1RCT2006
Reyes E, Jaén P, de las Heras E, Carrión F, Alvarez-Mon M, de Eusebio E · J Dermatol Sci (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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19 peer-reviewed studies
What the evidence says
Most Polypodium Leucotomos studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2006–2026 with a typical study size of 40 participants.
Based on 19 studies · 13 RCTs · 312 total participants
Confidence
Moderate confidenceBy outcome
9 studies in the last 5 years
Reyes E, Jaén P, de las Heras E, Carrión F, Alvarez-Mon M, de Eusebio E · J Dermatol Sci (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Pacifico A, Damiani G, Iacovelli P, Conic RRZ, Gonzalez S, Morrone A · Dermatol Ther (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Pellacani G, Peris K, Ciardo S, Pezzini C, Tambone S, Farnetani F · Photodermatol Photoimmunol Photomed (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Emanuele E, Bertona M, Biagi M · Neuro Endocrinol Lett (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Auriemma M, Di Nicola M, Gonzalez S, Piaserico S, Capo A, Amerio P · Dermatol Surg (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ahmed AM, Lopez I, Perese F, Vasquez R, Hynan LS, Chong B · JAMA Dermatol (2013)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Villa A, Viera MH, Amini S, Huo R, Perez O, Ruiz P · J Am Acad Dermatol (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ramírez-Bosca A, Zapater P, Betlloch I, Albero F, Martínez A, Díaz-Alperi J · Actas Dermosifiliogr (2012)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Miola AC, Miot HA · An Bras Dermatol (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Middelkamp-Hup MA, Bos JD, Rius-Diaz F, Gonzalez S, Westerhof W · J Eur Acad Dermatol Venereol (2007)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: This study supports oral supplementation as an adjunct to topical photoprotection, with prolonged use potentially yielding cumulative benefits.
Keršmanc P, Pogačnik T, Žmitek J, Hristov H, Točkova O, Žmitek K. · Nutrients (2025)
In plain English: Future clinical trials should focus on diverse populations at higher risk of skin cancer and explore new ingredients as well as combinations of various ingredients to optimize therapeutic applications.
Rodríguez-Luna A, Zamarrón A, Longo C, Pellacani G, Peris K, Calzavara-Pinton P, de Galvez MV, Gilaberte Y, de Troya M, Juarranz Á, González S. · Actas dermo-sifiliograficas (2025)
In plain English: Further research should investigate the relation between these findings and the chemopreventive effect of NAM and PL on skin cancer.
Faisal A, Lerche CM, Douki T, Philipsen PA, Pihl C, Gregersen T, Granborg JR, Bjerring P, Haedersdal M, Wiegell SR. · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2026)
In plain English: Comprehensive, behaviour-based photoprotection programmes are essential for high-risk groups.
Gilaberte Y, Ederra-Galé A, García-Alfonso JJ, Gracia-Cazaña T. · Cancers (2026)
In plain English: J Drugs Dermatol. 2025;24(4):346-351. doi:10.36849/JDD.8410R1.
Zundell MP, Katz A, Shah M, Burshtein J, Rigel D, Zakria D. · Journal of drugs in dermatology : JDD (2025)
In plain English: The oral PLE aqueous extract product appears to be a safe and effective adjunctive treatment for melasma in combination with topical hydroquinone and sunscreen.
Goh CL et al. · J Clin Aesthet Dermatol (2018)
In plain English: This review concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.
Winkelmann RR et al. · J Drugs Dermatol (2015)
In plain English: Orally administered Polypodium leucotomos also appears to provide adjunctive benefits in treating vitiligo, melasma, and may have the potential to help with postinflammatory hyperpigmentation.
Nestor M et al. · J Clin Aesthet Dermatol (2014)
In plain English: A systematic review of oral photoprotective supplements supported Polypodium leucotomos for modest photoprotection.
Natarelli, Aflatooni, Stankiewicz, Correa-Selm, Sivamani · Journal of medicinal food (2025)