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Mo3.5
Molybdenum – Forschung
Hilft wahrscheinlich
27 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Molybdenum scheint in 3 von 4 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1993–2026 mit einer typischen Studiengröße von 400 Teilnehmenden.
Basierend auf 27 Studien · 4 Meta-Analysen · 4 RCTs · 141,373 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
3geholfen1unklar· 23 weitere ohne bewertete Effektdaten
Nach Outcome
Micronutrient & trace-element status
Überwiegend Mechanismus / Beobachtung12 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung9 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung4 Studien
Cholesterol & lipids
Zu wenige bewertete Studien2 Studien
Women's health
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 15 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
141k
typische Studie: 400 Personen
Stärkste Designs
8
4 gepoolt, 4 randomisiert
Zeigte Nutzen
75%
3/4 Studien
Wie lange Studien liefen
3+ Monate
1
Untersuchte Populationen
Bariatric surgery patients1
Adults exposed to metals1
At-risk disease patients1
pregnant women1
Aktives Forschungsgebiet
20 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2023
199320092026
1Mineral deficiency rates after bariatric surgeryMeta-Analysen=47,432 · very large study2023
Einfach gesagt: A high deficiency rate of serum iron, zinc, copper, chlorine, phosphorus, and calcium was seen after bariatric surgery.
Cao L et al. · Obesity surgery (2023)
Groß Nutzen
← SchlechterKein EffektBesser →
The most severe mineral deficiency after bariatric surgery was iron (20.1%), followed by zinc (18.3%), copper (14.4%), chlorine (12.2%), phosphorus (7.5%), and calcium (7.4%).
The difference in surgical procedures, study regions, and follow-up time may affect postoperative mineral status; more targeted mineral supplement programs are needed considering these influencing factors.
2Hyperuricemia risk from metal exposureMeta-Analysen=63,283 · very large study2022
Gu T et al. · Clinical rheumatology (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Data were pooled by random-effects models and expressed as pooled odds ratios (OR) and 95% confidence intervals (CIs).
Exposure to molybdenum (pooled OR = 0.804, 0.724, 0.975, 3, 0%) was linked to a decreased risk of HUA, however.
Molybdenum exposure was associated with a decreased prevalence of HUA; however, aluminum, cobalt, copper, iron, magnesium, manganese, mercury, selenium, thallium and zinc are not associated with HUA risk.
Shiani A et al. · Biological trace element research (2024)
Based on the findings, it is acceptable to infer that maternal exposure to toxic elements, whether through environmental contaminants or dietary sources, was associated with an elevated risk of OFCs.
Furthermore, the study revealed that ETEs exhibited a potential protective role in reducing the incidence of OFCs.
This observation highlights the importance of reducing exposure to toxic elements during pregnancy and suggests that optimizing maternal intake of ETEs could be an effective preventive strategy.
Einfach gesagt: The results of this study showed that the concentration of nutrients in most articles was undesirable.
Aghalari Z et al. · Journal of health, population, and nutrition (2022)
The results of this study showed that the concentration of nutrients in most articles was undesirable.
It is suggested that optimal methods of enrichment of breads and flours be done with interdisciplinary cooperation between food hygiene, environmental health, nutrition, farmers and bakers.
It is recommended that food hygiene and environmental health researchers investigate other nutrients (including phosphorus, selenium, manganese, boron and molybdenum) in breads and other staple foods used by people to constructive and practical measures to increase public health.
Einfach gesagt: However, it can be assumed that altered concentrations of those elements are crucial regarding the onset and exaggeration of either psychotic or negative symptoms or cognitive dysfunctions.
Baj J et al. · International journal of molecular sciences (2020)
This review includes the analysis of serum levels of the following trace elements: iron, nickel, molybdenum, phosphorus, lead, chromium, antimony, uranium, magnesium, aluminum, zinc, copper, selenium, calcium, and manganese.
Currently, there is no consistency regarding serum trace element levels in schizophrenic patients.
Thus, it cannot be considered as a reliable prognostic or diagnostic marker of schizophrenia.
Einfach gesagt: In addition, the report describes the main mechanisms by which metals exert their toxic effects on the body, as well as the primary sources of pollution through which they are released into the environment.
Rojas-Lemus M, López-Valdez N, González-Villalva A, Bizarro-Nevares P, Casarrubias-Tabarez B, Cervantes-Valencia ME, Ustarroz-Cano M, Rivera-Fernández N, Anacleto-Santos J, Chávez-Maya F, Milán-Chávez R, Morales-López S, Fortoul TI. · International journal of molecular sciences (2026)
However, when the organism is overexposed, those same essential metals-in high concentrations that become toxic-cause imbalances or overt pathologies.
