Mr7.5

Marshmallow Root Research

12 peer-reviewed studies · Evidence score: 7.5/10

Interplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways

Imtiaz I et al. • Biomolecules (2025)

Thus, the development of anticancer therapeutics continues to benefit from the synergy of traditional knowledge, scientific innovation, and technological advancements.

Curcumin and baicalin show preclinical effectiveness but face bioavailability challenges, which may be overcome by combining them with piperine or using oral extracts to enhance gut microbiome conversion, integrating traditional knowledge with modern strategies for improved outcomes.
Furthermore, herbal extracts from Echinacea, Glycyrrhiza, and Codonopsis, identified in traditional knowledge, are currently in clinical trials.
Notably, curcumin and baicalin also modulate miRNA pathways, highlighting a promising intersection of modern science and traditional medicine.

Systematic Review

DOI

Aromatic plants as cosmeceuticals: benefits and applications for skin health

Olivero-Verbel J et al. • Planta (2024)

This systematic-review examined the effects of Marshmallow Root.

Osbeck (Rutaceae), emphasizing their potential in skincare formulations and their role in promoting health and rejuvenation.
Further research warranted to confirm findings

Systematic Review

DOI

The use of babosa (Aloe vera) in treating burns: a literature review

Zago LR et al. • Brazilian journal of biology = Revista brasleira de biologia (2021)

Even with evidence that suggests the efficacy in the treatment of burns with the use of Aloe Vera extract, further clinical trials with larger sample space on the use of Aloe vera dressings in medium burns are suggested for further conclusions.

Aloe vera had 13.8% cited by individuals in the treatment of acne and 33.6% in the treatment of burns.
Finally, in the article by Zurita and Gallegos (2017), it carried out a descriptive cross-sectional study with 321 people, both sexes between 17-76 years of age, of an inductive nature, exploring the experience of this population and their behavioral attitudes regarding the treatment of dermatoses.
Even with evidence that suggests the efficacy in the treatment of burns with the use of Aloe Vera extract, further clinical trials with larger sample space on the use of Aloe vera dressings in medium burns are suggested for further conclusions.

Systematic Reviewn=50

DOI

Marsh Mallow (Althaea officinalis L.) and Its Potency in the Treatment of Cough

Mahboubi M • Complementary medicine research (2020)

This systematic-review examined the effects of Marshmallow Root.

The results of animal and clinical studies confirmed the efficacy of A. officinalis extracts alone in treatment of dry cough, while combination of A. officinalis with Zataria multiflora, Zingiber officinalis, or Helix hedera increased the efficacy of A. officinalis and improved all kinds of cough.
Different mechanisms are involved in expectorant and antitussive effects of A. officinalis in treatment of cough.
Therefore, A. officinalis in combination with other plant extracts in different forms of drug could be a good choice for cough, sore throat, and other respiratory ailments.

Systematic Review

DOI

Management of acute cough by Zataria multiflora Boiss as an alternative treatment

Mahboubi M • Journal of integrative medicine (2018)

Different mechanisms, such as anti-inflammatory, analgesic, antimicrobial, relaxant and immune-enhancement, may be responsible for the efficacy of Z. multiflora in cough relief.

Different mechanisms, such as anti-inflammatory, analgesic, antimicrobial, relaxant and immune-enhancement, may be responsible for the efficacy of Z. multiflora in cough relief.
Other clinical trials can be performed with Z. multiflora in combination with ivy leaf extract or primrose root extract on patients with cough.

Systematic Review

DOI

Phytotherapeutics: an evaluation of the potential of 1000 plants

Cravotto G et al. • Journal of clinical pharmacy and therapeutics (2010)

The present review provides a baseline on the level of evidence available on many herbal preparations and should be of help to those intending to research further on these topics.

