, Shargorodsky A, Teopiz K, Dri CE, Wong S, Le GH, Zheng YJ, McIntyre RS. · CNS spectrums (2026)

An open label pilot trial of low-dose lithium for young people at ultra-high risk for psychosis

In plain English: A definitive larger trial is needed to determine the efficacy of lithium in this cohort.

Rice SM, Nelson B, Amminger GP, Francey SM, Phillips LJ, Simmons MB, Ross M, Yuen HP, Yung AR, O'Gorman K, McGorry PD, Wood SJ, Berger GE. · Early intervention in psychiatry (2024)