54 peer-reviewed studies · Evidence score: 8/10
Viña I et al. • Nutrients (2025)
NAC had a major effect on progesterone, endometrial thickness, and LH levels in women with PCOS.
Abu Hasna A et al. • Odontology (2025)
The Author(s), under exclusive licence to The Society of The Nippon Dental University.
Gakuba C et al. • Journal of cardiovascular pharmacology (2024)
Pooled analysis demonstrated a reduction of in-hospital mortality associated with NAC: odds ratio, 0.60; 95% confidence interval, 0.39-0.92; P = 0.02.
Paraskevas T et al. • Romanian journal of internal medicine = Revue roumaine de medecine interne (2023)
The certainty of evidence in the included studies was very low, thus recommendations for clinical practice cannot be yet made.
Akkahadsee P et al. • Scientific reports (2023)
This meta-analysis examined the effects of NAC.
Peng TR et al. • General hospital psychiatry (2024)
Our findings indicate that adjunctive NAC can ameliorate depressive symptoms in patients with psychiatric problems, particularly bipolar disorder.
Winterlind EL et al. • Addiction biology (2024)
Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
Biswas DP et al. • Clinics and research in hepatology and gastroenterology (2022)
Adjuvant NAC plus standard treatment protocols are not superior to standard treatment protocols for H. pylori eradication.
Nejati M et al. • Journal of food biochemistry (2022)
However, subgroup analyses based on NAC dosage indicated the meaningful effect of NAC on CK-MB at the dosage of ≥100 mg/kg.
Pang Q et al. • PloS one (2022)
CH related treatments may have advantages in the treatment of IPF and CH + NAC may have clinical application value.
Jiang SJ et al. • International heart journal (2021)
There was no significant difference in the occurrence of adverse reactions between the NAC group and the control group [RR = 1.04, 95%CI (0.57-1.89), P = 0.90].NAC can reduce the all-cause mortality and MACE cases of STEMI.
Wei G et al. • American journal of men's health (2021)
Moreover, NAC has a positive effect on sperm concentration and ejaculate volume, whereas no obvious effect was observed in serum hormones.
Li Y et al. • Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association (2019)
As premedication of gastroscopy, simethicone plus NAC offers more benefit on positive findings and total mucosal visibility score.
Pereira JEG et al. • PloS one (2019)
The addition of NAC during cardiac surgery did not result in a statistically significant reduction in clinical outcomes.
Plane J et al. • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2025)
Our findings suggest that, regardless of administration route, current published evidence does not show that NAC is effective in preventing CIHL in the standard clinical audiogram range.
Koh A et al. • ANZ journal of surgery (2024)
The administration of NAC in liver resection did not alter important biochemical parameters suggesting any real effectiveness in reducing hepatic dysfunction.
He T et al. • British journal of hospital medicine (London, England : 2005) (2024)
Conclusion This meta-analysis demonstrated the efficacy of NAC in reducing inflammatory markers, improving joint tenderness, and swelling in patients with RA.
Cazzola M et al. • European Respiratory Review (2015)
NAC has mucolytic properties and reduces exacerbations in chronic respiratory conditions.
Magner K et al. • JAMA network open (2022)
In this meta-analysis, NAC was associated with a benefit in the prevention of CI-AKI.
Wei J et al. • Advances in therapy (2019)
There is a role for NAC treatment in the management of CB by reducing symptoms and exacerbations compared with placebo, without increasing the risk of adverse effects.