1Meta-Analysis2002
Elmfeldt D, Olofsson B, Meredith P · Blood Press (2002)
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611 peer-reviewed studies
What the evidence says
Most Losartan studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1995–2026 with a typical study size of 90 participants.
Based on 609 studies · 18 meta-analyses · 582 RCTs · 876 total participants
Confidence
High confidenceBy outcome
Only 27 studies in the last 5 years · Latest meta-analysis: 2026
Elmfeldt D, Olofsson B, Meredith P · Blood Press (2002)
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Dickstein K · Clin Ther (2001)
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Zhenfeng Zheng, Huilan Shi, Junya Jia, Dong Li, Shan Lin · J Renin Angiotensin Aldosterone Syst (2011)
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Goldberg AI, Dunlay MC, Sweet CS · J Hypertens Suppl (1995)
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Gao L, Chen L, Fan L, Gao D, Liang Z, Wang R · Int J Cardiol (2016)
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Lawrence Gould A, Unniachan S, Wu D · Int J Clin Pract (2014)
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Grosso AM, Bodalia PN, Macallister RJ, Hingorani AD, Moon JC, Scott MA · Int J Clin Pract (2011)
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Li L, Yamani N, Al-Naimat S, Khurshid A, Usman MS · Eur J Prev Cardiol (2020)
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Kang YN, Chi SC, Wu MH, Chiu HH · J Formos Med Assoc (2020)
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Smith DH, Cramer MJ, Neutel JM, Hettiarachchi R, Koval S · Blood Press Monit (2003)
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Meredith PA, Murray LS, McInnes GT · J Hum Hypertens (2010)
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Sharma D, Buyse M, Pitt B, Rucinska EJ · Am J Cardiol (2000)
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He YM, Feng L, Huo DM, Yang ZH, Liao YH · Nephrology (Carlton) (2013)
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Conlin PR, Spence JD, Williams B, Ribeiro AB, Saito I, Benedict C · Am J Hypertens (2000)
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Takagi H, Niwa M, Mizuno Y, Goto SN, Umemoto T · Hypertens Res (2013)
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Fan Y, Wei F, Lang Y, Wang S · J Hypertens (2015)
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Xu X, Naeem A, Emmett A, Siedlinski M, Chinoy H, Guzik TJ · Hypertens Res (2026)
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Xi GL, Cheng JW, Lu GC · Am J Hypertens (2008)
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Yamaura K, Nelson AL, Nishimura H, Rutledge JC, Ravuri SK, Bahney C · Osteoarthritis Cartilage (2023)
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In plain English: However, further powered studies should continue to explore precision medicine analytics and their potential to help identify more effective and personalized interventions.
Tharwani SD, Lynch DH, Boccaccio DE, Spangler H, Gao D, Nelson AE, Zeng D, Batchek D, Batsis JA. · The journals of gerontology. Series A, Biological sciences and medical sciences (2026)