Resveratrol

Both target longevity pathways

Resveratrol activates sirtuins; NMN provides NAD+ fuel

⟡ Pterostilbene

Related polyphenols with overlapping mechanisms

Enhanced sirtuin activation and antioxidant coverage

⟡ Spermidine

Both activate longevity pathways

Multiple mechanisms for healthy aging

⟡ Nicotinamide Riboside

Resveratrol activates SIRT1 and AMPK pathways; NR provides the NAD+ substrate. Together they support mitochondrial biogenesis and longevity signaling.

Complementary activation of NAD+-SIRT1 axis for mitochondrial health and longevity

Top studies from 39+ peer-reviewed papers

📚meta-analysisn=614

Lahouti M et al. • Phytotherapy research : PTR (2025)

“Further high-quality, long-term studies are necessary to confirm these findings.”

Key Findings:

We determined overall effect sizes using a random-effects model and assessed heterogeneity using the I 2 statistic and Cochrane's Q test.
This meta-analysis revealed significant reductions in body weight, BMI, and WC among T2D patients who consumed resveratrol.
However, we did not find any significant effects on HC or WHR.
Further high-quality, long-term studies are necessary to confirm these findings.

📚systematic-reviewn=200

Brown K et al. • International journal of molecular sciences (2024)

“In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.”

Key Findings:

Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism.
In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.

📚meta-analysisn=3650

Zhou P et al. • PloS one (2024)

“The rankings of safety and efficacy of the 12 antioxidants vary.”

Key Findings:

The rankings of safety and efficacy of the 12 antioxidants vary.
Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
More high-quality studies are still needed to verify our findings.

📚systematic-review

Bertoldo A et al. • International journal of molecular sciences (2024)

“Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.”

Key Findings:

The current literature, though limited, suggests that resveratrol may play a role in female infertility.
Specifically, it may significantly and positively impact reproductive outcomes, owing to its potential therapeutic effects improving ovarian function.
Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.

📚meta-analysisn=3852

Compare with Others Find Based on Your Goals

Long Z et al. • Frontiers in immunology (2023)

“Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.”

Key Findings:

Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
Further research warranted to confirm findings

View all 39+ studies

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Resveratrol

compound

Trans-Resveratrol

Polyphenol found in red wine and grapes, studied for its potential anti-aging and cardiovascular benefits through sirtuin activation.

longevityantioxidantcardiovascularsirtuinsanti-aging

39+ studies

Evidence

Reviewed 19 days ago

moderate

Safety

150-500mg trans-resveratrol

Dose

4-12 weeks

Time to Effect

Trans-resveratrol capsules

Best Form

Mechanisms of Action

🧬

Sirtuin Activation

Activates longevity-associated proteins

🛡️

Antioxidant Effects

Neutralizes harmful free radicals

🔥

Anti-Inflammatory

Reduces inflammatory signaling

Biological PathwayBeta

How Resveratrol works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Supplement

Molecular Target

Biological Process

Health Outcome

Strong

Moderate

Emerging

strong

moderate

emerging

Tap node to isolate • Pinch to zoom • Tap edge for research

Recommended Dose

150-500mg trans-resveratrol

100mg1000mg

Optimal Timing

With a meal containing fat

Take with food

Available Forms

Form	Type
💊Trans-resveratrol capsules	Recommended
💊Micronized resveratrol	Alternative
💊Liposomal	Alternative

Trans-resveratrol is the active form. Look for products specifying trans-resveratrol content. Micronized forms may have better absorption.

Duration

Minimum: 4 weeks

Optimal: 12 weeks

Cycling: Not required

Note: Fat improves absorption. Some evidence suggests taking with quercetin may enhance effects. Bioavailability is generally low.

❤️

Cardiovascular Support

May support heart and blood vessel health

⏱️ 4-12 weeks

55% of users notice thispositive

🔥

Reduced Inflammation

Lower inflammatory markers

⏱️ 4-8 weeks

50% of users notice thispositive

ModerateMax safe dose: Up to 1000mg/day shown safe short-term

🔴

Pregnant/nursing

Avoid due to estrogenic activity and insufficient data

🟡

Those on medications

Consult doctor due to CYP450 interactions

Who Should NOT Take This

Bleeding disorders
Hormone-sensitive conditions
Before surgery

Drug Interactions

Blood thinners (Warfarin)moderate

May increase bleeding risk

CYP450 substratesmoderate

May affect metabolism of many drugs

Hormone therapiesmild

Has mild estrogenic activity

Possible Side Effects

GI upset

milduncommon

Tip: Take with food

Diarrhea (high doses)

milduncommon

Tip: Reduce dose

Warnings

Low bioavailability — much is metabolized before reaching bloodstream
Human evidence less impressive than animal studies
May have weak estrogenic effects

✦ Quercetin

enhances

Quercetin may inhibit resveratrol metabolism

Improved resveratrol bioavailability and combined antioxidant effects

⟡ NMN

Both target longevity pathways

Resveratrol activates sirtuins; NMN provides NAD+ fuel

⟡ Pterostilbene

Related polyphenols with overlapping mechanisms

Enhanced sirtuin activation and antioxidant coverage

⟡ Spermidine

Both activate longevity pathways

Multiple mechanisms for healthy aging

⟡ Nicotinamide Riboside

Resveratrol activates SIRT1 and AMPK pathways; NR provides the NAD+ substrate. Together they support mitochondrial biogenesis and longevity signaling.

Complementary activation of NAD+-SIRT1 axis for mitochondrial health and longevity

Top studies from 39+ peer-reviewed papers

📚meta-analysisn=614

Lahouti M et al. • Phytotherapy research : PTR (2025)

“Further high-quality, long-term studies are necessary to confirm these findings.”

Key Findings:

We determined overall effect sizes using a random-effects model and assessed heterogeneity using the I 2 statistic and Cochrane's Q test.
This meta-analysis revealed significant reductions in body weight, BMI, and WC among T2D patients who consumed resveratrol.
However, we did not find any significant effects on HC or WHR.
Further high-quality, long-term studies are necessary to confirm these findings.

📚systematic-reviewn=200

Brown K et al. • International journal of molecular sciences (2024)

“In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.”

Key Findings:

Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism.
In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.

📚meta-analysisn=3650

Zhou P et al. • PloS one (2024)

“The rankings of safety and efficacy of the 12 antioxidants vary.”

Key Findings:

The rankings of safety and efficacy of the 12 antioxidants vary.
Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
More high-quality studies are still needed to verify our findings.

📚systematic-review

Bertoldo A et al. • International journal of molecular sciences (2024)

“Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.”

Key Findings:

The current literature, though limited, suggests that resveratrol may play a role in female infertility.
Specifically, it may significantly and positively impact reproductive outcomes, owing to its potential therapeutic effects improving ovarian function.
Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.

📚meta-analysisn=3852

Compare with Others Find Based on Your Goals

Long Z et al. • Frontiers in immunology (2023)

“Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.”

Key Findings:

Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
Further research warranted to confirm findings

View all 39+ studies

What would you like to do next?

Related Supplements

Si9.0

Soy Isoflavones

Plant compounds with weak estrogenic effects that support menopausal symptoms, bone health, and cardiovascular function.

Qrc8.0

Quercetin

8/10

Flavonoid with senolytic and anti-inflammatory properties — supports immune defense, allergy relief, and exercise performance.

Bbr9.0

Berberine