1Meta-Analysis2018
Zhang Y, Ma T, Zhang P · Medicine (Baltimore) (2018)
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106 peer-reviewed studies
What the evidence says
Most Nicotinamide studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1980–2026 with a typical study size of 43 participants.
Based on 106 studies · 4 meta-analyses · 86 RCTs · 8,363 total participants
Confidence
High confidenceWhat the studies found
By outcome
32 studies in the last 5 years · Latest meta-analysis: 2025
Zhang Y, Ma T, Zhang P · Medicine (Baltimore) (2018)
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Pozzilli P, Browne PD, Kolb H · Diabetes Care (1996)
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Hussain S, Singh A, Alshammari TM, Habib A, Hussain MS, Jha R · Saudi J Kidney Dis Transpl (2020)
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Liu H, Yu H, Xia J, Liu L, Liu G, Sang H · J Evid Based Med (2020)
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Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K · Br J Dermatol (2002)
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Pozzilli P, Visalli N, Cavallo MG, Signore A, Baroni MG, Buzzetti R · Eur J Endocrinol (1997)
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Morganti P, Berardesca E, Guarneri B, Guarneri F, Fabrizi G, Palombo P · Int J Cosmet Sci (2011)
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Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P · J Clin Oncol (2012)
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Olmos PR, Hodgson MI, Maiz A, Manrique M, De Valdés MD, Foncea R · Diabetes Res Clin Pract (2006)
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Hoskin PJ, Saunders MI, Dische S · Cancer (1999)
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Saunders MI, Hoskin PJ, Pigott K, Powell ME, Goodchild K, Dische S · Radiother Oncol (1997)
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Philips JC, Scheen AJ · Rev Med Liege (2002)
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Visalli N, Cavallo MG, Signore A, Baroni MG, Buzzetti R, Fioriti E · Diabetes Metab Res Rev (1999)
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Mohammed D, Crowther JM, Matts PJ, Hadgraft J, Lane ME · Int J Pharm (2013)
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Thanos SM, Halliday GM, Damian DL · Br J Dermatol (2012)
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Ix JH, Isakova T, Larive B, Raphael KL, Raj DS, Cheung AK · J Am Soc Nephrol (2019)
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Hoskin PJ, Rojas AM, Bentzen SM, Saunders MI · J Clin Oncol (2010)
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Taboga C, Tonutti L, Noacco C · Recenti Prog Med (1994)
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Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J · J Cosmet Dermatol (2009)
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Drago F, Ciccarese G, Cogorno L, Calvi C, Marsano LA, Parodi A · Eur J Dermatol (2017)
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