We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Rutin / Oxerutins (Hydroxyethylrutosides)
A flavonoid (rutin) whose semi-synthetic derivatives — hydroxyethylrutosides/oxerutins (Venoruton) — have meta-analysis evidence for modestly improving chronic venous insufficiency symptoms. Most evidence is for the rutoside derivative, not plain rutin.
What the evidence says
Rutin doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1982–2026 with a typical study size of 136 participants.
Based on 67 studies · 3 meta-analyses · 57 RCTs · 226 total participants
Confidence
High confidenceBy outcome
A 15-trial meta-analysis shows hydroxyethylrutosides modestly improve chronic-venous-insufficiency symptoms, but the evidence is for rutoside derivatives, not plain rutin, capping it at moderate.
61 randomised trials
every one checked individually
Every randomised or controlled trial of Rutin indexed in PubMed, not a hand-picked subset. Meta-analyses and systematic reviews are deliberately excluded from this count: most of them cover many compounds at once, so counting them would inflate it.
PubMed · as of Jul 2026
12 trials ongoing or recruiting · 36 completed on ClinicalTrials.gov
Registered trials show research momentum for Rutin, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Oct 2026
Under EU law (Reg. 1924/2006), EFSA reviews whether a specific health claim for Rutin meets the evidence standard. These are independent regulatory decisions on claims — not studies, and never counted toward the evidence score above.
Not authorised by EFSA
“Coldizin helps support the immune system”
“Rutoside Helps to maintain capillary integrity”
“Troxerutin Contributes to the normal functioning of the veins”
“Rutin A strong antioxidant that protects the body’s cells from the harmful effects of free radicals; Improves the immune system”
“Rutin Promotes the functioning of blood vessels (arteries, veins, capillaries), normalizes penetrability, health and elasticity of the blood vessel walls”
“Not authorised” means the specific claim wording did not meet the EU’s evidence standard — often a matter of dossier or phrasing, not proof of no effect. EFSA judges marketing claims and is kept separate from our study-based evidence score.
Source: EU Register of nutrition and health claims (European Commission / EFSA) · register snapshot Feb 2013
Rutin is a flavonoid (quercetin-3-O-rutinoside) found in buckwheat, citrus, and other plants. Its venoactive use is best supported in the form of hydroxyethylrutosides (oxerutins / troxerutin; brand Venoruton) — semi-synthetic derivatives that improve capillary resistance and reduce venous edema.
A meta-analysis of 15 trials found modest improvements in chronic-venous-insufficiency symptoms (swelling, aching, restless legs). The honest caveat: nearly all clinical evidence is for the rutoside DERIVATIVES, not plain dietary rutin, which is far less studied.
Like other venoactives, it relieves symptoms and is an adjunct to compression therapy.
Rutosides strengthen capillary walls and reduce permeability, limiting fluid leakage.
Flavonoid antioxidant activity reduces oxidative/inflammatory venous-wall changes.
How Rutin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Plain rutin at supplement doses is not studied in pregnancy. Small trials of oxerutins (hydroxyethylrutosides), a different compound, found no drug-related problems in late pregnancy, but they cannot establish the safety of plain rutin, and Cochrane reviews say safety is not established. Use only if a clinician advises it. Breastfeeding is not studied.
Flavonoids may have mild antiplatelet activity — theoretical additive effect at high doses.
Tip: Take with food
Tip: Reduce dose
Rutin has an evidence score of 5/10 — moderate evidence based on 67 indexed studies, including 1 meta-analysis. A flavonoid (rutin) whose semi-synthetic derivatives — hydroxyethylrutosides/oxerutins (Venoruton) — have meta-analysis evidence for modestly improving chronic venous insufficiency symptoms. Most evidence is for the rutoside derivative, not plain rutin. Representative study: PMID 25630350.
Dosing for Rutin: Oxerutins (Venoruton) ~1000mg daily; plain rutin products vary widely (a typical label dose, not the dose used in the cited trials, which used 2 g of oxerutins a day). Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Rutin is with meals. Take it with food. Taken with food; consistency over weeks for edema relief.
Rutin is generally well-tolerated and considered safe for most healthy adults at recommended doses. Reported side effects include mild GI upset, headache/flushing. How often they occur is not established for all of them. Use caution if any of these apply to you: Pregnancy/breastfeeding (plain rutin not studied at supplement doses, and the oxerutin pregnancy trials were too small to establish safety); Allergy to rutin/flavonoids.
Aged Garlic Extract
Likely helpsOdorless garlic extract with evidence for blood pressure and cardiovascular markers, and one trial reporting milder colds and flu.
Curcumin
Probably helpsTurmeric's active compound that modulates NF-kB inflammatory pathways — supports mood, joint health, and post-exercise recovery.
Andrographis
Likely helpsStudied for comfort and symptom duration during upper-respiratory infections when taken at onset — also supports liver health.
Ginger Extract
Likely helpsGingerols and shogaols reduce nausea, accelerate gastric emptying, and provide systemic anti-inflammatory benefits.
Explore: Best supplements for Vitality & Longevity
Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 67 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Tap node to isolate • Pinch to zoom • Tap edge for research