Mo8.5

Molybdenum Research

40 peer-reviewed studies · Evidence score: 8.5/10

Change in Mineral Status After Bariatric Surgery: a Meta-analysis

Cao L et al. • Obesity surgery (2023)

A high deficiency rate of serum iron, zinc, copper, chlorine, phosphorus, and calcium was seen after bariatric surgery.

The most severe mineral deficiency after bariatric surgery was iron (20.1%), followed by zinc (18.3%), copper (14.4%), chlorine (12.2%), phosphorus (7.5%), and calcium (7.4%).
The difference in surgical procedures, study regions, and follow-up time may affect postoperative mineral status; more targeted mineral supplement programs are needed considering these influencing factors.
Further research warranted to confirm findings

Meta-Analysisn=47,432

DOI

A systematic review and meta-analysis of the hyperuricemia risk from certain metals

Gu T et al. • Clinical rheumatology (2022)

The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).

Data were pooled by random-effects models and expressed as pooled odds ratios (OR) and 95% confidence intervals (CIs).
Exposure to molybdenum (pooled OR = 0.804, 0.724, 0.975, 3, 0%) was linked to a decreased risk of HUA, however.
Molybdenum exposure was associated with a decreased prevalence of HUA; however, aluminum, cobalt, copper, iron, magnesium, manganese, mercury, selenium, thallium and zinc are not associated with HUA risk.

Meta-Analysisn=63,283

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Human gingival fibroblast proliferation on materials used for dental implant abutments: a systematic review

Paul S et al. • The International journal of prosthodontics (2021)

Titanium surfaces with directional guidance patterning and zirconia surfaces best supported cell proliferation during the first week of cell culture.

Titanium surfaces with directional guidance patterning and zirconia surfaces best supported cell proliferation during the first week of cell culture.
Lack of standardization in surface definitions (machined or polished), methodology, and reporting prevented analytical comparison and should be imposed in future studies.
Further research warranted to confirm findings

Systematic Reviewn=1,144

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Metal ion concentrations in body fluids after implantation of hip replacements with metal-on-metal bearing--systematic review of clinical and epidemiological studies

Hartmann A et al. • PloS one (2013)

Highest metal ion concentrations were observed after treatment with stemmed large-head MoM-implants and hip resurfacing arthroplasty.

Systematic review examining Molybdenum efficacy
Further research warranted to confirm findings

Systematic Reviewn=957

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Lead, cadmium, and other trace elements in the liver of golden eagles and white-tailed eagles: recent data from Poland and a systematic review of previous studies

Durkalec MM et al. • Environmental science and pollution research international (2023)

This systematic-review examined the effects of Molybdenum.

The hepatic Pb found in almost half of all the tested individuals suggests environmental exposure to this toxic element.
One of the tested white-tailed eagles had hepatic Pb above the threshold of sublethal poisoning.
Although our results seem optimistic, as previous Polish studies showed a higher prevalence of birds with hepatic Pb exceeding the toxicity threshold, they indicate that exposure to this toxic metal could still pose an additional threat to the health of Polish eagles.

Systematic Review

DOI

A Systematic Literature Review on the Association Between Toxic and Essential Trace Elements and the Risk of Orofacial Clefts in Infants

Shiani A et al. • Biological trace element research (2024)

The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Based on the findings, it is acceptable to infer that maternal exposure to toxic elements, whether through environmental contaminants or dietary sources, was associated with an elevated risk of OFCs.
Furthermore, the study revealed that ETEs exhibited a potential protective role in reducing the incidence of OFCs.
This observation highlights the importance of reducing exposure to toxic elements during pregnancy and suggests that optimizing maternal intake of ETEs could be an effective preventive strategy.

Systematic Review

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Consensus guidelines for the diagnosis and management of isolated sulfite oxidase deficiency and molybdenum cofactor deficiencies

Schwahn BC et al. • Journal of inherited metabolic disease (2024)

Journal of Inherited Metabolic Disease

This prompted the formulation of these clinical guidelines to facilitate diagnosis and support the management of patients.
The guidelines were developed by experts in diagnosis and treatment of sulfite intoxication disorders.
It reflects expert consensus opinion and evidence from a systematic literature search.

