61 peer-reviewed studies · Evidence score: 9/10
Asad A et al. • Nutrition reviews (2025)
Probiotics showed substantial reductions in depression symptoms and moderate reductions in anxiety symptoms.
Mendonça CD et al. • BMC oral health (2024)
This meta-analysis examined the effects of Probiotics.
Rahman MN et al. • Gut microbes (2024)
Protocol registration: PROSPERO (ID = CRD42021276045).
Liu Y et al. • Frontiers in Immunology (2023)
Meta-analysis of data from 26 RCTs indicated that probiotics significantly improved gut barrier function.
Goodoory VC et al. • Gastroenterology (2023)
Some combinations of probiotics or strains may be beneficial in IBS.
Xie Q et al. • Nutricion hospitalaria (2023)
Conclusion: the use of probiotics in patients with asthma can improve lung inflammation and asthma symptoms, reduce the number of asthma attacks, and have no effect on lung function.
Memon H et al. • Diabetes research and clinical practice (2023)
The addition of probiotics to metformin therapy is associated with improvement in T2DM outcomes.
Estevinho MM et al. • United European Gastroenterology Journal (2024)
Probiotics show promise in inflammatory bowel disease through multiple mechanisms including butyrate production and immune modulation.
Zhang L et al. • BMC geriatrics (2022)
We recommend that elderly individuals could be routinely distributed probiotics to prevent AAD development when receiving antibiotic treatment.
Liu YC et al. • International journal of molecular sciences (2022)
We recommend the use of probiotics to prevent and treat oral mucositis during cancer therapy.
Collinson S et al. • The Cochrane database of systematic reviews (2020)
Probiotics probably make little or no difference to the number of people who have diarrhoea lasting 48 hours or longer, and we are uncertain whether probiotics reduce the duration of diarrhoea.
Ong TG et al. • The Cochrane database of systematic reviews (2019)
There is no clear evidence that probiotics are more effective than placebo at preventing infantile colic; however, daily crying time appeared to reduce with probiotic use compared to placebo.
Goldenberg JZ et al. • The Cochrane database of systematic reviews (2017)
Based on this systematic review and meta-analysis of 31 randomized controlled trials including 8672 patients, moderate certainty evidence suggests that probiotics are effective for preventing CDAD (NNTB = 42 patients, 95% CI 32 to 58).
Hempel S et al. • JAMA (2012)
Probiotics significantly reduced the risk of antibiotic-associated diarrhea.
Soleimanpour S et al. • Journal of psychiatric research (2024)
Our study highlighted the significant improvement in ASD behavioral symptoms through probiotic supplementation.
Hao Q et al. • Cochrane Database of Systematic Reviews (2015)
Probiotics were better than placebo in reducing the number of participants experiencing acute URTIs.
Reis DJ et al. • Journal of Affective Disorders (2018)
Probiotic supplementation showed a small but significant effect on anxiety symptoms.
Wu Y et al. • Nutrients (2024)
However, the most effective probiotic combination or strain remains unclear, while prebiotics and synbiotics did not show significant improvement.
Wang Y et al. • JAMA pediatrics (2023)
In this systematic review and NMA, moderate- to high-certainty evidence demonstrated an association between multistrain probiotics and reduction in all-cause mortality; these interventions were also associated with the best effectiveness for other key outcomes.
Zagórska A et al. • Beneficial microbes (2020)
Among the parameters determining the success of the given treatment, the most significant were probiotic composition (multi-strain formulation), the quantity of ingested psychobiotics and the duration of the study.