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Nac6.0
NAC – Forschung
Hilft wahrscheinlich
806 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
NAC scheint in 5 von 6 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1982–2026 mit einer typischen Studiengröße von 302 Teilnehmenden.
Basierend auf 803 Studien · 134 Meta-Analysen · 610 RCTs · 24,173 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
5geholfen1unklar· 797 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung158 Studien
InflammationFüllt Glutathion auf, unterstützt die Phase-II-Entgiftung · 2-4 weeks
Überwiegend Mechanismus / Beobachtung110 Studien
Kidney & renal health
Überwiegend Mechanismus / Beobachtung104 Studien
Respiratory & lung
Überwiegend Mechanismus / Beobachtung91 Studien
RecoveryGlutathion-Auffüllung stärkt die Funktion der Immunzellen · 2-4 weeks
2Incidence of anti-TB drug induced liver injuryMeta-Analysen=3,423 · very large study2023
Einfach gesagt: This meta-analysis examined the effects of NAC.
Akkahadsee P et al. · Scientific reports (2023)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
The NMA indicated that supplementation of Turmeric plus Tinospora cordifolia (RR 0.07; 95% CI 0.02 to 0.28), and N-acetyl cysteine (NAC) (RR 0.09; 95% CI 0.01 to 0.75) significantly reduced the incidence of anti-TB DILI compared with placebo.
In addition, poly herbal product significantly reduced alkaline phosphatase (ALP) (MD - 21.80; 95% CI - 33.80 to - 9.80) and total bilirubin (Tbil) compared with placebo (MD - 0.51; 95% CI - 0.76 to - 0.26).
There was no statistically significant difference in the occurrence of AEs in any intervention.
3H. pylori eradicationMeta-Analysen=1,167 · large study2022
Einfach gesagt: Adjuvant NAC plus standard treatment protocols are not superior to standard treatment protocols for H. pylori eradication.
Biswas DP et al. · Clinics and research in hepatology and gastroenterology (2022)
Adjuvant NAC plus standard treatment protocols are not superior to standard treatment protocols for H. pylori eradication.
These findings are consistent with the use of adjuvant NAC with 'currently used standard treatment protocols' (clarithromycin-based triple therapies) and also with adjuvant NAC used in the treatment of naïve patients.
4Recovery biomarkers (CK-MB)Meta-Analysen=1,388 · large study2022
Einfach gesagt: However, subgroup analyses based on NAC dosage indicated the meaningful effect of NAC on CK-MB at the dosage of ≥100 mg/kg.
Nejati M et al. · Journal of food biochemistry (2022)
PRACTICAL APPLICATIONS: Previous studies on the influence of NAC administration on recovery biomarkers have presented conflicting results.
This systematic review and meta-analysis offers a broad range of detailed information on the influence of chronic and acute NAC supplementation outcomes regarding recovery biomarkers.
Overall, the results support that NAC supplementation may not be effective in improving recovery biomarkers.
5Treatment of idiopathic asthenozoospermiaMeta-Analysen=621 · large study2021
Einfach gesagt: Moreover, NAC has a positive effect on sperm concentration and ejaculate volume, whereas no obvious effect was observed in serum hormones.
Wei G et al. · American journal of men's health (2021)
Likely real
Besides, NAC had a significantly greater increase in sperm concentration (p < .00001) and ejaculate volume (p = .002) compared with the placebo group, and there was no significant difference in LC/LAC.
For the analysis of serum hormones, NAC had no obvious differences in improving the serum testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin compared with non-treatment group.
Conclusively, LC/LAC and NAC showed a greater improvement in sperm motility and normal morphology.
6Exacerbation frequency in chronic respiratory conditionsMeta-Analysen=4,155 · very large study2015
Einfach gesagt: Patients treated with NAC had significantly and consistently fewer exacerbations of chronic bronchitis or COPD (relative risk 0.75, 95% CI 0.66-0.84; p<0.01).
Cazzola M, Calzetta L, Page C, Jardim J, Chuchalin AG, Rogliani P, Matera MG · European Respiratory Review (2015)
13Chronic bronchitis exacerbationsMeta-Analysen=775 · large study2019
Einfach gesagt: There is a role for NAC treatment in the management of CB by reducing symptoms and exacerbations compared with placebo, without increasing the risk of adverse effects.
Wei J et al. · Advances in therapy (2019)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The pooled analysis demonstrated significant evidence that NAC reduced the frequency of CB exacerbations (RR = 0.81, 95% CI 0.69-0.93, P = 0.004).
Patients treated with NAC had significant symptom improvement compared with controls (RR = 1.68, 95% CI 1.13-2.52, P = 0.01).
NAC did not significantly increase the risk of adverse effects compared with placebo (RR 0.86, 95% CI 0.67-1.09, P = 0.22).