Mgb7.5

Magnolia Bark Research

18 peer-reviewed studies · Evidence score: 7.5/10

The Cardioprotective Effect of Magnolia officinalis and Its Major Bioactive Chemical Constituents

Olas B • International journal of molecular sciences (2025)

There are also no recommendations regarding their effective or safe doses for prophylaxis and the treatment of CVDs.

In addition, there is no clinical evidence for the absorption and bioavailability of M. officinalis extracts and their main bioactive compounds in humans.
Moreover, there are no studies simultaneously comparing the activity of magnolol and honokiol.
Therefore, there is a need for such studies.

Systematic Review

DOI

Depression and Its Phytopharmacotherapy-A Narrative Review

Dobrek L et al. • International journal of molecular sciences (2023)

It provides the mechanisms of action revealed in experimental studies of active ingredients isolated from herbal antidepressants and presents the results of selected clinical studies confirming their antidepressant effectiveness.

Moreover, it is noteworthy that the anti-inflammatory effect is also important to the antidepressant activity of the plants mentioned above in light of the hypothesis that immunological disorders of the CNS are a significant pathogenetic factor of depression.
This narrative review results from a traditional, non-systematic literature review.
It briefly discusses the pathophysiology, symptomatology and treatment of depression, with a particular focus on the role of phytopharmacology in its treatment.

Systematic Review

DOI

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities-A Review

Szałabska-Rąpała K et al. • International journal of molecular sciences (2021)

After careful analysis of many scientific articles, it can be concluded that this lignan is a promising agent supporting the conventional therapies with antidiabetic drugs in order to manage diabetes and diabetes-related diseases.

Magnolol, a polyphenolic compound found in magnolia bark, is known for its health-promoting activities and multidirectional beneficial effects on the body.
Accordingly, the goal of this review is to systematize the available scientific literature on its beneficial effects on type 2 diabetes and its complications.
Taking the above into consideration, the article collects data on the favorable effects of magnolol on parameters related to glycemia, lipid metabolism, or oxidative stress in the course of diabetes.

Systematic Review

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Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre M et al. • Journal of Zhejiang University. Science. B (2017)

The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects.
However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published.
In vitro and in vivo toxicity studies have also been published and indicate some intriguing features.

Systematic Review

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Extracts of Magnolia Species-Induced Prevention of Diabetic Complications: A Brief Review

Zhao X et al. • International journal of molecular sciences (2016)

The aim of this review is to present a systematic overview of bioactive constituents in Magnolia bark that induce the prevention of obesity, hyperglycemia, hyperlipidemia, and diabetic complications, including cardiovascular, liver, and kidney.

Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases.
Several studies have established the anti-inflammatory and oxidative roles of bioactive constituents in Magnolia bark, which has been widely used in the traditional herbal medicines in Chinese society.
These findings have attracted various scientists to investigate the effect of bioactive constituents in Magnolia bark on diabetic complications.

Systematic Review

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Safety and Toxicology of Magnolol and Honokiol

Sarrica A et al. • Planta medica (2018)

In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe.Georg Thieme Verlag KG Stuttgart · New York.

Similar to other dietary polyphenols, magnolol and honokiol are subject to glucuronidation, and despite a relatively quick clearance, an interaction with pharmaceutical active principles or other herbal constituents cannot be excluded.
However, intervention trials employing concentrated MBE for up to 1 y did not report adverse effects.
In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe.Georg Thieme Verlag KG Stuttgart · New York.

Systematic Review

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The impact of chewing gum on halitosis parameters: a systematic review

Muniz FW et al. • Journal of breath research (2017)

However, the low number of included studies and the high heterogeneity among the selected studies may limit the clinical applications of these findings.

Chewing gum containing probiotic bacterium was shown to significantly reduce the organoleptic scores.
Chewing gums containing zinc acetate and magnolia bark extract as well as allylisothiocyanate (AITC) with zinc lactate significantly reduced the levels of VSC in comparison to a placebo chewing gum.
Furthermore, a sodium bicarbonate-containing chewing gum significantly reduced the VSC levels in comparison to rinsing with water.

Systematic Review

DOI

Is there a potential of misuse for Magnolia officinalis compounds/metabolites?

Schifano F et al. • Human psychopharmacology (2017)

To the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse.

To the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse.
Further research warranted to confirm findings

Systematic Review

DOI

Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review

Thomas AJ et al. • Maturitas (2014)

Isoflavone trials yielded significant reductions on hot flashes and co-occurring symptoms during the menopausal transition and postmenopause, but studies require replication with larger sample sizes and attention to measurement of outcomes.

In five trials of soy isoflavone preparations, two (6g soy germ extract and 25 g soy protein in soy nuts) significantly decreased hot flashes, but no other symptoms.
The only trial in this systematic review that significantly reduced cognitive symptoms was red clover (80 mg).
Equol supplements of 30 mg/day for non-Equol producing women significantly reduced mood symptoms in one trial.

Systematic Review

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Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause

Agosta C et al. • Minerva ginecologica (2011)

Isoflavones are effective in improving the classical menopause symptoms.

In 91 gynecological centers, 634 women were treated (300 with E and 334 with ES), mean age 53.1 years and Body Mass Index (BMI) 25.2 kg/m2; 28% were past hormone replacement therapy HRT users and 3.3% had had a previous breast cancer.
Both treatments significantly reduced versus baseline the symptoms tested at 0, 4, 8 and 12 weeks.
Woman's well-being and physician's final judgment were positive in >70% in both groups.

