1Meta-Analysis2024
Fernando SM, Tran A, Soliman K, Flynn B, Oommen T, Wenzhe L · Crit Care Explor (2024)
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61 peer-reviewed studies
What the evidence says
Most Methylene Blue studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2001–2026 with a typical study size of 257 participants.
Based on 61 studies · 7 meta-analyses · 45 RCTs · 257 total participants
Confidence
High confidenceBy outcome
16 studies in the last 5 years · Latest meta-analysis: 2026
Fernando SM, Tran A, Soliman K, Flynn B, Oommen T, Wenzhe L · Crit Care Explor (2024)
Alkazemi A, Almoosawy SA, Murad A, Alfares A · J Intensive Care Med (2026)
Deng M, Huang H, Ma YG, Zhou Y, Chen Q, Xie P · J Neurol Surg A Cent Eur Neurosurg (2021)
Huang X, Yan W, Chen Z, Qian Y · BMJ Open (2024)
Guo X, Ding W, Liu L, Yang S · Pain Pract (2019)
Pasin L, Umbrello M, Greco T, Zambon M, Pappalardo F, Crivellari M · Crit Care Resusc (2013)
Zuschlag ZD, Warren MW, K Schultz S · Psychosomatics (2018)
Kwok ES, Howes D · J Intensive Care Med (2006)
Lu G, Nagbanshi M, Goldau N, Mendes Jorge M, Meissner P, Jahn A · BMC Med (2018)
Otero Luna AV, Johnson R, Funaro M, Canarie MF, Pierce RW · Pediatr Crit Care Med (2020)
Arevalo VN, Bullerwell ML · AANA J (2018)
Ng BK, Cameron AJ · Psychosomatics (2010)
Dong C, Zhu J, Ni H, Chen Y, Chen B, Zhang M · Drug Des Devel Ther (2025)
Alda M, McKinnon M, Blagdon R, Garnham J, MacLellan S, O'Donovan C · Br J Psychiatry (2017)
Coulibaly B, Zoungrana A, Mockenhaupt FP, Schirmer RH, Klose C, Mansmann U · PLoS One (2009)
Zoungrana A, Coulibaly B, Sié A, Walter-Sack I, Mockenhaupt FP, Kouyaté B · PLoS One (2008)
Coulibaly B, Pritsch M, Bountogo M, Meissner PE, Nebié E, Klose C · J Infect Dis (2015)
Hamidi-Alamdari D, Hafizi-Lotfabadi S, Bagheri-Moghaddam A, Safari H, Mozdourian M, Javidarabshahi Z · Rev Invest Clin (2021)
Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K · Lancet Infect Dis (2018)
Geurts JW, Kallewaard JW, Kessels A, Willems PC, van Santbrink H, Dirksen C · Trials (2015)