Sch8.5

Schisandra Research

37 peer-reviewed studies · Evidence score: 8.5/10

Treatment of chronic urticaria with traditional Chinese medicine: A systematic review, meta-analysis, and medication regularity

Chen R et al. • Medicine (2025)

TCM has great advantages in the treatment of CU, can effectively improve the symptoms, the curative effect is stable and safe, but there are still some deficiencies in the standardization of curative effect evaluation.

TCM has great advantages in the treatment of CU, can effectively improve the symptoms, the curative effect is stable and safe, but there are still some deficiencies in the standardization of curative effect evaluation.
Further research warranted to confirm findings

Meta-Analysisn=1,192

DOI

Chinese herbal medicine for insomnia: A systematic review and network meta-analysis

Li W et al. • Medicine (2025)

The study provides robust evidence that certain herbal medicines may offer effective and safe alternatives for managing insomnia, potentially reducing the reliance on conventional pharmacological interventions.

The study provides robust evidence that certain herbal medicines may offer effective and safe alternatives for managing insomnia, potentially reducing the reliance on conventional pharmacological interventions.
Further research warranted to confirm findings

Meta-Analysis

DOI

Mechanism, research progress and warning of the effects of acupuncture at Zusanli point (ST36) on pharmacokinetics: A review

Liu X et al. • Medicine (2025)

ST36 acupuncture can alter drug pharmacokinetics, potentially impacting drug exposure and clinical response.

ST36 acupuncture can alter drug pharmacokinetics, potentially impacting drug exposure and clinical response.
Awareness of such interactions is important when combining acupuncture with medication.
Further studies are warranted to ensure the safe and effective integration of acupuncture into pharmacological treatment strategies.

Systematic Review

DOI

Changes in the Gut Microbiota after the Use of Herbal Medicines in Overweight and Obese Individuals: A Systematic Review

Huang M et al. • Nutrients (2023)

Herbal medicine modulates GM and is associated with increased genera in obese individuals.

Herbal medicine modulates GM and is associated with increased genera in obese individuals.
Further research warranted to confirm findings

Systematic Review

DOI

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Wróbel-Biedrawa D et al. • Molecules (Basel, Switzerland) (2024)

Aim: This mini-review aims to present the anti-neuroinflammatory potential of the most important plants classified as adaptogens: Schisandra chinensis, Eleutherococcus senticosus, Rhodiola rosea and Withania somnifera.

Because of the specific nature of the brain, this process is called neuroinflammation, and its suppression can result in an improvement of patients' condition and may promote their recovery.
Adaptogens as anti-inflammatory agents: As has been discovered, adaptogens display anti-inflammatory effects, which suggests that their application may be broader than previously thought.
They regulate gene expression of anti- and proinflammatory cytokines (prostaglandins, leukotriens) and can modulate signaling pathways (e.g., NF-κB).

Systematic Review

DOI

Extraction, purification, structural characterization, and biological activity of polysaccharides from Schisandra chinensis: A review

Ji R et al. • International journal of biological macromolecules (2024)

SCPs are mainly composed of glucose, mannose, rhamnose, galactose, galacturonic acid and arabinose.

SCPs are mainly composed of glucose, mannose, rhamnose, galactose, galacturonic acid and arabinose.
This article aims to provide a systematic review of the research progress in the extraction and separation methods, structural characterization, and biological activity of SCPs both domestically and internationally in recent years.
This deeply explores the pharmacological activity and action mechanism of SCPs, and provides a certain point of reference for the research and clinical application of SC.Copyright © 2024 Elsevier B.V.

Systematic Review

DOI

Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance

Chan WJ et al. • Cancer chemotherapy and pharmacology (2023)

This systematic-review examined the effects of Schisandra.

