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Pel6.5

Pelargonium Sidoides Research

Mostly mechanism / observational

30 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Pelargonium Sidoides studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 2003–2026 with a typical study size of 220 participants.

Based on 30 studies · 2 meta-analyses · 21 RCTs

Confidence

High confidence

By outcome

Immune supportShorter duration and reduced severity of acute bronchitis and upper-respiratory infection symptoms (liquid EPs 7630) · Within days of starting an acute infection
Mostly mechanism / observational5 studies
Safety profile
Too few graded studies1 study

Active research area

9 studies in the last 5 years · Latest meta-analysis: 2013

200320142026

1Meta-Analysis2008

Agbabiaka TB, Guo R, Ernst E · Phytomedicine (2008)

Pelargonium Sidoides Research

Mostly mechanism / observational

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis.

Pelargonium sidoides extract for treating acute respiratory tract infections.

An evidence-based systematic review of umckaloabo (Pelargonium sidoides) by the Natural Standard Research Collaboration.

Treatment of acute bronchitis in adults with a pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial.

Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial.

[Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment].

Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides.

Efficacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial.

The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy.

Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots.

Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study.

Effectiveness of Pelargonium sidoides in pediatric patients diagnosed with uncomplicated upper respiratory tract infection: a single-blind, randomized, placebo-controlled study.

Pelargonium sidoides root extract for the treatment of acute cough due to lower respiratory tract infection in adults: a feasibility double-blind, placebo-controlled randomised trial.

Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study with 124 patients.

Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality-of-life and other patient-reported outcomes in adults receiving add-on therapy.

Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial.

Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children?

Efficacy and Tolerability of High-dose Pelargonium Extract in Patients With the Common Cold.

African geranium (EPs 7630), part I: a proprietary root extract of Pelargonium sidoides (EPs 7630) is found to be effective in resolving symptoms associated with the common cold in adults.

Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of athletes after exhaustive exercise: modulation of secretory IgA, IL-6 and IL-15.