1Meta-Analysis2014
Cardoso C, Kingdon D, Ellenbogen MA · Psychoneuroendocrinology (2014)
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990 peer-reviewed studies
What the evidence says
Most Oxytocin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1972–2026 with a typical study size of 445 participants.
Based on 986 studies · 78 meta-analyses · 861 RCTs · 445 total participants
Confidence
High confidenceBy outcome
214 studies in the last 5 years · Latest meta-analysis: 2026
Cardoso C, Kingdon D, Ellenbogen MA · Psychoneuroendocrinology (2014)
Bakker JJ, Janssen PF, van Halem K, van der Goes BY, Papatsonis DN, van der Post JA · Cochrane Database Syst Rev (2013)
Phung LC, Farrington EK, Connolly M, Wilson AN, Carvalho B, Homer CSE · Am J Obstet Gynecol (2021)
Heringa SM, Begemann MJ, Goverde AJ, Sommer IE · Schizophr Res (2015)
Ooi YP, Weng SJ, Kossowsky J, Gerger H, Sung M · Pharmacopsychiatry (2017)
Lopes S, Osório FL · Horm Behav (2023)
Kumar N, Jahanfar S, Haas DM, Weeks AD · Cochrane Database Syst Rev (2021)
Salati JA, Leathersich SJ, Williams MJ, Cuthbert A, Tolosa JE · Cochrane Database Syst Rev (2019)
Sothornwit J, Ngamjarus C, Pattanittum P, Waidee T, Jampathong N, Jongjakapun A · Cochrane Database Syst Rev (2024)
Budden A, Chen LJ, Henry A · Cochrane Database Syst Rev (2014)
Nicolì P, Gulersen M, Beacham J, Hochler H, Familiari A, Locatelli A · Am J Obstet Gynecol MFM (2026)
Soltani H, Hutchon DR, Poulose TA · Cochrane Database Syst Rev (2010)
Pergialiotis V, Frountzas M, Prodromidou A, Prapa S, Perrea DN, Vlachos GD · Arch Gynecol Obstet (2016)
Yang X, Wang W, Wang XT, Wang YW · Neurosci Biobehav Rev (2021)
Huang Y, Huang X, Ebstein RP, Yu R · Neurosci Biobehav Rev (2021)
Wu Y, Wang H, Wu QY, Liang XL, Wang J · Arch Gynecol Obstet (2020)
Abd El Aziz MA, Iraqi A, Abedi P, Jahanfar S · Syst Rev (2018)
Keech B, Crowe S, Hocking DR · Psychoneuroendocrinology (2018)
Logue TC, Zullo F, van Biema F, Son M, London L, Paranandi S · Am J Obstet Gynecol MFM (2025)
Leppanen J, Ng KW, Kim YR, Tchanturia K, Treasure J · J Affect Disord (2018)