Systematic Review

DOI

ESPEN micronutrient guideline

Berger MM et al. • Clinical nutrition (Edinburgh, Scotland) (2022)

This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases.

The recommendations underwent a consensus process, which resulted in a percentage of agreement (%): strong consensus required of >90% of votes.
This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases.
In particular, it offers practical advice on MN provision and monitoring during nutritional support.

Meta-Analysis

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Interaction between selenium and essential micronutrient elements in plants: A systematic review

Gui JY et al. • The Science of the total environment (2022)

The regulatory mechanisms of Se on these micronutrients are also analyzed.

The regulatory mechanisms of Se on these micronutrients are also analyzed.
Based on the current understanding of the interaction between Se and these essential elements, future directions for research are suggested.

Systematic Review

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Evaluation of nutrients in bread: a systematic review

Aghalari Z et al. • Journal of health, population, and nutrition (2022)

The results of this study showed that the concentration of nutrients in most articles was undesirable.

The results of this study showed that the concentration of nutrients in most articles was undesirable.
It is suggested that optimal methods of enrichment of breads and flours be done with interdisciplinary cooperation between food hygiene, environmental health, nutrition, farmers and bakers.
It is recommended that food hygiene and environmental health researchers investigate other nutrients (including phosphorus, selenium, manganese, boron and molybdenum) in breads and other staple foods used by people to constructive and practical measures to increase public health.

Systematic Review

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Assessment of metal ion accumulation in oral mucosa cells of patients with fixed orthodontic treatment and cellular DNA damage: a systematic review

Piñeda-Zayas A et al. • Critical reviews in toxicology (2021)

However, more long-term studies are needed to evaluate chronic exposure to metals and DNA damage, as well as cellular capacity to recover DNA integrity.

Cytotoxicity was evaluated (4/7) using the trypan blue dye test.
Accumulations of nickel (7/7), chromium (5/7), and other metals (zinc, cobalt, iron, manganese, molybdenum, titanium) were also quantified.
The results allowed us to conclude that release of metal ions and acute cell and DNA damage in oral mucosa cells takes place in the early stages of treatment.

Systematic Review

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Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review

Michelsen-Correa S et al. • International journal of environmental research and public health (2021)

Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.

What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals.
The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes.
A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures.

Meta-Analysis

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Neonatal seizures as onset of Inborn Errors of Metabolism (IEMs): from diagnosis to treatment. A systematic review

Falsaperla R et al. • Metabolic brain disease (2021)

This systematic-review examined the effects of Molybdenum.

Herein, we report a systematic review on those IEMs that lead to NS and epilepsy in the neonatal period, studying only those IEMs not included in the ENS with tandem mass, suggesting clinical, biochemical features, and diagnostic work-up.
Remarkably, we have observed a worse neurological outcome in infants undergoing only a treatment with common AED for their seizures, in comparison to those primarily treated with specific anti-convulsant treatment for the underlying metabolic disease (e.g.Ketogenic Diet, B6 vitamin).
For this reason, we underline the importance of an early diagnosis in order to promptly intervene with a targeted treatment without waiting for drug resistance to arise.

Systematic Review

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A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications

Takooree H et al. • Critical reviews in food science and nutrition (2019)

As a conclusive remark, P. nigrum should not only be regarded as "King of spices" but can also be considered as part of the kingdom of medicinal agents, comprising a panoply of bioactive compounds with potential nutraceutical and pharmaceutical applications.

The major bioactive compound identified in P. nigrum is piperine although other compounds are also present including piperic acid, piperlonguminine, pellitorine, piperolein B, piperamide, piperettine, and (-)-kusunokinin, which also showed biological potency.
Most pharmacological studies were conducted in vitro (n = 60) while only 21 in vivo and 1 clinical trial were performed.
Hence, more in vivo experiments using a pharmacokinetic and pharmacokinetic approach would be beneficial.

