57 peer-reviewed studies · Evidence score: 9/10
Rossignol P et al. • Lancet (London, England) (2025)
In patients with kidney failure on haemodialysis and with high risk of adverse cardiovascular outcomes, spironolactone did not reduce the incidence of major cardiovascular events.
Rokkas T et al. • The American journal of gastroenterology (2025)
The comparative effectiveness ranking showed that P-CAB dual therapy regimen ranked first for efficacy and last for adverse effects and had the best profile for integrated efficacy-safety.
Pillinger T et al. • Lancet (London, England) (2025)
We found strong evidence that antidepressants differ markedly in their physiological effects, particularly for cardiometabolic parameters.
Filippini T et al. • Clinical Kidney Journal (2024)
Boosting potassium intake can play a critical role in improving BP control and lowering cardiovascular risk.
Kanu JE et al. • World journal of gastroenterology (2024)
VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen.
Amer BE et al. • Pediatric nephrology (Berlin, Germany) (2024)
Isotonic IV-MFT was superior to the hypotonic one in reducing the risk of iatrogenic hyponatremia in hospitalized children.
Zou S et al. • Pharmacotherapy (2024)
This is the first study to compare the effect of ASDs on inhibiting nocturnal acid breakthrough.
Gan L et al. • BMC medicine (2024)
Our study demonstrates significant positive associations between daily sodium intake (within the range of sodium intake between 2,000 and 7,500 mg/d), the sodium-potassium ratio, and risk of CVD and overall mortality, with women having stronger sodium-potassium ratio-mortality associations than men, and with the meta-analysis providing compelling support for the CVD associations.
Chao YC et al. • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (2023)
Ingenol mebutate, cryotherapy, podophyllotoxin, and KOH were more effective than the other interventions in achieving complete clearance, but safety concerns regarding ingenol mebutate have recently been reported.
Carvalho PEP et al. • Clinical research in cardiology : official journal of the German Cardiac Society (2023)
The use of new potassium binders Patiromer or SZC in patients with HF at risk for hyperkalemia increased the rates of medical therapy optimization with renin-angiotensin-aldosterone inhibitors and reduced the incidence of hyperkalemia, at the cost of an increased prevalence of hypokalemia.
Martins VM et al. • Journal of hypertension (2023)
Thiazides with potassium-sparing diuretics are associated with increased BP-lowering efficacy compared with thiazides alone while minimizing hypokalaemia and hyperglycaemia.
Simadibrata DM et al. • Journal of gastroenterology and hepatology (2022)
Vonoprazan is superior to PPI in first-line H. pylori eradication and erosive esophagitis but non-inferior in other gastric acid-related diseases.
Filippini T et al. • Journal of the American Heart Association (2020)
U-shaped relationship between potassium excretion and BP levels observed.
Aburto NJ et al. • BMJ (2013)
Increased potassium intake significantly reduces blood pressure and stroke risk.
Jessen MK et al. • Resuscitation (2025)
Evidence supports treatment with insulin in combination with glucose, inhaled or intravenous sal-butamol, or the combination.
Poorolajal J et al. • PLOS ONE (2017)
Potassium supplementation decreased systolic BP by 4.48 mmHg and diastolic by 2.96 mmHg.
Natale P et al. • The Cochrane database of systematic reviews (2020)
Evidence supporting clinical decision-making for different potassium binders to treat chronic hyperkalaemia in adults with CKD is of low certainty; no studies were identified in children.
Fu J et al. • Journal of the American Heart Association (2020)
Aerobic exercise, isometric training, low-sodium and high-potassium salt, comprehensive lifestyle modification, salt restriction, breathing-control, meditation and low-calorie diet also have obvious effects on BP reduction.
Moore RA et al. • The Cochrane database of systematic reviews (2015)
There is a body of reliable evidence about the efficacy of some of the most commonly available drugs and doses widely available without prescription.
Reddin C et al. • European journal of nutrition (2023)
Global mean potassium intake (2.25 g/day) falls below current guideline recommended intake level of > 3.5 g/day, with only 14% (95% CI 11-17%) of the global population achieving guideline-target mean intake.