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Non2.0

Noni Research

Mostly mechanism / observationalLimited safety

4 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Noni studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from mixed-quality randomised trials published 2005–2009 with a typical study size of 2 participants.

Based on 4 studies · 1 RCT · 288 total participants

Confidence

Low

Older research base

Newest study from 2009

20052009

1Case Studyn=2 · very small study2005

Two patients developed liver injury after noni-juice consumption — one required urgent liver transplantation after sub-acute hepatic failure.

Stadlbauer V, Fickert P, Lackner C, Schmerlaib J, Krisper P, Trauner M, Stauber RE · World J Gastroenterol (2005)

Two-case series of noni-associated hepatotoxicity
A 29-year-old man developed sub-acute hepatic failure after 1.5 L over 3 weeks and required liver transplantation
A 62-year-old woman had self-limited acute hepatitis after 2 L over 3 months

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2Case Studyn=1 · very small study2006

A 24-year-old woman developed fulminant hepatitis after 4 weeks of noni juice taken for 'immune stimulation'; liver enzymes normalized after she stopped.

Yuce B, Gulberg V, Diebold J, Gerbes AL · Digestion (2006)

Single case report of fulminant hepatitis temporally linked to noni juice
Viral, metabolic and autoimmune hepatitis were excluded and biopsy indicated drug-induced toxicity, though the patient was concurrently on interferon beta-1a (a competing hepatotoxic exposure), weakening causal attribution to noni
Transaminases normalized within a month of stopping noni juice

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3RCTn=285 · medium study2009

Noni juice reduced plasma superoxide anion radicals and lipid hydroperoxides in heavy smokers over 30 days — surrogate oxidative-stress markers only, in a manufacturer-conducted trial.

Wang MY, Lutfiyya MN, Weidenbacher-Hoper V, Anderson G, Su CX, West BJ · Chem Cent J (2009)

30-day randomized, double-blind, placebo-controlled trial in 285 heavy smokers
Reduced plasma superoxide anion radicals and lipid hydroperoxides vs placebo
Endpoints were surrogate oxidative-stress markers, not clinical or immune outcomes

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4Preclinical2009

A manufacturer-conducted study reported no hepatotoxicity of freeze-dried noni puree in HepG2 cells or rats, concluding adverse liver effects are 'unlikely'.

West BJ, Su CX, Jensen CJ · J Toxicol Sci (2009)

In-vitro (HepG2) and subchronic oral toxicity test in Sprague-Dawley rats
No reduction in cell viability and no histopathological liver changes reported
NOAEL for freeze-dried puree reported as >6.86 g/kg

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View in Research Library

Noni Research

Mostly mechanism / observational

Hepatotoxicity of NONI juice: report of two cases.

Hepatitis induced by Noni juice from Morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg?

Antioxidant activity of noni juice in heavy smokers.

Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia (noni) fruit.