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Ganoderma lucidum (Lingzhi)
Beta-glucan and triterpene-rich mushroom with calming properties that supports immune function, sleep quality, and stress resilience.
What the evidence says
Studies are split: Reishi helped in 2 of 6 cases, with the rest inconclusive or showing no benefit.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2026 with a typical study size of 78 participants.
Based on 42 studies · 4 meta-analyses · 10 RCTs · 3,622 total participants
Confidence
HighWhat the studies found
By outcome
Reishi has an evidence score of 7/10 — strong evidence based on 42 indexed studies, including 3 meta-analyses. Beta-glucan and triterpene-rich mushroom with calming properties that supports immune function, sleep quality, and stress resilience.
The commonly studied dose of Reishi is 1-3g dried mushroom or 500-1500mg extract. Research points to an estimated optimal dose around 2000mg, with a minimum effective dose near 1000mg. Individual response varies — start low and adjust.
The best time to take Reishi is in the evening. Taking it with food is preferred. Reishi (Ganoderma lucidum) contains calming triterpenoids (ganoderic acids) and immune-modulating polysaccharides (beta-glucans).
Last reviewed May 2026 · evidence from 39 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Reishi is a medicinal mushroom with over 2,000 years of use in Asian medicine. Known as the 'mushroom of immortality,' it contains beta-glucans and triterpenes that support immune function. Unlike stimulating adaptogens, reishi has calming properties that support sleep and stress resilience. Often used for immune support and general wellness.
Activates and balances immune function
Supports stress resilience with calming effects
How Reishi works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
1-3g dried mushroom or 500-1500mg extract
Can be taken without food
| Form | Type |
|---|---|
| 💊Dual-extract (water + alcohol) capsules or powder | Recommended |
| 💊Hot water extract | Alternative |
| 🧪Spore powder | Alternative |
Dual extraction captures both water-soluble beta-glucans and alcohol-soluble triterpenes. Look for fruiting body extracts.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Calming effects make evening dosing ideal. Can be taken any time for immune support.
Based on systematic reviews identifying immunostimulatory properties. Meta-analysis for cancer adjuvant therapy showed positive immune response (RR 1.50). Quality clinical data still needed. Effect varies significantly by extract type and standardization.
Enhanced immune function
Improved sleep quality and calmness
Better stress adaptation
Insufficient data; avoid
Use with caution — may stimulate immune system
May increase bleeding risk
May counteract immunosuppressive effects
May have additive blood pressure lowering
Possible reduced effectiveness, rejection risk
Tip: Take with food
Tip: Reduce dose
Tip: Stay hydrated
Different mushrooms with complementary effects
Reishi for calm/immune, cordyceps for energy
Both support immune function
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Broad-spectrum immune and antiviral support
Traditional combination for immune and longevity
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Both are immune-supporting mushrooms
Comprehensive immune and adaptogenic support
Reishi is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are GI upset, dizziness, dry mouth/throat. Use caution if any of these apply to you: Bleeding disorders; Before surgery; Autoimmune conditions (use with caution).
Ashwagandha
Likely helpsReduces cortisol and anxiety while improving sleep quality and physical recovery in stressed adults.
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