On the other hand, there are metals that are not essential in humans, so their presence and accumulation in the organism can cause adverse effects.
In this review we focus on the essentiality and toxicity of the main trace metals such as iron, zinc, copper, manganese, chromium, cobalt, molybdenum, and nickel, as well as on the toxicity of metals such as vanadium, cadmium, and lead that are not essential for humans.
8molybdenum role in gestational complicationsÜbersicht2023
Einfach gesagt: This review summarises the current literature concerning varied recommendations on molybdenum intake, the role of molybdenum and molybdoenzymes in physiology, and the contribution these play in gestational outcomes.
Foteva V et al. · Nutrients (2023)
Overexposure and deficiency can result in adverse health outcomes and mortality, although physiological doses remain largely unexplored in relation to human health.
The lack of knowledge surrounding molybdenum intake and the role it plays in physiology is compounded during pregnancy.
As pregnancy progresses, micronutrient demand increases, and diet is an established factor in programming gestational outcomes and maternal health.
Einfach gesagt: Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Lan L et al. · Journal of cellular and molecular medicine (2024)
Trace elements are minimal yet essential components of human body that cannot be overlooked, and they participate in enzyme activation, DNA synthesis, antioxidant defence, hormone production, etc.
Moreover, trace elements are particularly involved in immune regulations.
Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Einfach gesagt: The current review provides an updated discussion of the plausible mechanisms combining Cu, S, and Mo alterations in AD.
Coelho FC et al. · International journal of molecular sciences (2022)
Alzheimer's disease (AD) and other forms of dementia was ranked 3rd in both the Americas and Europe in 2019 in a World Health Organization (WHO) publication listing the leading causes of death and disability worldwide.
The current review provides an updated discussion of the plausible mechanisms combining Cu, S, and Mo alterations in AD.
Einfach gesagt: The systematic review of the literature does not support the hypothesis that the use of supplements of vitamin C or vitamin E in the doses tested helps prevent and/or treat cancer in the populations tested.
Coulter ID et al. · Journal of general internal medicine (2006)
The systematic review of the literature does not support the hypothesis that the use of supplements of vitamin C or vitamin E in the doses tested helps prevent and/or treat cancer in the populations tested.
There were isolated findings of benefit, which require confirmation.
Einfach gesagt: This study also highlights the potential of crop biofortification as a sustainable, strategy to enhance the nutrient density of vegetables within controlled dietary patterns.
Baldassano S et al. · Nutrients (2025)
Dietary intake was carefully monitored throughout the 12-day period to control for confounding dietary effects.
Results: The intervention was associated with decreased plasma levels of triglycerides, AST, and ALT, and increased plasma levels of HDL-cholesterol and the satiety hormone PYY, suggesting enhanced metabolic regulation.
Conclusions: These biochemical markers reflect early metabolic adaptations that may inform future research on the metabolic impact of micronutrient biofortification.
13Cadmium levels in insulin resistanceFall-Kontrolln=225 · medium study2019
Einfach gesagt: While some toxic metals and trace elements were found to be associated with SLE diagnosis, they had no effect on disease activity and IR.
Pedro EM et al. · Biological trace element research (2019)
Likely real
Levels of Cd were higher in patients with IR (p = 0.042).
There was no significant association between IR and the other metals.
The results indicate that SLE patients have different profiles of trace elements and toxic metals compared to healthy controls.
14Cancer and total mortalityRCTn=29,584 · very large study2018
Einfach gesagt: Multiyear nutrition intervention is unlikely to have a meaningful effect on mortality more than a decade after supplementation ends, even in a nutritionally deprived population.
Wang SM et al. · Journal of the National Cancer Institute (2018)
Kein klarer Effekt
← SchlechterKein EffektBesser →
The protective effect of Factor D for gastric cancer was attenuated (HR = 0.93, 95% CI = 0.85 to 1.01), but a newly apparent protective effect against esophageal cancer was found for Factor B (HR = 0.92, 95% CI = 0.85 to 1.00, two-sided P = .04).
Protective effects were found in people younger than age 55 years at baseline against non-upper gastrointestinal cancer death for Factor A (HR = 0.80, 95% CI = 0.69 to 0.92) and against death from stroke for Factor C (HR = 0.89, 95% CI = 0.82 to 0.96).
In contrast, increased risk of esophageal cancer was found when the intervention began after age 55 years for Factors C (HR = 1.16, 95% CI = 1.04 to 1.30) and D (HR = 1.20, 95% CI = 1.07 to 1.34).
