1Meta-Analysis2026
Byambasuren O, Atkins T, Baptista S, Glasziou P, Chakraborty S · BMJ Open (2026)
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76 peer-reviewed studies
What the evidence says
Low-Dose Naltrexone (LDN) doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1989–2026 with a typical study size of 17 participants.
Based on 76 studies · 6 meta-analyses · 36 RCTs · 27 total participants
Confidence
High confidenceBy outcome
39 studies in the last 5 years · Latest meta-analysis: 2026
Byambasuren O, Atkins T, Baptista S, Glasziou P, Chakraborty S · BMJ Open (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Bolton M, Hodkinson A, Boda S, Mould A, Panagioti M, Rhodes S · BMC Med (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Parker CE, Nguyen TM, Segal D, MacDonald JK, Chande N · Cochrane Database Syst Rev (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lobmaier P, Kornør H, Kunøe N, Bjørndal A · Cochrane Database Syst Rev (2008)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Hegde NC, Mishra A, V D, Maiti R, Hota D, Srinivasan A · Curr Pain Headache Rep (2025)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ologunowa A, Otoo MN, Caffrey AR, Buchanan A, Eze UJ, Vyas A · J Pain Palliat Care Pharmacother (2025)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Kim PS, Fishman MA · Curr Pain Headache Rep (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Soin A, Soin Y, Dann T, Buenaventura R, Ferguson K, Atluri S · Pain Physician (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Liubchenko K, Kordbacheh K, Khajehdehi N, Visnjevac T, Ma F, Khan JS · Adv Ther (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: This study did not show that treatment with low-dose naltrexone was superior to placebo in relieving pain.
Due Bruun K et al. · The Lancet. Rheumatology (2024)
Ekelem C, Juhasz M, Khera P, Mesinkovska NA · JAMA Dermatol (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mitchell JE, Christenson G, Jennings J, Huber M, Thomas B, Pomeroy C · J Clin Psychopharmacol (1989)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Radi R, Huang H, Rivera J, Lyon C, DeSanto K · J Fam Pract (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Grant JE, Kim SW, Hartman BK · J Clin Psychiatry (2008)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Bruun-Plesner K, Blichfeldt-Eckhardt MR, Vaegter HB, Lauridsen JT, Amris K, Toft P · Pain Med (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Merckelbach H, Arntz A, de Jong P, Schouten E · Behav Res Ther (1993)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Bouvard MP, Leboyer M, Launay JM, Recasens C, Plumet MH, Waller-Perotte D · Psychiatry Res (1995)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Sharafaddinzadeh N, Moghtaderi A, Kashipazha D, Majdinasab N, Shalbafan B · Mult Scler (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lajevardi V, Salarvand F, Ghiasi M, Nasimi M, Taraz M · J Dermatolog Treat (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Tompkins DA, Lanier RK, Harrison JA, Strain EC, Bigelow GE · Psychopharmacology (Berl) (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.