Luteolin
Crosses the blood-brain barrier to reduce neuroinflammation and inhibits mast cell activation — useful for allergies and brain health.
Luteolin is a flavonoid found in celery, peppers, parsley, and chamomile. It's one of the most potent natural anti-inflammatory compounds, particularly notable for its ability to cross the blood-brain barrier and reduce neuroinflammation. It inhibits mast cell activation, making it useful for allergies and histamine-related conditions. Research also suggests neuroprotective effects and potential benefits for autism spectrum disorders.
Potent inhibitor of inflammatory pathways
Prevents histamine release
Crosses BBB to protect brain cells
How Luteolin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
100-400mg daily
Loading: Not established
Take with food
| Form | Type |
|---|---|
| 💊Luteolin extract or Luteolin-quercetin complex | Recommended |
| 💊Luteolin with palmitoylethanolamide (PEA) | Alternative |
| 💊Chamomile extract (contains luteolin) | Alternative |
Pure luteolin has limited bioavailability. Lipid-based or complexed forms may absorb better.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Better absorbed with fat. Often combined with quercetin or rutin for enhanced effects.
Lower inflammatory markers systemically
Reduced allergic symptoms and histamine reactions
Neuroprotective and cognitive support
May help reduce symptoms; start low
Natural antihistamine properties
May inhibit CYP3A4 enzyme
Tip: Take with food
Top studies from 40+ peer-reviewed papers
Gonfa YH et al. • Zeitschrift fur Naturforschung. C, Journal of biosciences (2025)
“The primary focus of this systematic review is to analyze the current state of the literature regarding treating liver ailments using extracts from medicinal plants, examining their phytochemical composition, and addressing associated safety considerations.”
Gorenshtein A et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
“This systematic-review examined the effects of Luteolin.”
Wu X et al. • Medicine (2024)
“These results provided scientific basis for the clinical use of Danhong injection for the treatment of IPF, and provided a new direction to explore the potential mechanism of action of Danhong injection.”
Weng J et al. • Annals of medicine (2023)
“The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG.”
Qu P et al. • Medicine (2023)
“GSZD could be a satisfactory complementary and alternative therapy for treating gouty arthritis.”
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