15Lung cancer mortalityRCTn=147 · medium study2006
Einfach gesagt: Supplementation with combinations of vitamins and minerals at nutrient-repletion levels for 5.25 years did not reduce lung cancer mortality in this nutrient-inadequate population in Linxian, China.
Kamangar F et al. · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2006)
Lung cancer deaths (n = 147) identified during the trial period (1986-1991) and 10 years after the trial ended (1991-2001) were the study outcome.
No significant differences in lung cancer death rates were found for any of the four combinations of supplements tested in this study, using log-rank tests (all P values are >0.20) or Cox proportional hazards models adjusted for age, sex, commune, and other treatments.
No significant interactions were seen for age, sex, or smoking status.
Einfach gesagt: At present, available evidence does not support routine assessment of trace element status or generalized supplementation in the prevention or management of allergic diseases, except in cases of documented deficiency or clearly defined clinical indications.
Ordak M, Zemelka-Wiacek M, Kosowska A, Jutel M, Anna K, Michal M, Hubert P, Pawlasek J, Bulska E, Ruszczynska A, Konieczynski P, Wesolowski M, Plenis A, Sousa-Pinto B, Bognanni A, Martini M, Paoletti G, di Bona D, Canonica GW, Bousquet J, Feleszko W, Cieslik M, Leung CWM, Leung TF, Eljaszewicz A. · Allergy (2026)
However, reported associations between elemental status and allergic diseases remain heterogeneous across studies.
This variability likely reflects both underlying biological differences and methodological heterogeneity, including variation in study design, biological matrices, exposure assessment, and analytical techniques.
Better methodological harmonization will be essential to elucidate the roles of trace elements in allergy development and to strengthen future translational and preventive research efforts.
Einfach gesagt: The examination of these mechanisms has provided an impression of the mechanism by which molybdenum treats iron-deficiency anemia and may treat arthritis; and hypothesize uses of molybdenum for other human diseases.
Grech BJ · European journal of clinical nutrition (2021)
This minireview examines three possible underlying mechanisms.
It investigates the possibility that molybdenum: increases the quantity of active mammalian molybdoenzymes, restores or partially restores activity to malfunctioning mammalian molybdoenzymes, or blocks nuclear receptors, in cells.
The examination of these mechanisms has provided an impression of the mechanism by which molybdenum treats iron-deficiency anemia and may treat arthritis; and hypothesize uses of molybdenum for other human diseases.
18Molybdenum enzyme function in redox reactionsÜbersicht2024
Einfach gesagt: Further research into the molecular mechanisms underlying these enzymes' functions could lead to novel treatments and improved patient outcomes.
Adamus JP et al. · Biomolecules (2024)
The newest member of molybdenum-containing enzymes is mitochondrial amidoxime-reducing component (mARC), involved in drug metabolism and detoxification reactions.
Emerging evidence suggests its involvement in liver pathologies such as HCC and NAFLD, indicating its potential as a therapeutic target.
Overall, understanding the roles of molybdenum-containing enzymes in human physiology and disease pathology is essential for advancing diagnostic and therapeutic strategies for various health conditions, particularly those related to liver dysfunction.
19Trace element deficiency manifestationsÜbersicht2024
Einfach gesagt: This text summarises the most relevant clinical manifestations of trace element depletion and deficiency, the difficulties in assessing status, and makes practical recommendations for provision for enteral and parenteral nutrition.
Shenkin A et al. · Clinical nutrition ESPEN (2024)
This text summarises the most relevant clinical manifestations of trace element depletion and deficiency, the difficulties in assessing status, and makes practical recommendations for provision for enteral and parenteral nutrition.
20Molybdenum-copper antagonism in metalloproteinsÜbersicht2024
Einfach gesagt: Therefore, this review aims to connect the Mo-Cu antagonism in metalloproteins and anti-copper therapy.
Maiti BK et al. · Chembiochem : a European journal of chemical biology (2024)
However, this interaction was first observed in ruminants, and they convert molybdate (MoO4 2- ) into tetrathiomolybdate (MoS4 2- ; TTM), reacting with cellular Cu to yield biological unavailable Mo/S/Cu cluster, then developing Cu-deficiency diseases.
These findings inspire the use of TTM as a Cu-sequester drug, especially for treating Cu-dependent human diseases such as Wilson diseases (WD) and cancer.
It is well known that a balanced Cu homeostasis is essential for a wide range of biological processes, but negative consequence leads to cell toxicity.