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Pnl1.5

Pinealon Research

Mostly mechanism / observational

7 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Pinealon studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from mixed-quality studies published 2012–2024.

Based on 7 studies

Confidence

Low confidence

By outcome

Neuroprotection & brain agingA short peptide with neuroprotective signals in cells and animals under hypoxic/oxidative stress; evidence is thin, low-quality, and from a single group, with mixed (incl. prooxidant) findings. · Not established (no robust human data)
Mostly mechanism / observational3 studies
Longevity & agingPromoted for 'biological age' improvement on the basis of weak human reports and proposed epigenetic gene regulation; long-term human safety largely unknown. · Not established
Mostly mechanism / observational3 studies
Cognitive function
Too few graded studies2 studies

Steady research

1 study in the last 5 years

201220182024

1In Vitro2014

In plain English: Peptides Glu-Asp-Arg and Lys-Glu-Asp stimulate serotonin expression in aging cultures of brain cortex cells.

Khavinson VKh, Lin'kova NS, Tarnovskaya SI, Umnov RS, Elashkina EV, Durnova AO. · Bull Exp Biol Med (2014)

In-vitro study reporting that Glu-Asp-Arg (EDR) stimulates serotonin expression in aging brain-cortex cell cultures
Used molecular docking to propose EDR regulates the 5-tryptophan-hydroxylase gene (the enzyme in serotonin synthesis)
Identified a complementary CCTGCC nucleotide sequence as the proposed binding target

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2Review2020

In plain English: The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective properties.

Khavinson V, Linkova N, Kozhevnikova E, Trofimova S. · Molecules (2020)

Review from the originating group laying out the proposed mechanism of the EDR (Glu-Asp-Arg) peptide in neuroprotection
Proposes EDR enters cells and binds histones/RNA, altering the MAPK/ERK pathway and synthesis of proapoptotic (caspase-3, p53) and antioxidant (SOD2, GPX1) proteins
States EDR interferes with dendritic-spine elimination in Alzheimer's/Huntington's neuronal cultures and 'improves memory issues in elderly patients'

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3In Vitro2024

In plain English: EDR peptide reduces oxidative DNA damage in induced neurons derived from elderly donor fibroblasts.

Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D, Krasichkov A, Khotin M, Ryzhak G. · Int J Mol Sci (2024)

In-vitro human-cell model: aged dermal fibroblasts from elderly donors transdifferentiated into induced cortical neurons
EDR (Glu-Asp-Arg) and related peptides promoted arborisation of the dendritic tree, increasing the number and total length of dendrites
EDR specifically reduced oxidative DNA damage in induced neurons from elderly donors

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4Open-Label2012

In plain English: Workers of locomotive brigades used preparation during two weeks (1 capsule containing 100 mkg of Pinealon 2 times a day). Pinealon application has improved parameters of biological age and indicators determining the effectiveness of adaptive reactions.

Nazimko VA, Morgul' EV, Petrova OA, Sheĭkhova RG, Kozina LS, Savenko MA, Lysenko DS. · Adv Gerontol (2012)

Small, open, uncontrolled human report in locomotive-brigade workers exposed to occupational stress
Used oral Pinealon capsules of 100 mcg twice daily for two weeks — the source of the only published human dosing reference
Claimed improved biological-age parameters and adaptive-reaction indicators

5Open-Label2015

In plain English: The preparations of "Pinealon" and "Vesugen" have had the significant anabolic effect.

Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva IuE. · Adv Gerontol (2015)

Small human study (32 people, aged 41-83) with polymorbidity and organic brain syndrome in remission, using Pinealon and Vesugen
Reported anabolic effects and slowed biological-age indicators, with Vesugen showing a more visible effect than Pinealon
Crucially also found prooxidant activity by chemiluminescence and a significant decrease in CD34+ haematopoietic markers — flagged as needing future study

6Animal2014

In plain English: in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level.

Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA, Dem'ianenko SV. · Adv Gerontol (2014)

Animal study: aged rats under acute hypoxic hypoxia, examining caspase-3 activity in brain and IL-6 / TNF in serum
Pinealon (Glu-Asp-Arg) was associated with increased neurogenesis and a decrease in neuroinflammatory reactions toward reference levels under brain hypoxia
Compared against Cortexin, which reduced programmed cell death but kept IL-6 elevated

7Open-Label2016

In plain English: The most pronounced positive impact on indicators of biological age were detected during the combined use of these two Oligopeptide complexes.

Myakotnykh VS, Torgashov MN, Egorin KV, Meshchaninov VN, Gavrilov VI, Borovkova TA, Zvezdina EM, Verzhbitskaya TY, Tkachenko EL. · Adv Gerontol (2016)

Human study of 110 people across age groups comparing several geroprotective methods, including the oligopeptides Vezugen and Pinealon (Glu-Asp-Arg)
The combined use of the two peptides gave the most pronounced positive impact on biological-age indicators
The oligopeptide preparations were rated among the safest of the methods compared on biochemical, immunological, and clinical parameters

View in Research Library

Pinealon Research

Mostly mechanism / observational

Short peptides stimulate serotonin expression in cells of brain cortex.

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.

Analysis of some parameters of biological age and adaptation possibilities of workers of locomotive brigades.

Effect of synthetic peptides on aging of patients with chronic polymorbidity and organic brain syndrome of the central nervous system in remission.

Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon.

Comparative analysis of different methods of geroprotective.