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5 peer-reviewed studies
What the evidence says
Most Methylene Blue studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality randomised trials published 2014–2020 with a typical study size of 26 participants.
Based on 5 studies · 2 RCTs · 52 total participants
Confidence
LowBy outcome
Newest study from 2020
Low-dose methylene blue modulated functional connectivity in the human brain and improved memory retrieval.
Rodriguez, Singh, Malloy, Zhou, Barrett, Franklin · Brain imaging and behavior (2017)
A randomized functional-MRI study showed low-dose methylene blue increased brain responses during memory and attention tasks.
Rodriguez, Zhou, Barrett, Altmeyer, Gutierrez, Li · Radiology (2016)
Targeting mitochondrial respiration — including with methylene blue — is a strategy for neuroprotection and cognitive enhancement.
Gonzalez-Lima, Barksdale, Rojas · Biochemical pharmacology (2014)
Methylene blue showed anti-aging potential for human skin longevity in fibroblast models.
Xiong, O'Donovan, Sun, Choi, Ren, Cao · Scientific reports (2017)
Antioxidants including methylene blue affect the replicative lifespan of fibroblasts in vitro.
Sadowska-Bartosz, Bartosz · Oxidative medicine and cellular longevity (2020)