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Msm6.0
MSM – Forschung
Hilft vermutlich
31 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
MSM half in etwa der Hälfte (2/3) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 70 Teilnehmenden.
Basierend auf 31 Studien · 2 Meta-Analysen · 24 RCTs · 8,593 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen1unklar· 28 weitere ohne bewertete Effektdaten
Nach Outcome
Joint pain & arthritisVerringert Arthroseschmerzen und verbessert die körperliche Funktion · 4-8 Wochen
Hilft vermutlich30 Studien
RecoveryReduzierter Muskelkater nach dem Training · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung6 Studien
InflammationReduzierte Gelenkschmerzen und Steifheit · 4-12 Wochen
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Skin healthSchwefeldonor unterstützt die Kollagen- und Keratinsynthese · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Cholesterol & lipids
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Endurance & exercise performance
Zu wenige bewertete Studien1 Studie
Therapeutic & clinical
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
Immune support
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 13 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
80%
über Studien hinweg
Untersuchte Personen
8,593
typische Studie: 70 Personen
Stärkste Designs
26
2 gepoolt, 24 randomisiert
Zeigte Nutzen
67%
2/3 Studien
Wie lange Studien liefen
1–3 Monate
4
Untersuchte Populationen
Patients with osteoarthritis1
Chronic bacterial prostatitis patients1
Patients with knee osteoarthritis grade I-II1
Patients with stage I-III primary knee osteoarthritis1
Aktives Forschungsgebiet
17 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200620162026
1WOMAC pain score improvementMeta-Analysen=2,455 · very large study2025
Einfach gesagt: Passion fruit peel extract was the best supplement for improving WOMAC pain and function scores in patients with osteoarthritis, followed by Lanconone and collagen.
Chen CS et al. · Journal of integrative medicine (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
In the WOMAC pain score, the SUCRA of passion fruit peel extract was 91% (mean difference [MD]: -9.2; 95% confidence interval [CI]: [-16.0, -2.3]), followed by methylsulfonylmethane (89%), undenatured type II collagen (87%), collagen (84%), and Lanconone (82%).
The SUCRA (99%) of passion fruit peel extract (MD: -41.0; 95% CI: [-66.0, -16.0]) ranked first in terms of the WOMAC function score, followed by Lanconone (95%), collagen (86%), ParActin (84%), and Lactobacillus casei strain Shirota (83%).
The top three total rankings are passion fruit peel extract (95.0%), Lanconone (88.5%), and collagen (85.0%).
Einfach gesagt: The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low.
Liu X et al. · British journal of sports medicine (2018)
Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and chondroitin) revealed statistically significant improvements on pain, but were of unclear clinical importance.
Chondroitin demonstrated statistically significant, but not clinically important structural improvement (effect size -0.30, -0.42 to -0.17).
The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low.
Einfach gesagt: The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its molecular mechanisms of actions and data of efficacy and safety (when available).
Colletti A et al. · International journal of molecular sciences (2021)
It is characterized by pain, stiffness, and a reduced range of motion with regard to the arthritic joints.
These symptoms can cause in the long term a greater risk of overweight/obesity, diabetes mellitus, and falls and fractures.
The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its molecular mechanisms of actions and data of efficacy and safety (when available).
6Clinical efficacy of levofloxacin in chronic bacterial prostatitisRCTn=79 · small study2016
Einfach gesagt: The combination of serenoa repens, selenium, lycopene + bromelain and methylsulfonylmethane extracts improved the clinical efficacy of levofloxacin in patients affected by CBP without the development of side effects.
Cai T et al. · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica (2016)
Likely real
At the second follow-up visit (T2), questionnaire results demonstrated statistically significant differences between groups (p < 0.001).
One patient in Group A (2.5%) and 7 patients (17.9%) in Group B showed a symptomatic and microbiological recurrence (p = 0.02).
The combination of serenoa repens, selenium, lycopene + bromelain and methylsulfonylmethane extracts improved the clinical efficacy of levofloxacin in patients affected by CBP without the development of side effects.
Einfach gesagt: combination of glucosamine-chondroitinsulfate-methylsulfonylmethane showed clinical benefit for patients with knee OAK ellgren-Lawrence grade I-II compared with GC and placebo.
Lubis AMT et al. · Acta medica Indonesiana (2017)
Likely real
on statistical analysis it was found that at the 12th week, there are significant difference between three treatment groups on the WOMAC score (p=0.03) and on the VAS score (p=0.004).
When analyzed between weeks, GCM treatment group was found statistically significant on WOMAC score (p=0.01) and VAS score (p<0.001).
Comparing the score difference between weeks, WOMAC score analysis showed significant difference between GC, GCM, and placebo in week 4 (p=0.049) and week 12 (p=0.01).
Einfach gesagt: Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol.
Miller L et al. · Nutrients (2021)
The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013).
Measurements occurred at baseline and after 4, 8, and 16 weeks.
Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status.
19Hand pain in symptomatic hand osteoarthritisRCTn=106 · medium study2021
Einfach gesagt: There were no significant differences in symptomatic relief between the two groups over 12 weeks.
Liu X et al. · Osteoarthritis and cartilage (2021)
Kein klarer Effekt
← SchlechterKein EffektBesser →
One hundred and six participants were included with mean age 65.6 years and 81% were women. 45% of the participants were graded as KLG 4, 40% KLG three and 39 (37%) had erosive OA.
The adjusted between group difference in means (95%CI) was 5.34 (-2.39 to 13.07).
Five participants (10%) in the supplement combination group discontinued study treatment due to AE vs four participants (7%) in the placebo group.
Einfach gesagt: This RCT provides direct evidence for MSM's effects on cartilage biomarkers in knee osteoarthritis, strengthening its clinical profile.
Toguchi A et al. · Journal of the International Society of Sports Nutrition (2024)
MSM supplementation significantly reduced serum cartilage oligomeric matrix protein (COMP) levels versus placebo
Self-reported knee pain and function scores improved significantly in the MSM group
No serious adverse events were reported in either group