Systematic Review

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Beyond the Mind-Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review

Baj J et al. • International journal of molecular sciences (2020)

However, it can be assumed that altered concentrations of those elements are crucial regarding the onset and exaggeration of either psychotic or negative symptoms or cognitive dysfunctions.

This review includes the analysis of serum levels of the following trace elements: iron, nickel, molybdenum, phosphorus, lead, chromium, antimony, uranium, magnesium, aluminum, zinc, copper, selenium, calcium, and manganese.
Currently, there is no consistency regarding serum trace element levels in schizophrenic patients.
Thus, it cannot be considered as a reliable prognostic or diagnostic marker of schizophrenia.

Systematic Review

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Environmental etiology of gastric cancer in Iran: a systematic review focusing on drinking water, soil, food, radiation, and geographical conditions

Ghaffari HR et al. • Environmental science and pollution research international (2019)

Given the risk factors identified, strategies to prevent GC would be educating people to choose a healthy diet and to cook and store food properly, providing access to safe drinking water, taking into account topographical and geographical conditions in choosing a right location to build residential areas, and regulating the use of radiation-emitting devices.

Twenty-six articles were found to meet the inclusion criteria after title, abstract, and full text review.
Fresh fruits and vegetable, fresh fish, and honey consumption were recognized as protective agents.
Further research warranted to confirm findings

Systematic Review

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Parenteral trace element provision: recent clinical research and practical conclusions

Stehle P et al. • European journal of clinical nutrition (2016)

To avoid trace element deprivation or imbalances, physiological doses are recommended.

Important physiological functions in human metabolism are known for nine trace elements: selenium, zinc, copper, manganese, chromium, iron, molybdenum, iodine and fluoride.
Lack of, or an insufficient supply of, these trace elements in nutrition therapy over a prolonged period is associated with trace element deprivation, which may lead to a deterioration of existing clinical symptoms and/or the development of characteristic malnutrition syndromes.
Therefore, all parenteral nutrition prescriptions should include a daily dose of trace elements.

Systematic Review

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Australasian Society for Parenteral and Enteral Nutrition guidelines for supplementation of trace elements during parenteral nutrition

Osland EJ et al. • Asia Pacific journal of clinical nutrition (2014)

Trace elements are essential and should be provided daily to patients receiving parenteral nutrition.

Trace elements are essential and should be provided daily to patients receiving parenteral nutrition.
Monitoring is generally only required in longer term parenteral nutrition, however should be determined on an individual basis.
Industry is encouraged to modify existing multi-trace element solutions available in Australia and New Zealand to reflect changes in the literature outlined in these guidelines.

Systematic Review

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Prosthesis design of animal models of periprosthetic joint infection following total knee arthroplasty: A systematic review

Jie K et al. • PloS one (2019)

A highly representative design of the animal prosthesis of PJI should meet the following criteria: the surface of the prosthesis is smooth with the formation of biofilm, composed of titanium-6Al-4V or cobalt-chromium-molybdenum alloy; prosthesis can bear weight and is highly stable; and it can connect the joint cavity and medullary cavity simultaneously.

To reach a more reliable conclusion, further experiments and improvements are required.
Further research warranted to confirm findings

Systematic Reviewn=12

DOI

Trace elements in hemodialysis patients: a systematic review and meta-analysis

Tonelli M et al. • BMC medicine (2009)

Average blood levels of biologically important trace elements were substantially different in hemodialysis patients, compared with healthy controls.

Average blood levels of biologically important trace elements were substantially different in hemodialysis patients, compared with healthy controls.
Since both deficiency and excess of trace elements are potentially harmful yet amenable to therapy, the hypothesis that trace element status influences the risk of adverse clinical outcomes is worthy of investigation.
Further research warranted to confirm findings

Meta-Analysis

DOI

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