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RAD-140 (Testolone) — selective androgen receptor modulator (SARM)
A selective androgen receptor modulator (SARM) sold grey-market for muscle and body composition. Its anabolic and anti-cancer data are preclinical (cells/animals); the only human studies are a Phase-1 breast-cancer safety trial and case reports of severe liver injury. WADA-banned, suppresses natural testosterone, and grey-market products may have unreliable identity, strength or quality.
Research compound — not a dietary supplement
RAD-140 (Testolone) is a research compound, not a regulated dietary supplement. It is sold for research or off-label use. The evidence below is largely preclinical (animal and in-vitro) or early-stage, so no evidence score is assigned. This page is provided for transparency and education — it is not a recommendation to use. Consult a qualified healthcare provider, and be aware that purity, dosing, and legal status vary by jurisdiction.
What the evidence says
Most RAD-140 (Testolone) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 2011–2024 with a typical study size of 22 participants.
Based on 6 studies · 22 total participants
Confidence
Low confidenceBy outcome
RAD-140's anabolic and anti-cancer data are entirely preclinical (cells/animals) — there are NO human efficacy trials for muscle or strength. The only human evidence is a Phase-1 breast-cancer safety trial (in which liver enzymes commonly rose) and multiple case reports of severe drug-induced liver injury. It suppresses natural testosterone, is WADA-banned, and grey-market products may have unreliable identity, strength or quality. The score reflects a documented human harm signal with no proven human benefit.
RAD-140 (testolone) is a nonsteroidal selective androgen receptor modulator (SARM) discovered as a drug candidate to activate the androgen receptor in muscle and bone while sparing the prostate.
It was originally developed for muscle-wasting conditions and later studied as an androgen-receptor-targeted agent in androgen/estrogen-receptor-positive breast cancer. RAD-140 is studied as an investigational androgen-receptor modulator. SupStack does not recommend self-directed use.
Material sold online may have unreliable identity, strength or quality, and the available research does not establish safety for self-experimentation.
The honest evidence picture is narrow and unflattering: the muscle/anabolic and anti-cancer findings are preclinical (cell-line, xenograft, and animal models, led by the 2011 discovery paper from Radius Health); there are NO human efficacy trials for muscle or strength.
The single substantial human study is a first-in-human Phase-1 dose-escalation in metastatic breast cancer, which was a safety/PK study (not an efficacy RCT) and in which liver-enzyme elevations were among the most common adverse events.
Outside that trial, the human literature is dominated by case reports of severe drug-induced liver injury (cholestatic hepatitis, jaundice) in young men taking RAD-140 for bodybuilding.
Like all androgen-receptor agonists it suppresses the hypothalamic-pituitary-gonadal axis (lowering natural testosterone), and it is prohibited at all times by WADA.
In an analysis of 13 SARM products bought from websites accessible from Italy in 2022 (Gaudiano 2024), about 70% contained the stated SARM, 30% contained other undeclared drugs, and the measured content ranged from 30% to 90% of the label claim.
The score is low: no human efficacy evidence, documented serious human harm, regulatory prohibition, and an unreliable grey-market supply.
Binds the androgen receptor with high affinity and activates it preferentially in muscle and bone while sparing the prostate (tissue-selective in preclinical models).
AR activation drives anabolic gene programs in muscle and bone in animal/in-vitro models — the basis of its body-composition use, unproven in humans.
Like other androgen-receptor agonists, it suppresses the hypothalamic-pituitary-gonadal axis, lowering endogenous testosterone.
How RAD-140 (Testolone) works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Avoid — research chemical with a documented serious-harm signal and no proven human benefit.
Prohibited at all times by WADA; a positive test results from any use.
Especially dangerous — RAD-140 causes drug-induced liver injury.
Additive risk of drug-induced liver injury, which is already documented with RAD-140 alone.
Additive androgenic load and HPTA suppression; combined hepatic and hormonal risk.
Tip: Multiple case reports after bodybuilding use; stop immediately and seek care for jaundice, dark urine, or right-upper-quadrant pain. No safe dose established.
Tip: Among the most common adverse events in the Phase-1 trial; monitor liver function — though no use is recommended.
Tip: HPTA suppression is expected with androgen-receptor agonists; recovery is not characterized in trials.
RAD-140 (Testolone) has an evidence score of 3.2/10 — emerging evidence based on 6 indexed studies. A selective androgen receptor modulator (SARM) sold grey-market for muscle and body composition. Its anabolic and anti-cancer data are preclinical (cells/animals); the only human studies are a Phase-1 breast-cancer safety trial and case reports of severe liver injury. WADA-banned, suppresses natural testosterone, and grey-market products may have unreliable identity, strength or quality. Representative study: PMID 34565686.
Dosing for RAD-140 (Testolone): No self-directed dose is recommended by SupStack. RAD-140 is a research chemical, not a supplement or medicine, products from unverified sources may have unreliable identity, strength or quality, and no dose is endorsed. The one cited human trial gave 50, 100 and 150 mg once daily to women with metastatic breast cancer, a patient-population exposure, not a consumer dose.
The best time to take RAD-140 (Testolone) is in the morning. It can be taken on an empty stomach. There is no validated human dosing.
No consumer dose of RAD-140 (Testolone) is endorsed, so there is no dose at which it can be called safe. Talk to a healthcare provider before taking it. Reported side effects include drug-induced liver injury (cholestatic hepatitis, jaundice), elevated liver enzymes (AST/ALT), testosterone suppression (low libido, fatigue, mood changes). How often they occur is not established for all of them. Use caution if any of these apply to you: Anyone — research chemical with documented severe liver injury; Liver disease or elevated liver enzymes; Athletes subject to anti-doping (prohibited at all times by WADA).
Caffeine
Probably helpsBlocks adenosine receptors to boost alertness, reaction time, and endurance — an umbrella review of 21 meta-analyses found it ergogenic for endurance, strength and power.
CoQ10
Likely helpsA lipid-soluble antioxidant central to mitochondrial energy production, with the strongest trial support for fertility/IVF outcomes and heart failure.
Sodium Bicarbonate
Likely helpsErgogenic aid that buffers metabolic acid. An umbrella review of meta-analyses found it improves peak anaerobic power and efforts lasting about 45 seconds to 8 minutes, on moderate to low quality evidence.
Alpha-GPC
Too few graded studiesA choline source that crosses the blood-brain barrier. Trials show cognitive gains in people with dementia or after stroke. In healthy adults the data are a few small, short studies.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 6 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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