1Meta-Analysis2014
Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E · Diabetes Res Clin Pract (2014)
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147 peer-reviewed studies
What the evidence says
Most Lixisenatide studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2010–2026 with a typical study size of 634 participants.
Based on 147 studies · 49 meta-analyses · 84 RCTs · 679 total participants
Confidence
High confidenceBy outcome
39 studies in the last 5 years · Latest meta-analysis: 2026
Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E · Diabetes Res Clin Pract (2014)
Broglio F, Mannucci E, Napoli R, Nicolucci A, Purrello F, Nikonova E · Diabetes Obes Metab (2017)
Messak M, Abdelmageed A, Senbel AA, Khattab YA, Mandour Y, Shaker O · Naunyn Schmiedebergs Arch Pharmacol (2025)
Qin J, Song L · BMC Endocr Disord (2022)
Banerjee M, Pal R, Mukhopadhyay S, Nair K · J Clin Endocrinol Metab (2023)
Hanefeld M, Arteaga JM, Leiter LA, Marchesini G, Nikonova E, Shestakova M · Diabetes Obes Metab (2017)
Bagepally BS, Chaikledkaew U, Gurav YK, Anothaisintawee T, Youngkong S, Chaiyakunapruk N · BMJ Open Diabetes Res Care (2020)
Monami M, Nreu B, Scatena A, Giannini S, Andreozzi F, Sesti G · J Endocrinol Invest (2017)
Li Z, Zhang Y, Quan X, Yang Z, Zeng X, Ji L · PLoS One (2016)
Monami M, Dicembrini I, Marchionni N, Rotella CM, Mannucci E · Exp Diabetes Res (2012)
Chen J, Zhang Q, Wu Q, Zhang X, Xiang Z, Zhu S · J Diabetes (2025)
Ahrén B, Gautier JF, Berria R, Stager W, Aronson R, Bailey CJ · Diabetes Obes Metab (2014)
Visolyi GÁ, Domján BA, Svébis MM, Péterfi A, Lovász BD, Mészáros S · Can J Diabetes (2023)
Xie Z, Hu J, Gu H, Li M, Chen J · Front Endocrinol (Lausanne) (2023)
Htike ZZ, Zaccardi F, Papamargaritis D, Webb DR, Khunti K, Davies MJ · Diabetes Obes Metab (2017)
Hanefeld M, Berria R, Lin J, Aronson R, Darmon P, Evans M · Adv Ther (2014)
Li ZX, Wu SS, Yang ZR, Zhan SY, Sun F · Beijing Da Xue Xue Bao Yi Xue Ban (2016)
Dicembrini I, Nreu B, Scatena A, Andreozzi F, Sesti G, Mannucci E · Acta Diabetol (2017)
Badran AS, Gbreel MI · Neurol Sci (2025)
Alfayez OM, Almohammed OA, Alkhezi OS, Almutairi AR, Al Yami MS · Cardiovasc Diabetol (2020)