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RAD-140 (Testolone) — selective androgen receptor modulator (SARM)
An unapproved selective androgen receptor modulator (SARM) sold grey-market for muscle and body composition. Its anabolic and anti-cancer data are preclinical (cells/animals); the only human studies are a Phase-1 breast-cancer safety trial and case reports of severe liver injury. WADA-banned, suppresses natural testosterone, and grey-market products are routinely mislabeled.
Research compound — not a dietary supplement
RAD-140 (Testolone) is a research compound, not a regulated dietary supplement. It is sold for research or off-label use. The evidence below is largely preclinical (animal and in-vitro) or early-stage, so no evidence score is assigned. This page is provided for transparency and education — it is not a recommendation to use. Consult a qualified healthcare provider, and be aware that purity, dosing, and legal status vary by jurisdiction.
What the evidence says
Most RAD-140 (Testolone) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 2011–2024 with a typical study size of 22 participants.
Based on 6 studies · 22 total participants
Confidence
Low confidenceBy outcome
RAD-140's anabolic and anti-cancer data are entirely preclinical (cells/animals) — there are NO human efficacy trials for muscle or strength. The only human evidence is a Phase-1 breast-cancer safety trial (in which liver enzymes commonly rose) and multiple case reports of severe drug-induced liver injury. It suppresses natural testosterone, is WADA-banned, and grey-market products are routinely mislabeled. The score reflects a documented human harm signal with no proven human benefit.
RAD-140 (testolone) is a nonsteroidal selective androgen receptor modulator (SARM) discovered as a drug candidate to activate the androgen receptor in muscle and bone while sparing the prostate.
It was originally developed for muscle-wasting conditions and later studied as an androgen-receptor-targeted agent in androgen/estrogen-receptor-positive breast cancer.
It is NOT an approved drug or a dietary supplement anywhere — it is a research chemical that has become popular on the grey market for body composition and 'recomp.' The honest evidence picture is narrow and unflattering: the muscle/anabolic and anti-cancer findings are preclinical (cell-line, xenograft, and animal models, led by the 2011 discovery paper from Radius Health); there are NO human efficacy trials for muscle or strength.
The single substantial human study is a first-in-human Phase-1 dose-escalation in metastatic breast cancer, which was a safety/PK study (not an efficacy RCT) and in which liver-enzyme elevations were among the most common adverse events.
Outside that trial, the human literature is dominated by case reports of severe drug-induced liver injury (cholestatic hepatitis, jaundice) in young men taking RAD-140 for bodybuilding.
Like all androgen-receptor agonists it suppresses the hypothalamic-pituitary-gonadal axis (lowering natural testosterone), and it is prohibited at all times by WADA.
Chemical analyses of products sold online show frequent mislabeling — the stated SARM is often missing, substituted, under- or over-dosed, or spiked with other undeclared drugs. The score is low: no human efficacy evidence, documented serious human harm, regulatory prohibition, and an unreliable grey-market supply.
Binds the androgen receptor with high affinity and activates it preferentially in muscle and bone while sparing the prostate (tissue-selective in preclinical models).
AR activation drives anabolic gene programs in muscle and bone in animal/in-vitro models — the basis of its body-composition use, unproven in humans.
Like other androgen-receptor agonists, it suppresses the hypothalamic-pituitary-gonadal axis, lowering endogenous testosterone.
How RAD-140 (Testolone) works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Avoid — unapproved research chemical with a documented serious-harm signal and no proven human benefit.
Prohibited at all times by WADA; a positive test results from any use.
Especially dangerous — RAD-140 causes drug-induced liver injury.
Additive risk of drug-induced liver injury, which is already documented with RAD-140 alone.
Additive androgenic load and HPTA suppression; combined hepatic and hormonal risk.
Tip: Multiple case reports after bodybuilding use; stop immediately and seek care for jaundice, dark urine, or right-upper-quadrant pain. No safe dose established.
Tip: Among the most common adverse events in the Phase-1 trial; monitor liver function — though no use is recommended.
Tip: HPTA suppression is expected with androgen-receptor agonists; recovery is not characterized in trials.
RAD-140 (Testolone) has an evidence score of 3.2/10 — emerging evidence based on 6 indexed studies. An unapproved selective androgen receptor modulator (SARM) sold grey-market for muscle and body composition. Its anabolic and anti-cancer data are preclinical (cells/animals); the only human studies are a Phase-1 breast-cancer safety trial and case reports of severe liver injury. WADA-banned, suppresses natural testosterone, and grey-market products are routinely mislabeled. Representative study: PMID 34565686.
The commonly studied dose of RAD-140 (Testolone) is No legitimate dosing exists — RAD-140 is an unapproved research chemical, not a supplement or medicine. Grey-market protocols cite ~10 mg/day, but products are frequently mislabeled and this is not a recommendation.. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take RAD-140 (Testolone) is in the morning. It can be taken on an empty stomach. There is no validated human dosing.
RAD-140 (Testolone) should be used with caution — talk to a healthcare provider before taking it. The most commonly reported side effects are drug-induced liver injury (cholestatic hepatitis, jaundice), elevated liver enzymes (AST/ALT), testosterone suppression (low libido, fatigue, mood changes). Use caution if any of these apply to you: Anyone — unapproved research chemical with documented severe liver injury; Liver disease or elevated liver enzymes; Athletes subject to anti-doping (prohibited at all times by WADA).
Epicatechin
Probably helpsDark chocolate flavanol with consistent human evidence for improved endothelial function and modest blood pressure reduction. Muscle-building claims are not supported in humans.
Caffeine
Likely helpsBlocks adenosine receptors to boost alertness, reaction time, and endurance — one of the most proven ergogenic aids.
CoQ10
Likely helpsA lipid-soluble antioxidant central to mitochondrial energy production, with the strongest trial support for fertility/IVF outcomes and heart failure.
Sodium Bicarbonate
Likely helpsProven ergogenic aid that buffers lactic acid, extending high-intensity exercise capacity by 1-3%.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 6 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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