39 peer-reviewed studies · Evidence score: 9/10
Miao R et al. • Phytotherapy research : PTR (2025)
However, further validation of these findings is necessary through extensive clinical studies with larger sample sizes.
Shahsavari K et al. • BMC complementary medicine and therapies (2025)
This meta-analysis examined the effects of Milk Thistle.
Liu H et al. • Phytotherapy research : PTR (2024)
This study may help guide clinicians and lead to further detailed studies.
Li S et al. • Annals of hepatology (2024)
Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients.
Osadnik T et al. • Pharmacological research (2022)
Evidence for bergamot effect was based on relatively small study group and may require further investigations.
Yang K et al. • Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Amini S et al. • Phytotherapy research : PTR (2023)
However, due to the limited number of studies, further high-quality studies are warranted.
Niu H et al. • Pharmacological research (2021)
In management RCTs, the efficacy parameter was usually 50 % decrease or normalisation of liver enzymes, or survival rate in DILI-related ALF patients.
Kalopitas G et al. • Journal of Clinical Gastroenterology (2021)
Silymarin supplementation significantly reduced ALT and AST levels in patients with liver diseases compared to placebo.
Zhong S et al. • Clinical Nutrition ESPEN (2021)
Silymarin significantly improved liver enzyme levels and hepatic steatosis in NAFLD patients.
Mohtashaminia F et al. • Clinical nutrition ESPEN (2022)
We did not find any significant reduction in liver enzymes following BBR-silymarin consumption in adults.
Tao L et al. • Canadian journal of gastroenterology & hepatology (2019)
Prophylactic therapy of silymarin is contributed to a noticeably reduced risk of development of anti-TB DILI four weeks after the initiation.
Fogacci F et al. • Phytotherapy research : PTR (2019)
The present findings suggest that the coadministration of berberine and silymarin is associated with an advantageous improvement in lipid and glucose profile, suggesting the possible use of this nutraceutical combination in order to promote the cardiometabolic health.
Hoffman J et al. • The Cochrane database of systematic reviews (2021)
There was insufficient evidence from meta-analysis to confirm or refute the efficacy of any agent or class of medication for the treatment of TTM in adults, children or adolescents.
Raza A et al. • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2022)
Though oral and topical antioxidants significantly improved mucositis severity scores in HNC patients receiving radiotherapy with/without chemotherapy in individual studies, the quality of the evidence was low due to the small number of studies and unclear/high-risk bias.
Ranneh Y et al. • Nutrients (2024)
Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
Mohammadi S et al. • Phytotherapy research : PTR (2024)
Additional high-quality RCTs with longer durations are required to determine the clinical efficacy of SIL supplementation on renal and oxidative stress markers.
Rambaldi A et al. • The American journal of gastroenterology (2005)
Based on high-quality trials, MT does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases.
Wang Y et al. • Drugs (2024)
The results of the comprehensive analysis suggested hypoglycemic drug therapy as an effective intervention for NAFLD, with or without diabetes mellitus.
Gupta J et al. • Current medicinal chemistry (2024)
In most cases, silymarin/silibinin administration could sensitize the cancer cells to ionizing radiation through an increase of free radical formation, induction of DNA damage, increase of apoptosis, inhibition of angiogenesis and metastasis, etc.