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Nattokinase (from Natto)
Enzyme from Japanese fermented soybeans that supports healthy blood flow and may help break down fibrin.
What the evidence says
Studies are split: Nattokinase helped in 1 of 3 cases, with the rest inconclusive or showing no benefit.
Most evidence is from high-quality randomised trials published 2008–2026 with a typical study size of 73 participants.
Based on 25 studies · 11 RCTs · 1,029 total participants
Confidence
HighWhat the studies found
By outcome
Nattokinase has an evidence score of 8.5/10 — very strong evidence based on 25 indexed studies. Enzyme from Japanese fermented soybeans that supports healthy blood flow and may help break down fibrin.
The commonly studied dose of Nattokinase is 2000-4000 FU (fibrinolytic units). Research points to an estimated optimal dose around 4000FU, with a minimum effective dose near 2000FU. Individual response varies — start low and adjust.
The best time to take Nattokinase is in the evening. It can be taken on an empty stomach. Nattokinase is a fibrinolytic serine protease enzyme derived from natto (Bacillus subtilis-fermented soybeans).
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Last reviewed May 2026 · evidence from 29 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Nattokinase is a fibrinolytic enzyme extracted from natto, a traditional Japanese fermented soybean food. It has potent effects on blood clot breakdown and may support cardiovascular health by improving blood flow. Popular in longevity circles for its blood-thinning properties without the side effects of pharmaceutical anticoagulants.
Directly breaks down fibrin in blood clots
May modestly reduce blood pressure
How Nattokinase works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
2000-4000 FU (fibrinolytic units)
Can be taken without food
| Form | Type |
|---|---|
| 💊Capsules standardized to FU | Recommended |
| 💊Natto food | Alternative |
Look for products standardized to fibrinolytic units (FU) rather than just mg.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Taking on empty stomach may improve absorption. Avoid taking with blood thinners.
Based on fibrinolytic activity demonstrated in multiple studies. Conservative estimate given limited direct circulation measurements. One RCT (n=153) showed clinical symptom improvement. Bleeding risk may increase with dose due to fibrinolytic mechanism.
Better circulation throughout body
Modest BP reduction in some
Avoid — may increase bleeding risk
Stop at least 2 weeks before any surgery
Significantly increases bleeding risk
May have additive effects
Tip: Reduce dose; stop if concerning
Tip: Take with small amount of food
Nattokinase is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are easy bruising, GI upset. Use caution if any of these apply to you: Bleeding disorders; Before surgery (stop 2 weeks prior); Those on anticoagulants.
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