1RCT2006
Reyes E, Jaén P, de las Heras E, Carrión F, Alvarez-Mon M, de Eusebio E · J Dermatol Sci (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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19 peer-reviewed studies
What the evidence says
Polypodium Leucotomos doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality randomised trials published 2006–2026 with a typical study size of 40 participants.
Based on 19 studies · 13 RCTs · 40 total participants
Confidence
Moderate confidenceBy outcome
9 studies in the last 5 years
Reyes E, Jaén P, de las Heras E, Carrión F, Alvarez-Mon M, de Eusebio E · J Dermatol Sci (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Pacifico A, Damiani G, Iacovelli P, Conic RRZ, Gonzalez S, Morrone A · Dermatol Ther (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Pellacani G, Peris K, Ciardo S, Pezzini C, Tambone S, Farnetani F · Photodermatol Photoimmunol Photomed (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Emanuele E, Bertona M, Biagi M · Neuro Endocrinol Lett (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Auriemma M, Di Nicola M, Gonzalez S, Piaserico S, Capo A, Amerio P · Dermatol Surg (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ahmed AM, Lopez I, Perese F, Vasquez R, Hynan LS, Chong B · JAMA Dermatol (2013)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Villa A, Viera MH, Amini S, Huo R, Perez O, Ruiz P · J Am Acad Dermatol (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ramírez-Bosca A, Zapater P, Betlloch I, Albero F, Martínez A, Díaz-Alperi J · Actas Dermosifiliogr (2012)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Miola AC, Miot HA · An Bras Dermatol (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Middelkamp-Hup MA, Bos JD, Rius-Diaz F, Gonzalez S, Westerhof W · J Eur Acad Dermatol Venereol (2007)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: These findings suggest that supplementation with PLE, ROE, and vitamins A, C, D, and E provides systemic photoprotection by enhancing UV tolerance and reducing erythema without affecting tanning response.
Keršmanc P, Pogačnik T, Žmitek J, Hristov H, Točkova O, Žmitek K. · Nutrients (2025)
In plain English: The review confirms the efficacy of polyphenols in preventing and treating AKs and related skin conditions.
Rodríguez-Luna A, Zamarrón A, Longo C, Pellacani G, Peris K, Calzavara-Pinton P, de Galvez MV, Gilaberte Y, de Troya M, Juarranz Á, González S. · Actas dermo-sifiliograficas (2025)
In plain English: UVA-induced erythema was significantly reduced by PL and NAM, but neither had measurable effects on TT-dimer induction.
Faisal A, Lerche CM, Douki T, Philipsen PA, Pihl C, Gregersen T, Granborg JR, Bjerring P, Haedersdal M, Wiegell SR. · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2026)
In plain English: Comprehensive, behaviour-based photoprotection programmes are essential for high-risk groups.
Gilaberte Y, Ederra-Galé A, García-Alfonso JJ, Gracia-Cazaña T. · Cancers (2026)
In plain English: PLE exhibits strong therapeutic potential with an encouraging safety profile.
Zundell MP, Katz A, Shah M, Burshtein J, Rigel D, Zakria D. · Journal of drugs in dermatology : JDD (2025)
In plain English: The oral PLE aqueous extract product appears to be a safe and effective adjunctive treatment for melasma in combination with topical hydroquinone and sunscreen.
Goh CL et al. · J Clin Aesthet Dermatol (2018)
In plain English: This review concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.
Winkelmann RR et al. · J Drugs Dermatol (2015)
In plain English: Orally administered Polypodium leucotomos also appears to provide adjunctive benefits in treating vitiligo, melasma, and may have the potential to help with postinflammatory hyperpigmentation.
Nestor M et al. · J Clin Aesthet Dermatol (2014)
In plain English: A systematic review of oral photoprotective supplements supported Polypodium leucotomos for modest photoprotection.
Natarelli, Aflatooni, Stankiewicz, Correa-Selm, Sivamani · Journal of medicinal food (2025)