1Meta-Analysis2015
Domecq JP, Prutsky G, Leppin A, Sonbol MB, Altayar O, Undavalli C · J Clin Endocrinol Metab (2015)
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68 peer-reviewed studies
What the evidence says
Most Pramlintide studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1997–2023.
Based on 68 studies · 5 meta-analyses · 61 RCTs
Confidence
High confidenceBy outcome
Only 4 studies in the last 5 years · Latest meta-analysis: 2021
Domecq JP, Prutsky G, Leppin A, Sonbol MB, Altayar O, Undavalli C · J Clin Endocrinol Metab (2015)
Singh-Franco D, Perez A, Harrington C · Diabetes Obes Metab (2011)
Avgerinos I, Manolopoulos A, Michailidis T, Kitsios K, Liakos A, Karagiannis T · Diabetes Obes Metab (2021)
Hollander P, Ratner R, Fineman M, Strobel S, Shen L, Maggs D · Diabetes Obes Metab (2003)
Giorda CB, Nada E, Tartaglino B, Marafetti L, Gnavi R · Diabetes Obes Metab (2014)
Riddle M, Frias J, Zhang B, Maier H, Brown C, Lutz K · Diabetes Care (2007)
Heise T, Heinemann L, Heller S, Weyer C, Wang Y, Strobel S · Metabolism (2004)
Chapman I, Parker B, Doran S, Feinle-Bisset C, Wishart J, Lush CW · Obesity (Silver Spring) (2007)
Wysham C, Lush C, Zhang B, Maier H, Wilhelm K · Curr Med Res Opin (2008)
Levetan C, Want LL, Weyer C, Strobel SA, Crean J, Wang Y · Diabetes Care (2003)
Hinshaw L, Schiavon M, Dadlani V, Mallad A, Dalla Man C, Bharucha A · J Clin Endocrinol Metab (2016)
Chase HP, Lutz K, Pencek R, Zhang B, Porter L · J Pediatr (2009)
Thompson RG, Pearson L, Kolterman OG · Diabetologia (1997)
Maggs D, Shen L, Strobel S, Brown D, Kolterman O, Weyer C · Metabolism (2003)
Edelman SV, Darsow T, Frias JP · Int J Clin Pract (2006)
Chan JL, Koda J, Heilig JS, Cochran EK, Gorden P, Oral EA · Clin Endocrinol (Oxf) (2016)
Riddle MC, Nahra R, Han J, Castle J, Hanavan K, Hompesch M · Diabetes Care (2018)
Hollander PA, Levy P, Fineman MS, Maggs DG, Shen LZ, Strobel SA · Diabetes Care (2003)
Fineman M, Weyer C, Maggs DG, Strobel S, Kolterman OG · Horm Metab Res (2002)
Renukuntla VS, Ramchandani N, Trast J, Cantwell M, Heptulla RA · J Diabetes Sci Technol (2014)