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4 peer-reviewed studies
What the evidence says
Most Polypodium Leucotomos studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2014–2023 with a typical study size of 131 participants.
Based on 4 studies · 2 RCTs · 171 total participants
Confidence
LowBy outcome
1 study in the last 5 years
A multicenter randomized trial (n=131) found oral Polypodium leucotomos plus topical sunscreen improved photoprotection versus sunscreen alone.
Pellacani G et al. · Photodermatol Photoimmunol Photomed (2023)
A double-blind, placebo-controlled trial (n=40) found oral Polypodium leucotomos accelerated melasma improvement alongside hydroquinone and SPF50 sunscreen.
Goh CL et al. · J Clin Aesthet Dermatol (2018)
A status report reviewed the clinical efficacy of Polypodium leucotomos extract for photoprotection and pigmentary disorders.
Winkelmann RR et al. · J Drugs Dermatol (2015)
A review covered Polypodium leucotomos as an adjunct for pigmentary disorders.
Nestor M et al. · J Clin Aesthet Dermatol (2014)