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Serrapeptase (Serratiopeptidase)
Silkworm-derived enzyme that breaks down inflammatory proteins and thins mucus — used in Europe and Japan as an NSAID alternative.
What the evidence says
Most Serrapeptase studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2013–2026 with a typical study size of 90 participants.
Based on 10 studies · 1 meta-analysis · 2 RCTs · 571 total participants
Confidence
ModerateBy outcome
Serrapeptase has an evidence score of 7/10 — strong evidence based on 10 indexed studies. Silkworm-derived enzyme that breaks down inflammatory proteins and thins mucus — used in Europe and Japan as an NSAID alternative.
The commonly studied dose of Serrapeptase is 120,000-240,000 SPU (serrapeptase units). Research points to an estimated optimal dose around 240000SPU, with a minimum effective dose near 120000SPU. Individual response varies — start low and adjust.
The best time to take Serrapeptase is between meals. It can be taken on an empty stomach. Serrapeptase (serratiopeptidase) is a proteolytic enzyme originally isolated from Serratia marcescens in silkworm intestines.
Bromelain
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Last reviewed May 2026 · evidence from 17 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Serrapeptase is a proteolytic enzyme originally isolated from the silkworm. It breaks down proteins involved in inflammation and scar tissue, and may help thin mucus. Popular in Europe and Japan for post-surgical recovery, sinusitis, and inflammatory conditions. Used as an alternative to NSAIDs for pain and swelling.
Breaks down inflammatory proteins
Thins and clears mucus
How Serrapeptase works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
120,000-240,000 SPU (serrapeptase units)
Can be taken without food
| Form | Type |
|---|---|
| 💊Enteric-coated capsules (protects from stomach acid) | Recommended |
| 💊Delayed-release tablets | Alternative |
Enteric coating is essential — stomach acid destroys unprotected serrapeptase.
Minimum: 2 weeks
Optimal: 4 weeks
Cycling: Not required
Note: MUST be taken on empty stomach for systemic effects. Food inactivates the enzyme.
Based on 3 RCTs in dental surgery patients. Effects were modest and one study showed dexamethasone was superior. Requires enteric-coated formulation for bioavailability.
Less edema and inflammation
Improved mucus drainage
Insufficient data; avoid
May increase bleeding risk
May increase antibiotic tissue levels
Tip: Use enteric-coated; take on empty stomach
Tip: Discontinue if rash develops
Serrapeptase is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are GI upset, skin reactions. Use caution if any of these apply to you: Bleeding disorders; Before surgery (stop 2 weeks prior).
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