Pterostilbene
Methylated resveratrol analog with 4x better bioavailability — activates sirtuins for longevity, cognition, and metabolic benefits.
Pterostilbene is a naturally occurring polyphenol found in blueberries and grapes. It's structurally similar to resveratrol but has two methyl groups that dramatically improve its bioavailability and cellular uptake. Like resveratrol, it activates sirtuins and has antioxidant properties, but its superior absorption makes it more practical for supplementation. Research suggests benefits for brain health, metabolic function, and longevity.
Activates SIRT1 longevity pathway
Neutralizes free radicals and reduces oxidative stress
Crosses blood-brain barrier to protect neurons
How Pterostilbene works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
50-100mg daily
Loading: Not required
Take with food
| Form | Type |
|---|---|
| 💊Pterostilbene capsules | Recommended |
| 💊Pterostilbene + Resveratrol combinations | Alternative |
| 💊pTeroPure (branded form) | Alternative |
pTeroPure is a patented, well-researched form. Superior bioavailability compared to resveratrol.
Minimum: 8 weeks
Optimal: 24 weeks
Cycling: Not required
Note: Fat-soluble; taking with a meal containing fat improves absorption. Often combined with resveratrol for synergistic effects.
Improved memory and mental clarity
Better cholesterol and triglyceride levels
Reduced markers of oxidative stress
May slightly increase blood pressure in some
Avoid; insufficient safety data
Monitor blood pressure carefully
May affect blood pressure; monitor levels
Theoretical interaction; monitor if combining — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
Tip: Monitor blood pressure; reduce dose if needed
Tip: Take with food
Related polyphenols with overlapping mechanisms
Enhanced sirtuin activation and antioxidant coverage
Pterostilbene activates sirtuins (SIRT1) directly, while NR provides the NAD+ substrate for sirtuin activity — together they amplify sirtuin-dependent longevity and anti-inflammatory pathways.
Enhanced sirtuin activation, greater NAD+ metabolome elevation, and synergistic anti-inflammatory effects; studied together in multiple RCTs
Top studies from 37+ peer-reviewed papers
Zhou DD et al. • Sub-cellular biochemistry (2024)
“The Author(s), under exclusive license to Springer Nature Switzerland AG.”
Nowacka A et al. • International journal of molecular sciences (2024)
“The multifaceted nature of resveratrol's biological effects, including its influence on diverse physiological processes, underscores its potential as a valuable therapeutic option for the treatment of central nervous system tumors.”
Özyalçın B et al. • Critical reviews in food science and nutrition (2024)
“However, optimal dose, duration, mechanism, long-term safety, side effects, combination, elucidation of genomic interactions, and lifestyle modifications should be considered.”
Freeberg KA et al. • The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
“For permissions, please e-mail: journals.permissions@oup.com.”
Akinwumi BC et al. • International journal of molecular sciences (2018)
“Therefore, further research is warranted to evaluate the salutary effects of various stilbenoids.”
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