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Nem3.0

Neem Research

Mostly mechanism / observationalLimited safety

4 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Neem studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 1982–2021.

Based on 4 studies · 1 RCT

Confidence

Low

Steady research

1 study in the last 5 years

198220012021

1Systematic Reviewn=20 RCTs · very large study2021

Azadirachta indica was among five herbal products that showed better results than chlorhexidine in reducing dental plaque and gingival inflammation.

Santi SS, Casarin M, Grellmann AP, Chambrone L, Zanatta FB · Oral Dis (2021)

Systematic review of 20 RCTs of herbal mouthrinses for plaque and gingivitis
Herbal rinses including Azadirachta indica (neem) significantly reduced plaque and gingival inflammation versus placebo
Unclear risk of bias in most trials precludes definitive conclusions

View source

2Systematic Reviewn=3 RCTs · very large study2017

Neem mouthrinse was as effective as chlorhexidine mouthrinse when used as an adjunct to toothbrushing in reducing plaque and gingival inflammation in gingivitis patients.

Dhingra K, Vandana KL · Int J Dent Hyg (2017)

Systematic review of RCTs on neem mouthrinse for plaque and gingivitis control
Three included RCTs reported neem rinse comparable to chlorhexidine as an adjunct to brushing
Authors caution the evidence is limited with unclear risk of bias and call for higher-quality trials

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3RCTn=80 patients · very large study2020

Neem significantly reduced postprandial and fasting blood sugar, HbA1c, and insulin resistance compared to placebo, on top of metformin therapy.

Pingali U, Ali MA, Gundagani S, Nutalapati C · Diabetes Metab Syndr Obes (2020)

Randomized, double-blind, placebo-controlled trial in 80 type 2 diabetes patients on metformin
Neem extract (125, 250, 500 mg twice daily for 12 weeks) significantly improved fasting/postprandial glucose, HbA1c, and insulin resistance vs placebo
Also improved endothelial function and markers of inflammation; no effect on lipids or platelet aggregation

View source

4Case Study1982

This case report documents a fatal Reye-like syndrome attributed to margosa (neem) oil poisoning, with postmortem findings.

Sinniah D, Baskaran G, Looi LM, Leong KL · Am J Gastroenterol (1982)

Case report of fatal Reye-like syndrome following neem (margosa) oil ingestion
Documents the hepatic and encephalopathic toxicity that has been repeatedly described with neem oil, especially in children
Underlies the firm warning against ingesting neem oil and against use in infants/young children

View in Research Library

Neem Research

Mostly mechanism / observational

Effect of herbal mouthrinses on dental plaque formation and gingival inflammation: A systematic review.

Effectiveness of Azadirachta indica (neem) mouthrinse in plaque and gingivitis control: a systematic review.

Evaluation of the Effect of an Aqueous Extract of Azadirachta indica (Neem) Leaves and Twigs on Glycemic Control, Endothelial Dysfunction and Systemic Inflammation in Subjects with Type 2 Diabetes Mellitus - A Randomized, Double-Blind, Placebo-Controlled Clinical Study.

Reye-like syndrome due to margosa oil poisoning: report of a case with postmortem findings.