We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more
Luteolin
Crosses the blood-brain barrier to reduce neuroinflammation and inhibits mast cell activation — useful for allergies and brain health.
What the evidence says
Luteolin appears to help in 4 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2013–2026 with a typical study size of 100 participants.
Based on 34 studies · 3 meta-analyses · 11 RCTs · 3,404 total participants
Confidence
HighWhat the studies found
By outcome
Luteolin has an evidence score of 8.5/10 — very strong evidence based on 34 indexed studies, including 7 meta-analyses. Crosses the blood-brain barrier to reduce neuroinflammation and inhibits mast cell activation — useful for allergies and brain health.
The commonly studied dose of Luteolin is 100-400mg daily. Research points to an estimated optimal dose around 400mg, with a minimum effective dose near 100mg. Individual response varies — start low and adjust.
The best time to take Luteolin is with meals. Take it with food. Luteolin is a flavone with potent anti-inflammatory, antioxidant, and neuroprotective properties.
Phosphatidylserine
Mostly mechanism / observationalKey brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.
Nicotinamide Riboside
Mostly mechanism / observationalA vitamin B3 precursor that efficiently raises cellular NAD+ levels, supporting energy metabolism, mitochondrial function, and healthy aging.
Last reviewed May 2026 · evidence from 40 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Luteolin is a flavonoid found in celery, peppers, parsley, and chamomile. It's one of the most potent natural anti-inflammatory compounds, particularly notable for its ability to cross the blood-brain barrier and reduce neuroinflammation. It inhibits mast cell activation, making it useful for allergies and histamine-related conditions. Research also suggests neuroprotective effects and potential benefits for autism spectrum disorders.
Potent inhibitor of inflammatory pathways
Prevents histamine release
Crosses BBB to protect brain cells
How Luteolin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
100-400mg daily
Loading: Not established
Take with food
| Form | Type |
|---|---|
| 💊Luteolin extract or Luteolin-quercetin complex | Recommended |
| 💊Luteolin with palmitoylethanolamide (PEA) | Alternative |
| 💊Chamomile extract (contains luteolin) | Alternative |
Pure luteolin has limited bioavailability. Lipid-based or complexed forms may absorb better.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Better absorbed with fat. Often combined with quercetin or rutin for enhanced effects.
Evidence limited to systematic reviews and animal studies. Low bioavailability of standard luteolin forms significantly limits effectiveness. Human RCT data lacking for direct neuroprotective effects.
Lower inflammatory markers systemically
Reduced allergic symptoms and histamine reactions
Neuroprotective and cognitive support
May help reduce symptoms; start low
Natural antihistamine properties
May inhibit CYP3A4 enzyme
Tip: Take with food
Luteolin is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset. Use caution if any of these apply to you: Known allergy or hypersensitivity to Luteolin or related compounds.
Omega-3
Probably helpsEssential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
Tap node to isolate • Pinch to zoom • Tap edge for research