RCTn=634

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Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial

Campus G et al. • Caries research (2011)

This rct examined the effects of Magnolia Bark.

Magnolia gum significantly reduced plaque acidogenicity, MS salivary concentration and gingival bleeding compared to xylitol and control gums.
Subjects from the magnolia and xylitol groups showed both MS concentration (p = 0.01 and 0.06, respectively) and AUC(5.7) (p = 0.01 and 0.04, respectively) to be significantly lower compared to baseline.
Thirty-day use of a chewing gum containing MBE showed beneficial effects on oral health, including reduction of salivary MS, plaque acidogenicity and bleeding on probing.

RCTn=120

DOI

The effect of zinc lactate and magnolia bark extract added tablets on volatile sulfur-containing compounds in the oral cavity

Porciani PF et al. • The Journal of clinical dentistry (2014)

Tablets containing zinc lactate and magnolia bark extract can statistically significantly reduce the oral VSC levels for over two hours and were statistically significantly more effective than a control tablet.

The comparisons between the two groups after baseline adjustment showed a statistically significant difference in reductions of VSC between the test and the control tablets at the end of the sucking period (p < 0.01), after one hour (p < 0.001), and after two hours (p < 0.05).
Tablets containing zinc lactate and magnolia bark extract can statistically significantly reduce the oral VSC levels for over two hours and were statistically significantly more effective than a control tablet.
Further research warranted to confirm findings

RCTn=52

DOI

Magnolia and Phellodendron for stress-related symptoms

Talbott SM et al. • Journal of the International Society of Sports Nutrition (2013)

Relora reduced cortisol and improved mood in stressed adults.

Reduced cortisol levels
Improved mood and stress
Reduced stress-eating

RCTn=40

DOI

Self-perceived mouthfeel and physico-chemical surface effects after chewing gums containing sorbitol and Magnolia bark extract

Wessel SW et al. • European journal of oral sciences (2017)

Accordingly, adsorption of sorbitol, rather than the presence of Magnolia bark extract or increased salivation, is responsible for improved self-perceived mouthfeel.

Simultaneously, saliva samples were collected, placed on glass slides, and the compositions of the adsorbed film were measured using X-ray photoelectron spectroscopy.
Chewing of gum, regardless of whether or not it contained Magnolia bark extract, improved self-perceived mouthfeel up to 60 min, concurrent with a more hydrophilic tooth surface and an increased amount of O1s electrons bound at 532.6 eV in salivary films.
Chewing of Parafilm affected neither tooth-surface hydrophobicity nor salivary-film composition.

RCT

DOI

[Application of dannang recipe no. 2 in the perioperative stage of laparoscopic cholecystectomy]

Xu L et al. • Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (2008)

Application of DNR2 in perioperative stage of laparoscopic cholecystectomy can effectively promote the recovery of postoperative gastrointestinal motility and suppress the occurrence of acute inflammation.

Application of DNR2 in perioperative stage of laparoscopic cholecystectomy can effectively promote the recovery of postoperative gastrointestinal motility and suppress the occurrence of acute inflammation.
Further research warranted to confirm findings

RCTn=360

Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause

Mucci M et al. • Minerva ginecologica (2006)

The controlled study showed the efficacy of Magnolia extract and magnesium on psycho-affective and sleep disturbances in menopause, in addition to the effects of isoflavones on vasomotor symptoms.

Flushing, nocturnal sweating, palpitations, insomnia, asthenia, anxiety, mood depression, irritability, vaginal dryness, dyspareunia, and libido loss, significantly decreased in severity and frequency during ES versus Ca+D treatment even since the fourth week.
Woman wellbeing (good/very good 66.7% vs 20%) judgement on efficacy (72.7% vs 17.1%) and acceptability (93.9% vs 31.4%) were significantly better for ES.
The controlled study showed the efficacy of Magnolia extract and magnesium on psycho-affective and sleep disturbances in menopause, in addition to the effects of isoflavones on vasomotor symptoms.

RCT

Honokiol: A Review of Its Pharmacological Potential and Therapeutic Insights

Rauf A et al. • Phytomedicine (2021)

Honokiol demonstrates significant anxiolytic, neuroprotective, anti-inflammatory, and anticancer properties through multi-target mechanisms.

Honokiol modulates GABA-A receptors contributing to anxiolytic effects without sedation
Significant anti-inflammatory activity through NF-kB pathway inhibition
Neuroprotective effects demonstrated in multiple neurodegenerative disease models

Review

DOI

Effect of honokiol on activity of GAD(65) and GAD(67) in the cortex and hippocampus of mice

Ku TH et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2011)

In addition, the activity of hippocampal GAD(65) of honokiol treated mice was significantly increased than that of the vehicle or diazepam treated groups.

In addition, the activity of hippocampal GAD(65) of honokiol treated mice was significantly increased than that of the vehicle or diazepam treated groups.
Mice treated with 7 daily injection of honokiol (1mg/kg, p.o.) caused anxiolytic action which was similar to that was induced by 7 daily injection of diazepam (2mg/kg, p.o.) in the elevated plus-maze test.
These data suggest that honokiol causes diazepam-like anxiolytic action, which may be mediated by altering the synthesis of GABA in the brain of mice.

Animal

DOI

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