Pgn9.0

Panax Ginseng Research

44 peer-reviewed studies · Evidence score: 9/10

Oral Chinese herbal medicine combined with pharmacotherapy for stable COPD: a systematic review of effect on BODE index and six minute walk test

Chen X et al. • PloS one (2014)

These issues should be addressed in future trials.

The main meta-analysis results showed relative benefits for BODE Index in nine studies (mean difference [MD] -0.71, 95% confidence interval [CI] -0.94, -0.47) and 6MWT/D in 17 studies (MD 54.61 meters, 95%CI 33.30, 75.92) in favour of the CHM plus RP groups.
Detailed sub-group and sensitivity analyses were conducted.
Clinically meaningful benefits for BODE Index and 6MWT were found in multiple studies.

Systematic Reviewn=1,834

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Integrative Medicine for Relief of Nausea and Vomiting in the Treatment of Colorectal Cancer Using Oxaliplatin-Based Chemotherapy: A Systematic Review and Meta-Analysis

Chen MH et al. • Phytotherapy research : PTR (2016)

The oxaliplatin plus TM groups showed significantly reduced CINV (risk ratio 0.65 [0.59, 0.71], I(2) = 28%) compared with oxaliplatin controls, with or without the addition of conventional anti-eme...

The oxaliplatin plus TM groups showed significantly reduced CINV (risk ratio 0.65 [0.59, 0.71], I(2) = 28%) compared with oxaliplatin controls, with or without the addition of conventional anti-emetics.
These plants warrant further clinical research as potential additions to chemotherapy regimens in patients whose CINV is not sufficiently well controlled by conventional therapies.

Meta-Analysisn=1,843

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Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis

Sha'ari N et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2021)

Preliminary evidence suggests that Tribulus terrestris and Panax ginseng may be effective as alternative treatments for FSD in a clinical setting.

Panax ginseng was found to be effective in treating sexual arousal (SMD = 0.54, 95% CI = 0.11 - 0.97, p = 0.014) and sexual desire (SMD = 0.59, 95% CI = 0.27 - 0.90, p < 0.001) compared to placebo.
Preliminary evidence suggests that Tribulus terrestris and Panax ginseng may be effective as alternative treatments for FSD in a clinical setting.
Further research warranted to confirm findings

Meta-Analysisn=536

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A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs

Petersen MJ et al. • Phytotherapy research : PTR (2021)

Combinations between chronic cannabis use and selective serotonin reuptake inhibitors or non-steroidal antiinflammatory drugs should be carefully monitored, whereas no significant evidence for drug-interactions between conventional MS-drugs and ginger, cranberry, vitamin D, fatty acids, turmeric, probiotics or glucosamine was found.

A total of 129 published papers found via PubMed and Web of Science were reviewed according to defined inclusion- and exclusion criteria.
Findings suggested that daily recommended doses of Panax ginseng and Ginkgo biloba should not be exceeded, and herbal preparations differing from standardized products should be avoided, especially when combined with anticoagulants or substrates of certain cytochrome P450 isoforms.
Further studies are required regarding ginseng's ability to increase aspirin bioavailability.

Systematic Reviewn=129

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Targeting pyroptosis: A novel strategy of ginseng for the treatment of diabetes and its chronic complications

Li K et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)

In summary, this review elucidates the happening mechanisms of pyroptosis in diabetes and associated chronic complications, and summarizes published studies about ginseng and its active ingredients in improving diabetes by regulating pyroptosis-related pathways.

In summary, this review elucidates the happening mechanisms of pyroptosis in diabetes and associated chronic complications, and summarizes published studies about ginseng and its active ingredients in improving diabetes by regulating pyroptosis-related pathways.
However, almost all researches are limited to animal and cell experiments, and more clinical trials are required to prove the therapeutic effect of ginseng on diabetes by targeting pyroptosis.
Further research warranted to confirm findings

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Systematic review and pharmacological insights of ginsenoside Rf: Current status and future perspectives

Li P et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)

This mini-review also delves into the pharmacokinetics of Rf and the potential for future studies, intending to offer a comprehensive insight into Rf and its possible application in medical and pharmacological domains.

Systematic review examining Panax Ginseng efficacy
Further research warranted to confirm findings

Systematic Review

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Comprehensive PRISMA Based Systematic Review: Exploring the Phytochemistry, Pharmacological Profile and Clinical aspects of Panax ginseng

Singh S et al. • Current topics in medicinal chemistry (2025)

This manuscript comprehensively explores the versatile therapeutic applications of ginseng in the treatment of various types of cancers.

This manuscript comprehensively explores the versatile therapeutic applications of ginseng in the treatment of various types of cancers.
Further research warranted to confirm findings

Systematic Review

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Dietary Saponins as Antiaging Agents: A Systematic Review of Molecular Mechanisms, Nutritional Intervention, and Product Development

Guo C et al. • Journal of agricultural and food chemistry (2025)

Future antiaging research on dietary saponins should prioritize high-purity monomers, optimize their bioactive structure, and yield via synthetic biology and nanoencapsulation, followed by clinical validation of efficacy.

Moreover, some antiaging products based on dietary saponins have been developed and utilized as functional foods or nutritional supplements to achieve antiaging in human wellness.
This review systematically reviews antiaging mechanisms of dietary saponins, including their structure-activity relationship, from fundamental research to the development of associated products.
Future antiaging research on dietary saponins should prioritize high-purity monomers, optimize their bioactive structure, and yield via synthetic biology and nanoencapsulation, followed by clinical validation of efficacy.

