1Systematic Review2023
Elefante C, Brancati GE, Torrigiani S, Amadori S, Ricciardulli S, Pistolesi G · Curr Neuropharmacol (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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32 peer-reviewed studies
What the evidence says
Most Lithium Orotate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1988–2026 with a typical study size of 60 participants.
Based on 32 studies · 2 meta-analyses · 13 RCTs · 6,933 total participants
Confidence
High confidenceBy outcome
20 studies in the last 5 years · Latest meta-analysis: 2024
Elefante C, Brancati GE, Torrigiani S, Amadori S, Ricciardulli S, Pistolesi G · Curr Neuropharmacol (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Brown EE, Gerretsen P, Pollock B, Graff-Guerrero A · Med Hypotheses (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Low-dose lithium may be safer than aducanumab, lecanemab and donanemab.
Terao I, Kodama W. · Ageing research reviews (2024)
Strawbridge R, Kerr-Gaffney J, Bessa G, Loschi G, Freitas HLO, Pires H · Neurosci Biobehav Rev (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mauer S, Vergne D, Ghaemi SN · Aust N Z J Psychiatry (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Zusky PM, Biederman J, Rosenbaum JF, Manschreck TC, Gross CC, Weilberg JB · J Clin Psychopharmacol (1988)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Abou-Saleh MT, Coppen A · J Psychiatr Res (1989)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Devanand DP, Crocco E, Forester BP, Husain MM, Lee S, Vahia IV · Am J Geriatr Psychiatry (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Allain P, Le Bouil A, Turcant A, Molinier P, Armand P, Andrianiriana F · Therapie (1994)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Wilson KC, Scott M, Abou-Saleh M, Burns R, Copeland JR · Br J Psychiatry (1995)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Aprahamian I, Santos FS, dos Santos B, Talib L, Diniz BS, Radanovic M · J Clin Psychiatry (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Wilkinson D, Holmes C, Woolford J, Stammers S, North J · Int J Geriatr Psychiatry (2002)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Deliyannides DA, Graff JA, Niño I, Lee S, Husain MM, Forester BP · Int J Geriatr Psychiatry (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Perlis RH, Sachs GS, Lafer B, Otto MW, Faraone SV, Kane JM · Am J Psychiatry (2002)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Gonzalez Arnold J, Salcedo S, Ketter TA, Calabrese JR, Rabideau DJ, Nierenberg AA · J Affect Disord (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Forlenza OV, Coutinho AM, Aprahamian I, Prando S, Mendes LL, Diniz BS · ACS Chem Neurosci (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Further research should seek to replicate similar findings in larger samples and explore lithium's optimal dosage range in promoting intracerebral amyloid clearance.
Xiao K, Sayed H, Xing J, Zhang XY, Ai J, Kirichek E, Le GH, Wong S, Valentino K, Teopiz KM, Vinberg M, Rosenblat JD, Lo HKY, Zhang MC, McIntyre RS. · Journal of affective disorders (2026)
In plain English: This pilot randomized clinical trial established feasibility, confirmed safety and tolerability, and generated effect size estimates for future trials of low-dose lithium in MCI.
Gildengers AG et al. · JAMA neurology (2026)
In plain English: Future adequately powered RCTs with cognition as a primary endpoint, functional measures, and biomarker outcomes are warranted to clarify lithium's role as a maintenance treatment in psychiatric disorders and its potential neuroprotective effects in neurodegenerative diseases.
Deng R, Shargorodsky A, Teopiz K, Dri CE, Wong S, Le GH, Zheng YJ, McIntyre RS. · CNS spectrums (2026)
In plain English: A definitive larger trial is needed to determine the efficacy of lithium in this cohort.
Rice SM, Nelson B, Amminger GP, Francey SM, Phillips LJ, Simmons MB, Ross M, Yuen HP, Yung AR, O'Gorman K, McGorry PD, Wood SJ, Berger GE. · Early intervention in psychiatry (2024)