Clinical studies investigating pharmacokinetic interactions provide evidence that negative treatment outcomes may occur when Hypericum perforatum, Grapefruit, Schisandra sphenanthera, Curcuma longa or Hydrastis canadensis are taken concurrently with common cancer treatments.
Conversely, pharmacodynamic interactions between Hangeshashinto (TJ-14) and some cancer treatments have been shown to reduce the side effects of diarrhoea and oral mucositis.
In summary, research in this area is limited and requires further investigation.

Systematic Review

DOI

Plant Adaptogens-History and Future Perspectives

Todorova V et al. • Nutrients (2021)

In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body's resistance to stress and to improve physical endurance.
Although now many people take plant adaptogens, the clinical trials on human are limited.
The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection.

Meta-Analysis

DOI

A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview

Maideen NMP et al. • Current drug metabolism (2021)

The prescribers and the pharmacists are needed to be aware of the drugs interacting with β-blockers to prevent possible adverse drug interactions.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

John's wort and Yohimbine.
This article focuses on clinically relevant drug interactions of β-blockers with commonly prescribed medications.
In addition to Pharmacokinetics and Pharmacodynamics of the drug interactions, recommendations for clinical practice are highlighted.

Systematic Review

DOI

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Pferschy-Wenzig EM et al. • Nutrients (2022)

Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways.

Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways.
However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites.
Data for Panax ginseng, Schisandra chinensis, and Salvia rosmarinus indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits.

Systematic Review

DOI

Tacrolimus and herbs interactions: a review

Abushammala I • Die Pharmazie (2021)

Furthermore, patients who are already undergoing TAC treatment should be informed about the possibility of dangerous interactions between herbal remedies and TAC.

TAC's interactions with herbal extracts are reviewed here, because with more people using TAC, it is becoming crucial to know which extracts, which are often part of self-medication, can alter TAC blood concentrations.
Thus, physicians and pharmacists should thoroughly educate their patients regarding the use of supplemental herbs before administering TAC.
Furthermore, patients who are already undergoing TAC treatment should be informed about the possibility of dangerous interactions between herbal remedies and TAC.

Systematic Review

DOI

Schisandra sphenanthera: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications

Huang S et al. • The American journal of Chinese medicine (2021)

This review systematically summarized literatures on the botany, phytochemistry, pharmacology, development utilization, and clinical application of S. sphenanthera, in hopes of provide a useful reference for researchers for further studies of this plant.

In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly obtained from the fruits and stems of S. sphenanthera.
Pharmocological studies have shown that the extracts and monomeric compounds of S. sphenanthera possessed wide-range bioactivities, such as antitumor, anti-oxidant, anti-inflammatory, osteoblastic, immune regulation, neuroprotective, kidney protection, hepatoprotective, and antiviral activities.
However, resource availability, quality control measures, in-depth in vivo pharmacological study, and clinical application are still insufficient and deserve further studies.

Systematic Review

DOI

Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review

Zhou Y et al. • European journal of pharmacology (2021)

Additionally, some of these lignans also showed certain potentials in anti-cancer, anti-fibrosis, and other effects.

Additionally, some of these lignans also showed certain potentials in anti-cancer, anti-fibrosis, and other effects.
In the current review, we summarize literature reported lignans from S. chinensis in the past five years, and highlight the molecular mechanisms of lignans in exerting their biological functions.
Also, we point out some deficiencies of existing researches and discuss the future direction of lignans study.Copyright © 2020 Elsevier B.V.

Systematic Review

DOI

A Comprehensive Review on Schisandrin B and Its Biological Properties

Nasser MI et al. • Oxidative medicine and cellular longevity (2020)

This systematic-review examined the effects of Schisandra.

The data suggest that the antitumor activities of Sch B were mainly through apoptosis and cell cycle arrest at the diver's stage.
Further research warranted to confirm findings

Systematic Review

DOI

Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives

Nowak A et al. • Nutrients (2019)

First, the constituents responsible for its beneficial effects should be isolated and identified, and recommended as preventative nutritional additives, or considered as therapeutics.

