1Meta-Analysis2021
Marchi M, Galli G, Magarini FM, Mattei G, Galeazzi GM · Expert Opin Drug Metab Toxicol (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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25 peer-reviewed studies
What the evidence says
Sarcosine doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 2004–2026 with a typical study size of 25 participants.
Based on 25 studies · 3 meta-analyses · 19 RCTs · 25 total participants
Confidence
High confidenceBy outcome
6 studies in the last 5 years · Latest meta-analysis: 2025
Marchi M, Galli G, Magarini FM, Mattei G, Galeazzi GM · Expert Opin Drug Metab Toxicol (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Chang CH, Lin CH, Liu CY, Chen SJ, Lane HY · J Psychopharmacol (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Kałużyńska O, Wysokiński A · Psychiatry Res (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lane HY, Liu YC, Huang CL, Chang YC, Liau CH, Perng CH · Biol Psychiatry (2008)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Podgórski M, Kałużyńska O, Gawlik-Kotelnicka O, Stefańczyk L, Kotlicka-Antczak M · Nutrients (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Tsai CH, Huang HC, Liu BL, Li CI, Lu MK, Chen X · Psychiatry Clin Neurosci (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Podgórski M, Kałużyńska O, Gawlik-Kotelnicka O, Stefańczyk L, Kotlicka-Antczak M · Neurosci Lett (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Tzang RF, Chang YC, Tsai GE, Lane HY · J Psychopharmacol (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lane HY, Chang YC, Liu YC, Chiu CC, Tsai GE · Arch Gen Psychiatry (2005)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Huang CC, Wei IH, Huang CL, Chen KT, Tsai MH, Tsai P · Biol Psychiatry (2013)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lane HY, Huang CL, Wu PL, Liu YC, Chang YC, Lin PY · Biol Psychiatry (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lane HY, Lin CH, Huang YJ, Liao CH, Chang YC, Tsai GE · Int J Neuropsychopharmacol (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Tsai G, Lane HY, Yang P, Chong MY, Lange N · Biol Psychiatry (2004)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Urban-Kowalczyk M, Wysokiński A · Psychiatry Res (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Kałużyńska O, Szyburska J, Wlazło A, Wysokiński A · Psychiatry Res (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Podgórski M, Kałużyńska O, Stefańczyk L, Kotlicka-Antczak M, Gmitrowicz A · Int J Mol Sci (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Kałużyńska O, Szyburska J, Wysokiński A · Int J Mol Sci (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lin CY, Liang SY, Chang YC, Ting SY, Kao CL, Wu YH · World J Biol Psychiatry (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Strzelecki D, Urban-Kowalczyk M, Wysokiński A · Hum Psychopharmacol (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: In this comprehensive overview of clinical trials on pro-cognitive agents in schizophrenia, we identify emerging opportunities but also acknowledge a lack of replicated evidence.
Peyrovian B, Palaniyappan L, Kolivakis TT, Margolese HC. · Acta psychiatrica Scandinavica (2026)