39 peer-reviewed studies · Evidence score: 7.5/10
Hernandez AV et al. • Journal of dietary supplements (2024)
Berberine, alone or with other nutraceuticals, can provide a modest positive impact on lipid concentrations.
Osadnik T et al. • Pharmacological research (2022)
Evidence for bergamot effect was based on relatively small study group and may require further investigations.
Cicero AFG et al. • Nutrients (2021)
These changes are consistent with improved cardiometabolic health.
Liasi E et al. • Semergen (2024)
Low doses of monacolin K equal to 3mg/day exert potential cholesterol-lowering effects although the number of relative studies is limited.
Pirro M et al. • Pharmacological research (2016)
Inverse variance-weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated for net changes in lipid and glucose levels using a random-effects model.
Peng D et al. • The American journal of nursing (2017)
Although RYR appears to be a safe and effective lipid-lowering agent, there is insufficient evidence to support the recommendation of RYR supplementation to patients.
Xiong X et al. • Critical reviews in food science and nutrition (2017)
Further rigorously designed trials are warranted before RYR could be recommended to hypertensive patients.
Fogacci F et al. • American Journal of Cardiology (2019)
Red yeast rice effectively lowered LDL-C in statin-intolerant patients with significantly better tolerability than statins.
Li Y et al. • PloS one (2014)
The meta-analysis suggests that red yeast rice is an effective and relatively safe approach for dyslipidemia.
Ma ZY et al. • Journal of integrative medicine (2024)
The evidence examined in this study suggests that RYR preparations are safe; however, the credibility of the evidence was not high.
Trogkanis E et al. • Nutrients (2024)
Further research on specific subpopulations and outcomes could establish a consensus on determining the clinical benefits and potential risks, if any, of this nutraceutical.
Rahmani P et al. • Expert review of clinical pharmacology (2023)
In conclusion, this comprehensive article and meta-analysis showed that RYR significantly decreases TC, TG, and LDL-C as well as increases HDL-C.
Xu G et al. • Endocrinology, diabetes & metabolism (2022)
Xuezhikang was found to have the highest probability of being the most effective formulation for reducing total cholesterol and low-density lipoprotein cholesterol levels, while Zhibituo had the highest probability of being the most effective for controlling triglyceride and high-density lipoprotein cholesterol levels.
Ilyas Z et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2020)
In addition, Berberine is found to have a beneficial impact on gene regulation for the absorption of cholesterol at a daily dose of 300 mg in humans, an amelioration on glucose accumulation at 1.0 ...
Rondanelli M et al. • BioMed research international (2016)
Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.
Millán J et al. • Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis (2016)
This meta-analysis confirms that the nutraceutical combination containing berberine, policosanol, and red yeast rice has shown to be an effective product for the improvement of the lipid profile.
Sungthong B et al. • Scientific reports (2020)
This meta-analysis indicated that RYR extract in MI patients with borderline hypercholesterolemia is associated with improved cardiovascular outcomes and lipid profiles.
Ong YC et al. • Journal of clinical pharmacy and therapeutics (2016)
A number of small trials show that red yeast rice and simvastatin produce similar lipid-lowering effects.
Liu J et al. • Chinese Medicine (2006)
RYR significantly reduced LDL and total cholesterol.
Wu B et al. • BioMed research international (2020)
RYR can promote bone formation in experimental animals and may be useful for the treatment of osteoporosis.