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Pr5.5
Propolis – Forschung
Hilft wahrscheinlich
156 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Propolis scheint in 7 von 7 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1979–2026 mit einer typischen Studiengröße von 199 Teilnehmenden.
Basierend auf 156 Studien · 23 Meta-Analysen · 103 RCTs · 12,513 Teilnehmende insgesamt
Immune supportVerbesserte Immunfunktion und Infektionsresistenz · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung16 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung13 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung11 Studien
Wound & ulcer healing
Überwiegend Mechanismus / Beobachtung7 Studien
Liver health
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung3 Studien
Cold sores & HSV
Zu wenige bewertete Studien2 Studien
Depression & mood
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 28 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
13k
typische Studie: 199 Personen
Stärkste Designs
126
23 gepoolt, 103 randomisiert
Zeigte Nutzen
100%
7/7 Studien
Untersuchte Populationen
Adults2
COVID-19 patients2
Various conditions with inflammation1
Head and neck cancer patients1
Aktives Forschungsgebiet
107 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
197920022026
1Meta-Analysen=3,544 · very large study2025
Einfach gesagt: This meta-analysis examined the effects of Propolis.
Norouzzadeh M et al. · Nutrition & diabetes (2025)
Propolis demonstrated reductions in anthropometric measures and improvements in lipid profile, glycemic control, liver enzymes, and inflammation and oxidative stress markers.
While long-term or high-dose honey consumption in individuals with health concerns warrants caution, RJ and propolis demonstrated dose-dependent benefits for cardiometabolic health with proper certainty.
Future research should focus on population-specific characteristics and optimized dosages.
6Anti-inflammatory mechanismsSystematische Übersichtn=166 · medium study2022
Einfach gesagt: Propolis also reduces the migration of immune cells such as macrophages and neutrophils, possibly by downregulating the chemokines CXCL9 and CXCL10.
Zulhendri F et al. · Molecules (Basel, Switzerland) (2022)
Several key themes related to the anti-inflammatory properties of propolis were subsequently identified, namely in relation to cancers, oral health, metabolic syndrome, organ toxicity and inflammation, immune system, wound healing, and pathogenic infections.
Based on the latest experimental evidence, propolis is demonstrated to possess various mechanisms of action in modulating inflammation towards the regulatory balance and anti-inflammatory environment.
In general, we summarize that propolis acts as an anti-inflammatory substance by inhibiting and downregulating TLR4, MyD88, IRAK4, TRIF, NLRP inflammasomes, NF-κB, and their associated pro-inflammatory cytokines such as IL-1β, IL-6, IFN-γ, and TNF-α.
7Mucositis severity scoresMeta-Analysen=199 · medium study2022
Einfach gesagt: Though oral and topical antioxidants significantly improved mucositis severity scores in HNC patients receiving radiotherapy with/without chemotherapy in individual studies, the quality of the evidence was low due to the small number of studies and unclear/high-risk bias.
Raza A et al. · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2022)
Likely real
Included studies showed a statistically significant improvement in mucositis severity score for all antioxidants except melatonin.
Patients receiving vitamin E were 60% less likely to develop severe mucositis grade 2 or higher than those receiving placebo in one study (P = 0.040).
Patients receiving zinc were 95% less likely to develop severe mucositis (grades 3-4) in one study compared to placebo (P = 0.031).
Einfach gesagt: Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Abdulla SA et al. · Clinical and experimental dental research (2025)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Adjunctive antioxidants significantly improved CAL (melatonin: SMD -2.28, 95% CI -3.01 to -1.56; propolis: SMD -3.83, -4.79 to -2.87) and PD (melatonin: SMD -2.40, -3.14 to -1.66; propolis: SMD -1.78, -2.44 to -1.11).
Melatonin and propolis also reduced HbA1c (melatonin: SMD -2.28; propolis: SMD -3.83).
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Einfach gesagt: According to our result, propolis supplementation can decrease serum levels of IL-6, CRP, and TNF-α; therefore, it might be considered as complementary therapy for the treatment of certain chronic diseases.
Gholami A et al. · Journal of health, population, and nutrition (2024)
According to our result, propolis supplementation can decrease serum levels of IL-6, CRP, and TNF-α; therefore, it might be considered as complementary therapy for the treatment of certain chronic diseases.
Einfach gesagt: These results suggest that bioactive compounds of plant-based foods and medicinal plants have promising effects in terms of preventing or treating CKD progression and appear to improve inflammation and antioxidant capacity and support cardiovascular benefits and renoprotective effects; however, it is recommended that further studies be carried out.
14Fasting plasma glucose reductionMeta-Analysen=373 · medium study2019
Einfach gesagt: This systematic review and meta-analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients.
Karimian J et al. · Phytotherapy research : PTR (2019)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The results of the meta-analysis revealed significant reductions in fasting plasma glucose (-13.51 mg/dl; 95% CI [-24.98, -2.04]) and hemoglobin A1C (-0.52%; 95% CI [-0.94, -0.10]) concentrations following propolis supplementation.
However, no significant lowering effect was observed in fasting insulin levels (-0.53 pmol/L; 95% CI [-1.69, 0.63]) or homeostasis model assessment of insulin resistance (-0.543; 95% CI [-1.72, 0.64]).
This systematic review and meta-analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients.
Einfach gesagt: Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.
Sales-Peres SHC et al. · Brazilian oral research (2023)
The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001).
The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses.
Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity.
Einfach gesagt: Although there are a number of promising indications, in view of the limited number and quality of studies and the variation in results among studies, this review highlights the need for additional well-designed trials to draw conclusions that are more robust.
Hwu YJ et al. · The journal of nursing research : JNR (2014)
The result of the meta-analysis indicated that, although propolis had an effect on reducing dental plaque, this effect was not statistically significant.
The results were not statistically significant for oral infection or stomatitis.
Although there are a number of promising indications, in view of the limited number and quality of studies and the variation in results among studies, this review highlights the need for additional well-designed trials to draw conclusions that are more robust.
20Healing time for HSV-induced lesionsMeta-Analyse2022
Einfach gesagt: Overall, these results confirm the use of honey and propolis as potent antiherpetic agents.
Rocha MP et al. · Journal of ethnopharmacology (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The analysis of these studies showed that the healing property of propolis is superior to that obtained for acyclovir (95% CI: 2.70 to 8.25; p = 0.0001).
Furthermore, honey also presented a better healing effect than acyclovir against Herpes simplex virus-induced wounds (95% CI: 3.58 to -0.19; p = 0.03), inducing complete re-epithelization of herpetic lesions after 8 days, while for acyclovir, the healing time average was 9 days.
It also provoked a similar reduction of pain caused by herpetic compared to acyclovir (95% CI: 2.27 to -0.42; p = 0.18).