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Nem3.0
Neem Research
Mostly mechanism / observational
20 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Neem studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1982–2026.
Based on 20 studies · 1 meta-analysis · 14 RCTs
Confidence
Moderate confidence
By outcome
Skin healthTraditional use for skin and antimicrobial action; human skin-condition trials are limited · Weeks (limited data)
Too few graded studies1 study
Active research area
8 studies in the last 5 years · Latest meta-analysis: 2022
198220042026
1Meta-Analysis2022
Ramli H, Nor Aripin KN, Mohd Said S, Mohamad Hanafiah R, Mohd Dom TN · J Ethnopharmacol (2022)
In plain English: By bringing together existing evidence, it emphasizes the promise of plant-derived compounds as sustainable, cost-effective antivirals for poultry health management.
Singh R, Sonu SS, Rangan L. · Archives of virology (2026)
Several plants, including Pongamia pinnata (karanj), Withania somnifera (ashwagandha), Psidium guajava and Azadirachta indica (neem) have shown promising anti-NDV activity.
Their bioactive compounds, such as karanjin, quercetin, withanine, eugenol and azadirachtin, can interfere with viral entry, replication, protein synthesis, or enhance host immune responses in in vitro, in ovo, and in silico models.
This review consolidates current knowledge on active phytochemicals from various medicinal plants against NDV, highlighting their mechanistic insights and therapeutic potential.
In plain English: The purpose of this review is to gather all the information available about Azadirachta indica, including its distribution, botanical description, commercial use, and medicinal properties.
Mehnaz S, Shamsi Y, Akhtar MW, Mohanty S, Ahmad S. · Advances in mind-body medicine (2024)
Almost every part of the tree can be used as medicine, including its leaves, flowers, seeds, fruits, roots, and bark, both locally and systemically after being properly processed in pharmaceutical industries.
Apart from treating various skin ailments like dermatitis, eczema, acne, and fungal and bacterial infections, it also exhibits anti-malarial, anticancer, antifertility, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, neuroprotective, and wound healing properties.
In modern times, it is also used in cosmetics, toiletries, and pharmaceutical products.
19RCT2020
In plain English: Neem significantly reduced postprandial and fasting blood sugar, HbA1c, and insulin resistance compared to placebo, on top of metformin therapy.
Pingali U, Ali MA, Gundagani S, Nutalapati C · Diabetes Metab Syndr Obes (2020)
Randomized, double-blind, placebo-controlled trial in 80 type 2 diabetes patients on metformin
Neem extract (125, 250, 500 mg twice daily for 12 weeks) significantly improved fasting/postprandial glucose, HbA1c, and insulin resistance vs placebo
Also improved endothelial function and markers of inflammation; no effect on lipids or platelet aggregation