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Oxy4.0
Oxytocin Research
Too few graded studies
1,021 peer-reviewed studies
Showing the 997 most recent of 1021 studies.
All 1024 database studies by type: RCT 880 · Meta-Analysis 85 · Systematic Review 50 · Review 7 · Case Study 1 · other 1
What the evidence says
Too few graded studies
Oxytocin doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1985–2026.
Based on 991 studies · 82 meta-analyses · 852 RCTs
Confidence
High confidence
By outcome
Labor, postpartum & lactation
Too few graded studies203 studies
Social cognition & behaviour
Too few graded studies113 studies
Mood, anxiety & psychiatricStudied for social bonding and mood via oxytocin-receptor agonism in the CNS; human RCT evidence is largely null and fluid/sodium effects apply. · Not established
Too few graded studies59 studies
Safety & adverse effects
Too few graded studies8 studies
Steady research
245 studies in the last 5 years · Latest meta-analysis: 2026
198520052026
1Meta-Analysis2026
In plain English: However, trial methods seldom aligned with optimal protocols.
Bonnieux J, Gumuchian ST, Harboun A, Trespalacios F, Bélisle KA, Haddad A, Quintus-Bosz O, McLellan A, Chester-Trudel L, Garred D, Resendes T, Hazel L, Wong SF, Ellenbogen MA. · Neuroscience and biobehavioral reviews (2026)
Random effects meta-analysis of the pooled sample (N = 1922) revealed a small, non-significant overall treatment effect with substantial between-trial heterogeneity (g = 0.17, 95% CI [-0.05, 0.38], I² = 77.4%).
Removing two outlier studies with very large treatment effects in substance use disorders reduced the pooled estimate and eliminated heterogeneity (g = 0.05, 95% CI [-0.03, 0.12], I² = 0.0%).
Analyzing mental disorder subgroups separately revealed a small, significant effect in schizophrenia spectrum disorders (g = 0.12, 95% CI [0.01, 0.23]).