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Rs6.0
Resistant Starch – Forschung
Hilft wahrscheinlich
87 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Resistant Starch scheint in 15 von 15 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2005–2026 mit einer typischen Studiengröße von 47 Teilnehmenden.
Basierend auf 87 Studien · 18 Meta-Analysen · 44 RCTs · 4,817 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
15geholfen· 72 weitere ohne bewertete Effektdaten
Nach Outcome
Glucose & metabolicVerbessert die Insulinsensitivität über die SCFA-Produktion · 4-8 Wochen
Hilft wahrscheinlich75 Studien
Digestive healthPräbiotische Fermentation produziert Butyrat und unterstützt die Darmgesundheit · 2-4 Wochen
Hilft wahrscheinlich34 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung21 Studien
Weight management
Hilft wahrscheinlich20 Studien
Cholesterol & lipids
Hilft wahrscheinlich5 Studien
InflammationErhöhte Butyratproduktion und nützliche Bakterien · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Liver health
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 41 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
80%
über Studien hinweg
Untersuchte Personen
4,817
typische Studie: 47 Personen
Stärkste Designs
62
18 gepoolt, 44 randomisiert
Zeigte Nutzen
100%
15/15 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–4 Wochen
1
1–3 Monate
4
3+ Monate
1
Untersuchte Populationen
General population4
Adults3
Healthy adults2
Lynch syndrome patients2
Aktives Forschungsgebiet
62 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200520152026
1Fasting plasma glucose reductionMeta-Analyse2021
Einfach gesagt: The current study indicated moderate effects of resistant starch on improving glycaemic control.
Xiong K et al. · The British journal of nutrition (2021)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Significant reduction in fasting plasma glucose (ES -0.09 mmol/l; 95% CI -0.13, -0.04; P = 0.001) vs digestible starch
Significant improvement in HOMA-insulin resistance (ES -0.33; 95% CI -0.51, -0.14; P = 0.001)
Effect on fasting glucose was larger at doses >28 g/d or intervention periods >8 weeks; fasting insulin not significantly affected
2Gut microbiome alterationsMeta-Analysen=248 · medium study2023
Einfach gesagt: The altered gut microbiome may contribute to improve the blood glucose level and insulin resistance, which may be a potential treatment route for diabetes, obesity and other metabolic diseases.
Chen R et al. · Food & function (2023)
In this article, we performed a meta-analysis of a total of 955 samples of 248 individuals from the seven studies included to compare the gut microbiota of the baseline and the end-point of RS intake.
Different types of resistant starch and different populations led to varied responses on the gut microbiome.
The altered gut microbiome may contribute to improve the blood glucose level and insulin resistance, which may be a potential treatment route for diabetes, obesity and other metabolic diseases.
5Cardiometabolic outcomesMeta-Analysen=670 · large study2019
Einfach gesagt: Short-term RS2 supplementation in humans is of limited cardiometabolic benefit.
Snelson M et al. · Nutrients (2019)
However, these outcomes were heavily influenced by positive results from a small number of individual studies which contradicted the conclusions of the majority of trials.
RS2 had no effects on any other metabolic outcomes.
All studies ranged from 1-12 weeks in duration and contained small sample sizes (10-60 participants), and most had an unclear risk of bias.
Jia L et al. · International journal of medical sciences (2021)
Results: After screening 65 records, five RCTs (n = 179) were included.
Analyses of blood levels of uric acid, p-cresyl sulfate, indoxyl sulfate, high sensitive C-reaction protein, albumin and phosphorus yielded no significant difference.
Einfach gesagt: Additionally, more studies are needed to prove whether ingesting high-fiber carbohydrate-containing products per se can result in blunted glycemic and insulinemic responses and which DF type and amount are more effective.
Tsitsou S et al. · Nutrients (2023)
Data on insoluble DF and glucose metabolism are scarce.
The same mixed results for glycemia can be seen in healthy volunteers with overweight/obesity, while resistant starch seems to improve insulinemic responses.
Finally, more studies need to examine the acute effects of DF in starchy foods on glucose metabolism and insulin secretion in individuals facing glucose abnormalities.
13HOMA-S% improvementMeta-Analysen=428 · medium study2019
Einfach gesagt: This meta-analysis has provided evidence that RS supplementation can improve fasting glucose, fasting insulin, insulin resistance and sensitivity, especially for diabetic with overweight or obesity.
Wang Y et al. · Nutrition & diabetes (2019)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
RS supplementation increased HOMA-S% (SMD = 1.19; 95% CI: 0.59-1.78) and reduced HOMA-B (SMD =-1.2; 95% CI: -1.64 to -0.77), LDL-c concentration (SMD =-0.35; 95% CI: -0.61 to -0.09), and HbA1c (SMD = -0.43; 95% CI: -0.74 to -0.13) in overall analysis.
