Ole8.5

Olive Leaf Extract

botanical

Olive Leaf Extract (Oleuropein)

Oleuropein-rich extract with antiviral, antibacterial, and blood pressure-lowering effects — part of the Mediterranean diet's protective profile.

immunityantimicrobialimmuneblood pressureantioxidant

40+ studies

Evidence

Reviewed 19 days ago

high

Safety

500-1000mg (standardized to 15-20% oleuropein)

Dose

4-8 weeks

Time to Effect

Standardized extract (15-20% oleuropein)

Best Form

Olive Leaf Extract contains oleuropein and other polyphenols that provide antimicrobial, antioxidant, and cardiovascular benefits. Used traditionally for infections and immune support, modern research confirms antiviral, antibacterial, and blood pressure benefits. Part of the Mediterranean diet's protective effects.

Mechanisms of Action

🦠

Antimicrobial Activity

Direct action against bacteria, viruses, and fungi

❤️

ACE Inhibition

Helps relax blood vessels

Biological PathwayBeta

How Olive Leaf Extract works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Recommended Dose

500-1000mg (standardized to 15-20% oleuropein)

500mg1500mg

Optimal Timing

With meals

Take with food

Available Forms

Form	Type
💊Standardized extract (15-20% oleuropein)	Recommended
💊Dried leaf	Alternative
💧Tincture	Alternative

Standardized extracts are more consistent. Higher oleuropein content means higher potency.

Duration

Minimum: 4 weeks

Optimal: 8 weeks

Cycling: Not required

Note: Can be taken any time. Split dosing (2-3 times daily) may be beneficial.

🛡️

Immune Support

Enhanced resistance to infections

⏱️ 2-4 weeks

55% of users notice thispositive

📉

Blood Pressure Support

Modest BP reduction

⏱️ 8 weeks

50% of users notice thispositive

High SafetyMax safe dose: Up to 1500mg/day used safely

🟡

Pregnant/nursing

Insufficient data; consult doctor

Who Should NOT Take This

Known allergy or hypersensitivity to Olive Leaf Extract or related compounds
Pregnancy and breastfeeding
Low blood pressure (may lower BP further)

Drug Interactions

Blood pressure medicationsmild

May have additive effects

Diabetes medicationsmild

May affect blood sugar

Possible Side Effects

GI upset

milduncommon

Tip: Take with food

Herxheimer reaction (die-off)

milduncommon

Tip: Start with lower dose

Warnings

May cause die-off symptoms initially if addressing infections
Start low and increase gradually

⟡ Vitamin C

complementary

Both support immune function

Enhanced immune protection

Top studies from 40+ peer-reviewed papers

📚meta-analysisn=594

DOI

Frumuzachi O et al. • Critical reviews in food science and nutrition (2025)

“Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.”

Key Findings:

Fourteen human intervention studies with 594 participants were included.
Subgroup analysis showed that, in certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, and cardiometabolic disease individuals, while intervention compound, type of intervention, and duration might have differential effects regarding considered outcomes.
Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.

📚systematic-review

DOI

Ussia S et al. • Nutrients (2025)

“Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.”

Key Findings:

The beneficial effect was attributed to the polyphenols contained in EVOO.
Indeed, EVOO supplementation as part of the Mediterranean diet could improve patients' quality of life in secondary prevention by demonstrating a positive correlation with the cardioprotective role of polyphenols.
Discussion: A balanced diet with VOO represents a simple yet potent method to counteract metabolic dysfunctions associated with CVD.
Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.

📚meta-analysisn=703

DOI

Álvares AA et al. • Nutrition reviews (2024)

“In the meta-analysis, fasting glycemia, as evaluated in studies using a low dose of OLE, showed a significant result favoring the control group.”

Key Findings:

In the meta-analysis, fasting glycemia, as evaluated in studies using a low dose of OLE, showed a significant result favoring the control group.
To obtain more consistent results, further clinical studies in humans, using similar methodologies, are required.
Further research warranted to confirm findings

📊rctn=105

DOI

Angelopoulos N et al. • Nutrients (2023)

“Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.”

Key Findings:

LDL-C decreased by 26.46% on average (p < 0.001) during treatment with 10 mg of monacolin and by 16.77% on average during treatment with 3 mg of monacolin (p < 0.001).
We observed a slight but significant reduction of the triglyceride levels only in the high-dose-treated group (mean -4.25%; 95% CI of mean -11.11 to 2.61).
No severe adverse events occurred during the study.
Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.

📋crossovern=500

DOI

Wong RH et al. • Nutrients (2014)

“Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits.”

Key Findings:

Baseline clinic BP in 37 overweight middle-aged men and women who completed the trial averaged 145/84 mmHg.
There was no significant effect of treatment on ABP or any other outcome measure.
The failure to confirm prior evidence of the antihypertensive benefits of these extracts emphasises the importance of placebo control and the value of ABP monitoring.
Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits.

