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Mangosteen (Garcinia mangostana)
A tropical fruit whose purple rind (pericarp) is rich in xanthones such as alpha-mangostin, marketed for antioxidant and anti-inflammatory effects. The evidence is mostly preclinical; the few human trials are small and largely local (oral/periodontal) or pilot-grade.
What the evidence says
Most Mangosteen studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2008–2017 with a typical study size of 50 participants.
Based on 4 studies · 2 RCTs · 90 total participants
Confidence
LowBy outcome
Mangosteen has an evidence score of 2.5/10 — emerging evidence based on 4 indexed studies. A tropical fruit whose purple rind (pericarp) is rich in xanthones such as alpha-mangostin, marketed for antioxidant and anti-inflammatory effects. The evidence is mostly preclinical; the few human trials are small and largely local (oral/periodontal) or pilot-grade. Representative study: PMID 28321995.
The commonly studied dose of Mangosteen is No established efficacy dose. Pilot trials used 9-18 oz/day of a proprietary juice blend; pericarp capsule products commonly provide 500-1000mg.. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
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Last reviewed June 2026 · evidence from 4 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Mangosteen (Garcinia mangostana) is a Southeast Asian fruit whose inedible purple rind contains xanthones — notably alpha- and gamma-mangostin — with well-documented antioxidant and anti-inflammatory activity in cell and animal models. Xanthones can attenuate inflammatory signaling (MAPK, AP-1, NF-κB) in cultured human macrophages and adipocytes, which underpins the marketing. But human evidence is sparse and indirect: the strongest systemic trial is a small obese-subjects pilot in which a proprietary juice blend lowered C-reactive protein only at the highest dose, with most other markers unchanged. Other randomized human data come from dental studies using mangosteen pericarp gel or mouthwash for gingivitis and periodontitis — local applications, not systemic supplementation. A schizophrenia adjunct trial exists only as a published protocol. As an oral antioxidant/anti-inflammatory supplement, mangosteen remains an emerging, largely unproven option, and commercial 'mangosteen juice' is often a sugar-heavy proprietary blend.
Alpha- and gamma-mangostin attenuate LPS-induced inflammatory gene expression and MAPK/AP-1/NF-κB activation in cultured human macrophages and adipocytes.
Mangosteen xanthones scavenge reactive oxygen species in laboratory assays, the basis for its antioxidant marketing.
How Mangosteen works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
No established efficacy dose. Pilot trials used 9-18 oz/day of a proprietary juice blend; pericarp capsule products commonly provide 500-1000mg.
Take with food
| Form | Type |
|---|---|
| 💊Pericarp extract capsule | Recommended |
| 💊Mangosteen juice blend | Alternative |
| 🧴Pericarp gel (topical/dental) | Alternative |
For oral malodor/periodontal support, topical pericarp gel has the best human data; systemic supplementation is unproven.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: With food; no specific timing benefit established.
Dose-response data unavailable. The current published research for Mangosteen does not provide sufficient dose-specific outcome data to generate reliable dose-response curves.
Refer to the Dosage & Timing section above for recommended dose ranges based on available evidence.
A proprietary juice blend lowered C-reactive protein vs placebo, but only at the highest tested dose in a small pilot.
Pericarp gel/mouthwash improved gingivitis and periodontitis markers as an adjunct to dental cleaning.
No trial demonstrates systemic disease, immune, or longevity benefits from oral supplementation.
Not adequately studied as a supplement — avoid concentrated extracts.
Use caution with high-dose xanthone products.
Xanthones may have mild antiplatelet activity in laboratory studies; clinical relevance is unproven but warrants caution at high doses.
Limited theoretical concern; no well-documented clinical interaction.
Tip: Take with food; reduce dose
Tip: Avoid chronic high-dose juice consumption
Both are plant polyphenols/flavonoids with anti-inflammatory activity in preclinical models.
Layered anti-inflammatory phytochemical intake (theoretical only).
Both are antioxidants commonly paired in superfruit formulations.
Broader antioxidant exposure; no proven additive clinical benefit.
The best time to take Mangosteen is with meals. Take it with food. Taken with meals; no trial-validated systemic supplement dose exists.
Mangosteen is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are mild GI upset, lactic acidosis (very rare, reported with prolonged high-dose juice use). Use caution if any of these apply to you: Known allergy to mangosteen; Patients on anticoagulants (theoretical bleeding concern with xanthones — limited data).
Blue-green algae with 60-70% complete protein and unique phycocyanin antioxidant — lowers cholesterol, blood pressure, and blood sugar.
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