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Rho5.5
Rhodiola Rosea – Forschung
Hilft wahrscheinlich
75 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Rhodiola Rosea half in etwa der Hälfte (2/3) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1999–2026 mit einer typischen Studiengröße von 55 Teilnehmenden.
Basierend auf 75 Studien · 4 Meta-Analysen · 47 RCTs · 2,687 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen1unklar· 72 weitere ohne bewertete Effektdaten
Nach Outcome
Energy & fatigueReduzierte geistige und körperliche Erschöpfung · 1 Woche
Hilft vermutlich59 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung17 Studien
Anxiety & stressVerbesserte Stressresilienz · 1-2 Wochen · Verbesserte Resilienz gegenüber chronischem Stress, reduzierte Erschöpfung unter Belastung · 1-2 Wochen
Überwiegend Mechanismus / Beobachtung16 Studien
Cognitive functionVerbessert die kognitive Funktion unter Erschöpfung und Stress · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung15 Studien
Endurance & exercise performanceVerzögert das wahrgenommene Anstrengungsempfinden und verbessert die Zeit bis zur Erschöpfung · 2-4 Wochen · Reduziert Erschöpfung; verbessert die Zeit bis zur Erschöpfung · 1-4 Wochen
Überwiegend Mechanismus / Beobachtung13 Studien
Depression & moodReduziert Burnout und Erschöpfung, verbessert Wohlbefindens-Scores in RCTs · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung11 Studien
Recovery
Überwiegend Mechanismus / Beobachtung7 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung7 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Sleep & insomnia
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Circadian rhythm & jet lagAdaptogen mit RCTs zu Jetlag und Schichtarbeit · 1 Woche
Zu wenige bewertete Studien1 Studie
Women's healthKann menstruelle Beschwerden und PMS-Symptome lindern · 1-3 Zyklen
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 31 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
63%
über Studien hinweg
Untersuchte Personen
2,687
typische Studie: 55 Personen
Stärkste Designs
51
4 gepoolt, 47 randomisiert
Zeigte Nutzen
67%
2/3 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–4 Wochen
2
1–3 Monate
5
3+ Monate
1
Untersuchte Populationen
Adults2
Athletes/exercising individuals2
Adults with mild depression1
Adults with chronic fatigue1
Aktives Forschungsgebiet
30 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199920122026
1Depression response ratesMeta-Analysen=1,049 · large study2025
Einfach gesagt: This review demonstrates that certain supplements, such as eicosapentaenoic acids and Rhodiola rosea, are therapeutic options for mild depression.
Urata M et al. · Neuropsychopharmacology reports (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88).
Eicosapentaenoic acid and Rhodiola rosea demonstrated significant improvements in depressive symptoms compared to placebo.
Conversely, S-adenosylmethionine did not produce significant improvements relative to placebo.
Chu JF, Wu GW, Zheng GH, Zheng F, Xu JF, Peng J · Zhongguo Zhong Xi Yi Jie He Za Zhi (2014)
4Chronic fatigue and cognitive impairment treatmentÜbersicht2021
Einfach gesagt: In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.
Todorova V et al. · Nutrients (2021)
About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body's resistance to stress and to improve physical endurance.
Although now many people take plant adaptogens, the clinical trials on human are limited.
The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection.
Einfach gesagt: Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.
Crawford C et al. · Journal of alternative and complementary medicine (New York, N.Y.) (2021)
Ingredients evaluated included Bacopa monnieri, choline, creatine, omega-3 fatty acids, Ginkgo biloba, ginseng, Rhodiola rosea, tyrosine, and valerian root, all in supplement form and compared with a placebo, at various serving sizes and durations of use.
Whereas certain trends regarding promising serving sizes or duration for use, are pointed to in this synthesis, when combined, studies are inconsistent and imprecise, and many are methodologically flawed.
Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.
Einfach gesagt: Rhodiola rosea showed clinically meaningful antidepressant and anti-fatigue effects with a favorable safety profile compared to conventional antidepressants.
Anghelescu IG et al. · Phytomedicine (2018)
Significant improvements in depression rating scales vs placebo
Anti-fatigue effects observed across multiple clinical trials
Fewer adverse effects compared to sertraline in head-to-head comparison
Einfach gesagt: Analysis of evidence levels was conducted, as were effect sizes (Cohen's d) where data were available.
Sarris J et al. · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2011)
Analysis of evidence levels was conducted, as were effect sizes (Cohen's d) where data were available.
Several human clinical trials provide preliminary positive evidence of antidepressant effects (Echium amoenum, Crocus sativus, and Rhodiola rosea) and anxiolytic activity (Matricaria recutita, Ginkgo biloba, Passiflora incanata, E. amoenum, and Scutellaria lateriflora).
Caution should however be taken when interpreting the results as many studies have not been replicated.
Einfach gesagt: Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of R. rosea main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects.
Bernatoniene J et al. · International journal of molecular sciences (2023)
Recent studies indicate that R. rosea may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer's and Parkinson's diseases.
This paper reviews the beneficial effects of the extract of R. rosea, its key active components, and their possible use in the treatment of chronic diseases.
R. rosea represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases.
Einfach gesagt: Particular attention is given to clinical and safety issues with St John's wort and kava.(c) 2007 John Wiley & Sons, Ltd.
Sarris J · Phytotherapy research : PTR (2007)
While depression and anxiety are commonly researched, the efficacy of herbal medicines in other mental disorders requires attention.
The review addresses current issues in herbal psychotherapy: herbal safety, future areas of application, the relationship of herbal medicine with pharmaceuticals and the potential prescriptive integration of phytomedicines with synthetic psychotropic medicines.
Particular attention is given to clinical and safety issues with St John's wort and kava.
16Oxygen uptake during high-intensity exerciseRCTn=50 · small study2024
Einfach gesagt: Salidroside supplementation may enhance oxygen utilization and mitigate exercise-induced muscle damage and fatigue, warranting further research on its long-term effects and potential as an adaptogen for active individuals.
Schwarz NA et al. · Journal of the International Society of Sports Nutrition (2024)
An increase in serum myoglobin was observed 24 hours following exercise in the placebo group (p = 0.02) compared with baseline whereas no statistically significant increase was observed for the salidroside group indicating reduced exercise-induced muscle damage.
Salidroside supplementation may enhance oxygen utilization and mitigate exercise-induced muscle damage and fatigue, warranting further research on its long-term effects and potential as an adaptogen for active individuals.
Einfach gesagt: Integrative medicine approaches in the clinical practice may help improve the health of women suffering from this and other gynecological conditions.
Herrera A et al. · Journal of dietary supplements (2024)
On the contrary, the between-group analysis showed no statistical differences, suggesting a plausible placebo effect.
The phytotherapeutic supplement PREMEN-CALM® might be effective in treating or alleviating the symptoms of the premenstrual syndrome without adverse events.
Integrative medicine approaches in the clinical practice may help improve the health of women suffering from this and other gynecological conditions.