In food technology, SCE is applied as a preservative, and as an additive to increase the flavour, taste, and nutritional value of food.
In summary, SCE displays a variety of beneficial health effects, with no side effects.
Further research is needed to determine the molecular mechanisms of SCE action.

Systematic Review

DOI

Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease

Leong PK et al. • Oxidative medicine and cellular longevity (2016)

The optimal dose and duration of Sch B treatment need to be established in order to ensure maximal efficacy and safety when used in humans.

This differential action of Sch B is likely related to a dose/time-dependent biphasic response on lipid metabolism in mice.
The hepatoprotection afforded by Sch B against oxidative stress, ER stress, and inflammation has been widely reported.
The ensemble of results suggests that Sch B may offer potential as a therapeutic agent for NAFLD.

Systematic Review

DOI

Interactions between clopidogrel and traditional Chinese medicine

Hu Y et al. • Journal of thrombosis and thrombolysis (2019)

With more awareness and understanding on potential drug-herb interactions of clopidogrel and TCM, it may be possible to combine clopidogrel with TCM herbs to yield a better therapeutic outcome.

Additionally, Schisandra chinensis, Danggui, Gegen and Fufang Danshen Dripping Pill can decrease the AUC or Cmax of the clopidogrel inactive metabolite, while Curcumin on the contrary.
The pharmacodynamics of Panax notoginseng, Notoginsenoside Ft1, Hypericum perforatum, Shexiang baoxin pills, Naoxintong capsule increased the antiplatelet activity compared with clopidogrel alone, while Danshen decreased the platelet inhibition.
In adverse reactions, Danggui can enhance the adverse effects of clopidogrel on the bleeding time.

Systematic Review

DOI

Adaptogens in mental and behavioral disorders

Panossian AG • The Psychiatric clinics of North America (2013)

This article focuses on the most extensively studied adaptogens: Rhodiola rosea, Eleutherococcus senticosus, and Schisandra chinensis.

This article focuses on the most extensively studied adaptogens: Rhodiola rosea, Eleutherococcus senticosus, and Schisandra chinensis.
Clinical studies, evidence for stress-protective and simulative effects, and molecular mechanisms of action on metabolic and other processes regulated by the neuroendocrine system are discussed.

Systematic Review

DOI

Effect of Saengmaeksan on Fatigue, Liver Function, and Immunity Combined with High-Intensity Training

Juan S et al. • Journal of immunology research (2023)

These findings demonstrate that SMS intake can reduce ammonia, AST, ALT, and IgM levels, while causing an increase in IgA, which has a positive effect on fatigue reduction, liver function, and immunoglobulins in a high-intensity training or related environment.

High-intensity training was performed at 70%-90% of heart rate reserve, conducted five times weekly for 4 weeks.
Ammonia levels significantly decreased in the SMS group, but there was no difference in the lactic acid levels.
AST significantly decreased in the SMS group.

RCTn=770

DOI

Efficacy and Safety of Omija (Schisandra chinensis) Extract Mixture on the Improvement of Hyperglycemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial

Kim DS et al. • Nutrients (2022)

Therefore, it is hypothesized that OSM supplementation is an effective and safe functional food supplement for humans with hyperglycemia.

After the intervention, the OSM group showed significantly decreased levels of FPG, PPG (30, 60 min), PPI (60 min), insulin area under the curve (AUC), fructosamine, and low-density-lipoprotein (LDL) cholesterol compared to the placebo group.
The outcomes included measurements of efficacy (fasting plasma glucose (FPG), postprandial glucose (PPG), fasting plasma insulin (FPI), postprandial insulin (PPI), hemoglobin A1c (HbA1c), C-peptide, fructosamine, and lipid parameters) and safety at baseline and at 12 weeks.
No clinically significant changes in any safety parameter were observed.

RCTn=80

DOI

Page 1 of 2

View in Research Library