View all 40+ studies

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Ole8.5

Olive Leaf Extract

botanical

Olive Leaf Extract (Oleuropein)

Oleuropein-rich extract with antiviral, antibacterial, and blood pressure-lowering effects — part of the Mediterranean diet's protective profile.

immunityantimicrobialimmuneblood pressureantioxidant

40+ studies

Evidence

Reviewed 19 days ago

high

Safety

500-1000mg (standardized to 15-20% oleuropein)

Dose

4-8 weeks

Time to Effect

Standardized extract (15-20% oleuropein)

Best Form

Mechanisms of Action

🦠

Antimicrobial Activity

Direct action against bacteria, viruses, and fungi

❤️

ACE Inhibition

Helps relax blood vessels

Biological PathwayBeta

How Olive Leaf Extract works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Supplement

Molecular Target

Biological Process

Health Outcome

Strong

Moderate

Emerging

strong

moderate

emerging

Tap node to isolate • Pinch to zoom • Tap edge for research

Recommended Dose

500-1000mg (standardized to 15-20% oleuropein)

500mg1500mg

Optimal Timing

With meals

Take with food

Available Forms

Form	Type
💊Standardized extract (15-20% oleuropein)	Recommended
💊Dried leaf	Alternative
💧Tincture	Alternative

Standardized extracts are more consistent. Higher oleuropein content means higher potency.

Duration

Minimum: 4 weeks

Optimal: 8 weeks

Cycling: Not required

Note: Can be taken any time. Split dosing (2-3 times daily) may be beneficial.

🛡️

Immune Support

Enhanced resistance to infections

⏱️ 2-4 weeks

55% of users notice thispositive

📉

Blood Pressure Support

Modest BP reduction

⏱️ 8 weeks

50% of users notice thispositive

High SafetyMax safe dose: Up to 1500mg/day used safely

🟡

Pregnant/nursing

Insufficient data; consult doctor

Who Should NOT Take This

Known allergy or hypersensitivity to Olive Leaf Extract or related compounds
Pregnancy and breastfeeding
Low blood pressure (may lower BP further)

Drug Interactions

Blood pressure medicationsmild

May have additive effects

Diabetes medicationsmild

May affect blood sugar

Possible Side Effects

GI upset

milduncommon

Tip: Take with food

Herxheimer reaction (die-off)

milduncommon

Tip: Start with lower dose

Warnings

May cause die-off symptoms initially if addressing infections
Start low and increase gradually

⟡ Vitamin C

complementary

Both support immune function

Enhanced immune protection

Top studies from 40+ peer-reviewed papers

📚meta-analysisn=594

DOI

Frumuzachi O et al. • Critical reviews in food science and nutrition (2025)

“Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.”

Key Findings:

Fourteen human intervention studies with 594 participants were included.
Subgroup analysis showed that, in certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, and cardiometabolic disease individuals, while intervention compound, type of intervention, and duration might have differential effects regarding considered outcomes.
Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.

📚systematic-review

DOI

Ussia S et al. • Nutrients (2025)

“Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.”

Key Findings:

The beneficial effect was attributed to the polyphenols contained in EVOO.
Indeed, EVOO supplementation as part of the Mediterranean diet could improve patients' quality of life in secondary prevention by demonstrating a positive correlation with the cardioprotective role of polyphenols.
Discussion: A balanced diet with VOO represents a simple yet potent method to counteract metabolic dysfunctions associated with CVD.
Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.

📚meta-analysisn=703

DOI

Álvares AA et al. • Nutrition reviews (2024)

“In the meta-analysis, fasting glycemia, as evaluated in studies using a low dose of OLE, showed a significant result favoring the control group.”

Key Findings:

In the meta-analysis, fasting glycemia, as evaluated in studies using a low dose of OLE, showed a significant result favoring the control group.
To obtain more consistent results, further clinical studies in humans, using similar methodologies, are required.
Further research warranted to confirm findings

📊rctn=105

DOI

Angelopoulos N et al. • Nutrients (2023)

“Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.”

Key Findings:

LDL-C decreased by 26.46% on average (p < 0.001) during treatment with 10 mg of monacolin and by 16.77% on average during treatment with 3 mg of monacolin (p < 0.001).
We observed a slight but significant reduction of the triglyceride levels only in the high-dose-treated group (mean -4.25%; 95% CI of mean -11.11 to 2.61).
No severe adverse events occurred during the study.
Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.

📋crossovern=500

DOI

Wong RH et al. • Nutrients (2014)

“Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits.”

Key Findings:

Baseline clinic BP in 37 overweight middle-aged men and women who completed the trial averaged 145/84 mmHg.
There was no significant effect of treatment on ABP or any other outcome measure.
The failure to confirm prior evidence of the antihypertensive benefits of these extracts emphasises the importance of placebo control and the value of ABP monitoring.
Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits.

View all 40+ studies

What would you like to do next?

Compare with Others Find Based on Your Goals

Related Supplements

Age9.0

Aged Garlic Extract

9/10

Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.

Gse7.5

Grape Seed Extract

7.5/10

Rich source of oligomeric proanthocyanidins (OPCs) that support circulation, skin health, and antioxidant defense.

Bs8.5

Beta-Sitosterol

8.5/10

Plant sterol that reduces BPH urinary symptoms in clinical trials and blocks intestinal cholesterol absorption.

Qrc8.0

Quercetin

8/10

Flavonoid with senolytic and anti-inflammatory properties — supports immune defense, allergy relief, and exercise performance.