This meta-analysis has provided evidence that RS supplementation can improve fasting glucose, fasting insulin, insulin resistance and sensitivity, especially for diabetic with overweight or obesity.
However, owing to potential sophistication, individual difference and composition of intestinal microbiota, this result should be carefully taken into account.
Einfach gesagt: To decrease the rate of appetite more effectively, we suggest other researchers to identify RS dose and type.
Amini S et al. · Clinical nutrition ESPEN (2021)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Meta-analysis showed a lower appetite in RS group compared to the controls (weighted mean difference [WMD] = -1.375 mm min, 95% confidence interval [95%CI]: -1.673, -1.076).
Since high heterogeneity was observed among the included studies (I2 = 94.5%, P < 0.001), subgroup analysis was carried out by RS dose, RS type, duration of supplementation, and time of AUC measuring.
In studies that used RS dose of ≥25 gr, heterogeneity disappeared (P = 0.560, I2 = 0%).
Einfach gesagt: The meta-analysis of these data showed that RS supplementation has an effect on lowering TC and LDL-C (TC: mean difference, -7.33mg/dL [95% confidence interval -12.15 to -2.52mg/dL]; LDL-C: mean di...
Yuan HC et al. · Nutrition research (New York, N.Y.) (2018)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The meta-analysis of these data showed that RS supplementation has an effect on lowering TC and LDL-C (TC: mean difference, -7.33mg/dL [95% confidence interval -12.15 to -2.52mg/dL]; LDL-C: mean difference: -3.40mg/dL [95% confidence interval, -6.74 to -0.07mg/dL]).
Future research should focus on the relationship between RS type and cholesterol-lowering effects, and the effects on subjects of different health status or those with different baseline levels of serum lipids.
Moreover, the mechanism for the cholesterol-lowering effects of RS should be further explored.
Einfach gesagt: RS supplementation can ameliorate IR in T2DM, especially for the patients of T2DM with obesity, but not in simple obesity.
Gao C et al. · Lipids in health and disease (2019)
The results indicated that there was no significant difference in the amelioration of BMI, HOMA-%S and HOMA-%B in T2DM patients between RS and the non-RS supplementation.
RS supplementation can ameliorate IR in T2DM, especially for the patients of T2DM with obesity, but not in simple obesity.
Einfach gesagt: To conclude, our study found that resistant starch elicited a beneficial effect on the function of large bowel in healthy adults.[Formula: see text].
Shen D et al. · International journal of food sciences and nutrition (2017)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Animal experimental studies have found that resistant starch can significantly improve bowel function, but the outcomes are mixed while conducting human studies.
The standardized mean difference (SMD) or weighted mean difference (WMD) was calculated using a fixed-effects model or a random-effects model.
The pooled findings revealed that resistant starch significantly increased fecal wet weight (WMD 35.51 g/d, 95% CI 1.21, 69.82) and butyrate concentration (SMD 0.61, 95% CI 0.32, 0.89).
Einfach gesagt: Based on these results, there is fair evidence that prebiotics and substances with prebiotic properties may improve metabolic and inflammatory biomarkers related to T2DM in women aged 18 years at least.
Colantonio AG et al. · Journal of the Academy of Nutrition and Dietetics (2020)
Based on these results, there is fair evidence that prebiotics and substances with prebiotic properties may improve metabolic and inflammatory biomarkers related to T2DM in women aged 18 years at least.
Interventions with resistant starch, resistant dextrin, and oligofructose-enriched inulin exhibited the strongest evidence for improvements due to the quantity of publications and quality grades.
Other prebiotics and substances with prebiotic properties show promise but the number of studies is few.
19Fasting plasma glucoseMeta-Analysen=14 · very small study2020
Einfach gesagt: This meta-analysis showed beneficial effects of RS on improving FPG, insulin, HbA1c, total cholesterol, LDL-cholesterol and TNF-α levels in patients with MetS and related disorders, but it did not affect HOMA-IR, triglycerides, HDL-cholesterol, CRP and IL-6 levels.
Halajzadeh J et al. · Critical reviews in food science and nutrition (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.
Administration of RS resulted in significant reduction in fasting plasma glucose (FPG) (14 studies) (WMD: -4.28; 95% CI: -7.01, -1.55), insulin (12 studies) (WMD: -1.95; 95% CI: -3.22, -0.68), and HbA1C (8 studies) (WMD: -0.60; 95% CI: -0.95, -0.24).
When pooling data from 13 studies, a significant reduction in total cholesterol levels (WMD: -8.19; 95% CI: -15.38, -1.00) and LDL-cholesterol (WMD: -8.57; 95% CI: -13.48, -3.66) were found as well.