We found that for about 12% of the plants, currently available on the Western market, no substantial studies on their properties had been published, while there was strong evidence that 1 in 200 were toxic or allergenic, so that their use ought to be discouraged or forbidden.
The present review provides a baseline on the level of evidence available on many herbal preparations and should be of help to those intending to research further on these topics.
Further research warranted to confirm findings

Systematic Review

DOI

The efficacy of complementary treatment with marshmallow (Althaea officinalis L.) on vulvovaginal candidiasis: A randomized double-blinded controlled clinical trial

Amini F et al. • Explore (New York, N.Y.) (2023)

It seems that CLOT-M vaginal cream had a significant effect on the VVC symptoms improvement, without any significant side effects.

Moreover, after 7 days of the intervention, patients in the CLOT-M group experienced significant improvement in mean dysuria score compared to those in the control group (P = 0.001).
It seems that CLOT-M vaginal cream had a significant effect on the VVC symptoms improvement, without any significant side effects.
However, larger sample-sized trials are needed for more evidence-based judgment.

RCTn=100

DOI

A randomized, open-label, multicenter, comparative study of therapeutic efficacy, safety and tolerability of BNO 1030 extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark, dandelion herb in the treatment of acute non-bacterial tonsillitis in children aged 6 to 18 years

Popovych V et al. • American journal of otolaryngology (2019)

BNO 1030 (Imupret®) is a safe and effective product for treatment of acute non-bacterial tonsillitis in children aged 6-18 years, assuring therapeutic benefit when prescribed additionally to the standard symptomatic therapy.

BNO 1030 (Imupret®) is a safe and effective product for treatment of acute non-bacterial tonsillitis in children aged 6-18 years, assuring therapeutic benefit when prescribed additionally to the standard symptomatic therapy.
Further research warranted to confirm findings

RCTn=238

DOI

The Effect of Hollyhock (Althaea officinalis L) Leaf Compresses Combined With Warm and Cold Compress on Breast Engorgement in Lactating Women: A Randomized Clinical Trial

Khosravan S et al. • Journal of evidence-based complementary & alternative medicine (2017)

According to the findings, hollyhock leaf compress combined with performing routine interventions for breast engorgement can improve breast engorgement.© The Author(s) 2015.

The data collected were analyzed in SPSS-16 using a generalized estimating equation.
According to the results, a significant difference was observed in the overall breast engorgement severity in the intervention group (P < .001).
According to the findings, hollyhock leaf compress combined with performing routine interventions for breast engorgement can improve breast engorgement.© The Author(s) 2015.

RCTn=40

DOI

Comparison between three different saliva substitutes in patients with hyposalivation

Skrinjar I et al. • Clinical oral investigations (2015)

We recommend the use of all three saliva substitutes for decreasing the intensity of dry mouth symptoms as well as improvement in the quality of life.

We recommend the use of all three saliva substitutes for decreasing the intensity of dry mouth symptoms as well as improvement in the quality of life.
Further research warranted to confirm findings

RCTn=60

DOI

Open trial to assess aspects of safety and efficacy of a combined herbal cough syrup with ivy and thyme

Büechi S et al. • Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine (2005)

Considering the traditional use of ivy leaves, thyme herb, aniseed and marshmallow root in preparations for cough, the reduction in the symptom score as well as the good tolerability the investigated combined herbal cough syrup seems to alleviate cough in consequence of common cold, bronchitis or respiratory tract diseases with formation of mucus.

Doctors and patients assessed efficacy as good or very good in 86% and 90% of the cases, respectively.
Tolerability was assessed as good or very good by 97% of the doctors and patients.
Further research warranted to confirm findings

RCTn=62

DOI

Nursing Procedures for the Prevention and Treatment of Mucositis Induced by Cancer Therapies: Clinical Practice Guideline Based on an Interdisciplinary Consensus Process and a Systematic Literature Search

Steinmann D et al. • Integrative cancer therapies (2021)

The current evidence supports the use of some nursing procedures (f.e. propolis for 2 and 3 grade mucositis) for improving oral mucositis during cancer therapies.

The current evidence supports the use of some nursing procedures (f.e. propolis for 2 and 3 grade mucositis) for improving oral mucositis during cancer therapies.
There is still a need to define general clinical practice guidelines for the supportive treatment of mucositis, as well as for more interdisciplinary research in this area.
Further research warranted to confirm findings

Observationaln=329

DOI

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