Systematic Review

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Efficacy of Panax ginseng on fatigue: A systematic review and meta-analysis

Arring NM et al. • Journal of Alternative and Complementary Medicine (2018)

Panax ginseng showed anti-fatigue effects compared to placebo.

Significant reduction in fatigue scores
Benefits seen in fatigued populations
Effects build over weeks of use

Meta-Analysisn=534

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Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use

Petre GC et al. • Nutrients (2023)

DSs marketed in Italy are usually blends of many substances that are frequently employed at a negligible dose or without any evidence.

Based on the scoring system, 2 (8%) supplements matched with the cluster of higher expected efficacy, 3 (12%) with the lower efficacy cluster and 20 (80%) matched with the criterion of no expected efficacy.
A systematic review of the literature was performed to evaluate the effect of DS and to detect the active ingredients able to improve erectile function-called effective ingredients (EIs)-and their minimal effective daily dose (mED).
A metanalysis identified some nutraceuticals, such as Panax ginseng, Tribulus terrestris and L-arginine, that are able to improve male sexual function.

Meta-Analysis

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The Effect of Ginseng Supplementation on Lipid Profile: GRADE-assessed Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials

Arabi SM et al. • Current pharmaceutical design (2024)

Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions.

The Weighted Mean Differences (WMD) and 95% Confidence Intervals (CI) for TG, TC, LDL-C, and HDL-C did not show significant changes with ginseng supplementation.
Taking into account the results, using ginseng did not have a statistically significant influence on lipid profile parameters in individuals with different health conditions.
Further, well-designed RCTs focusing on specific diseases are needed to clarify the potential beneficial effects of ginseng and its derivatives on lipid profile.

Meta-Analysisn=29

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The effect of Panax ginseng supplementation on markers of resistance exercise-induced muscle damage: a systematic review

Morgans R et al. • The Journal of sports medicine and physical fitness (2024)

From 180, six studies were included in the systematic review.

From 180, six studies were included in the systematic review.
The main findings suggest that Panax ginseng does not attenuate markers of EIMD following resistance training.
However, research is still preliminary.

Systematic Review

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A comprehensive and systemic review of ginseng-based nanomaterials: Synthesis, targeted delivery, and biomedical applications

Balusamy SR et al. • Medicinal research reviews (2023)

Medicinal Research Reviews

In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications.
Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites.
Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.

Systematic Review

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Compound K: A systematic review of its anticancer properties and probable mechanisms

Tam DNH et al. • Fundamental & clinical pharmacology (2023)

The safety and further clinical trials of CK should be explored for future drug development.

The purity of CK in our included studies was at least 95%.
The in vivo studies reported a significant decrease in tumor volume in mice treated with CK.
The in vitro studies reported that CK had a potential anticancer activity on several cell lines including human lung cancer cell lines (A549, PC-9), nasopharyngeal carcinoma cell line (Hk-1), liver cancer cell line (BEL 7402), and pediatric acute myeloid leukemia cell lines (Kasumi-1, MV4-11).

Systematic Review

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Panax ginseng clinical trials: Current status and future perspectives

Fan S et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2020)

This review could assist the basic researchers and clinical doctors to understand current status and problem of ginseng clinical research, and perhaps could benefit for the reasonable and accurate ...

This review could assist the basic researchers and clinical doctors to understand current status and problem of ginseng clinical research, and perhaps could benefit for the reasonable and accurate design of future clinical studies.

Systematic Reviewn=200

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Plant Adaptogens-History and Future Perspectives

Todorova V et al. • Nutrients (2021)

In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body's resistance to stress and to improve physical endurance.
Although now many people take plant adaptogens, the clinical trials on human are limited.
The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection.

Meta-Analysis

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Exploratory Systematic Review and Meta-Analysis of Panax Genus Plant Ingestion Evaluation in Exercise Endurance

Ikeuchi S et al. • Nutrients (2022)

This systematic review suggests that the ingestion of PGPs or ginsenosides, especially Rg1, is effective in improving exercise endurance in healthy adults.

We found that ingestion of PGPs or ginsenosides significantly improved exercise endurance (SMD [95% CI]: 0.58 [0.22-0.95], I2 = 0%).
It was suggested that ginsenoside Rg1 (Rg1) and PGPs extract containing Rg1 were significantly effective in improving exercise endurance (SMD [95% CI]: 0.70 [0.14-1.27], I2 = 30%) by additional analysis.
This systematic review suggests that the ingestion of PGPs or ginsenosides, especially Rg1, is effective in improving exercise endurance in healthy adults.

Meta-Analysis

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Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Pferschy-Wenzig EM et al. • Nutrients (2022)

Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways.

Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways.
However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites.
Data for Panax ginseng, Schisandra chinensis, and Salvia rosmarinus indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits.

Systematic Review

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Panax ginseng and aging related disorders: A systematic review

de Oliveira Zanuso B et al. • Experimental gerontology (2022)

The use of this plant in cancer resulted in improved quality of life and mood.

The use of this plant in cancer resulted in improved quality of life and mood.
It decreased symptoms of fatigue, nausea, vomiting, and dyspnea, reducing anxiety.
Panax ginseng has been shown to exert potent therapeutic benefits that can act as a complementary treatment in managing patients with chronic diseases related to aging.

Systematic Review

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Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng

Lee NH et al. • Journal of acupuncture and meridian studies (2011)

However, ginseng generally has a good safety profile and the incidence of adverse effects seems to be low.

However, ginseng generally has a good safety profile and the incidence of adverse effects seems to be low.
In conclusion, our review compiles the evidence on the use of ginseng, finding a strong positive potential for glucose metabolism, psychomotor function, and pulmonary disease, but not for physical performance enhancement.

Systematic Reviewn=57

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