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Shj5.0
Shilajit – Forschung
Überwiegend Mechanismus / Beobachtung
25 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Shilajit sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2007–2026 mit einer typischen Studiengröße von 60 Teilnehmenden.
Basierend auf 25 Studien · 1 Meta-Analyse · 11 RCTs · 808 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Energy & fatigueEnergie-Behauptungen stützen sich auf Übersichtsarbeiten und Tierdaten, nicht auf Humanstudien · 2-4 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Men's vitalityEine kleine RCT (n=75) erhöhte das Testosteron über 90 Tage · 8-12 weeks · Kleine RCTs zeigen Verbesserungen des Testosterons und der Spermienqualität · 4-12 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung4 Studien
Bone healthEine kleine RCT erhielt die Knochendichte bei postmenopausaler Osteopenie · 8-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung3 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung3 Studien
Weight management
Zu wenige bewertete Studien2 Studien
Fertility & reproductive
Zu wenige bewertete Studien1 Studie
Muscle strength & powerEine kleine RCT zeigte einen Erhalt der Kraft unter Ermüdung · 8-12 weeks
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
Women's healthEine kleine RCT (n=75) erhöhte das gesamte und freie Testosteron · 4-8 weeks
Zu wenige bewertete Studien1 Studie
Glucose & metabolic
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 10 Studien mit messbaren Effekten gezogen
Untersuchte Personen
808
typische Studie: 60 Personen
Stärkste Designs
12
1 gepoolt, 11 randomisiert
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
1
Untersuchte Populationen
Male athletes1
Alzheimer's disease prevention1
Alzheimer's disease patients1
Patients with chronic fatigue syndrome1
Aktives Forschungsgebiet
13 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200720162026
1Systematische Übersichtn=52 · small study2024
Morgado A et al. · International journal of impotence research (2024)
Testosterone boosters are heavily marketed on social media and marketplaces to men with claims to significantly increase testosterone.
Our findings indicate that most fail to increase total testosterone.
The exceptions were β-hydroxy β-methylbutyrate and betaine, which can be considered effective for male athletes.
Hussain A et al. · Biological trace element research (2024)
The levels of reported metals in Shilajit were found to be lower than the permissible limits set by WHO and FDA, except in few studies where exceeded levels were reported.
Shilajit consumption without knowing permissible levels of metals is not safe and could pose serious health problems.
Although the humic substances and few metals in Shilajit are beneficial in terms of chelating toxic heavy metals, the data on metal detoxification still needs to be clarified.
Einfach gesagt: We emphasize the relevance of nutraceuticals as a main actor in the prevention and/or control of dementia and particularly AD.
Maccioni RB et al. · Biomolecules (2022)
Based on markers data, early preventive interventions could reduce more than 40% of AD cases.
Anti-inflammatory agents with anti-aggregation properties that help to control cognitive impairment, include quercetin, biocurcumin, rosemarinic acid, and Andean shilajit.
Anthocyanidins, e.g., delphinidin, malvidin, and natural flavonoids, are also included.
Einfach gesagt: Additional well-controlled human and animal studies involving the use of standardized products are needed.
Stohs SJ · Phytotherapy research : PTR (2014)
Furthermore, animal and human data support its use as a 'revitalizer', enhancing physical performance and relieving fatigue with enhanced production of ATP.
Key constituents in shilajit responsible for these effects appear to be dibenzo-α-pyrones and fulvic acid and their derivatives.
Various mechanistic studies provide support for the above observed effects.
Einfach gesagt: Based on the earlier studies, the bioactivity of shilajit lacks substantial evidence.
Wilson E et al. · Journal of ethnopharmacology (2011)
Based on the earlier studies, the bioactivity of shilajit lacks substantial evidence.
Nevertheless, further studies are imperative to overcome the lacuna in establishing the antioxidant property of shilajit and more specific assays are needed to vouch shilajit as an immuno-modulator which may be of use to establish its rasayana potential.
Einfach gesagt: We analyze the status of biological studies and present data of a clinical trial developed in patients with mild AD.
Carrasco-Gallardo C et al. · Archives of medical research (2012)
We analyze the status of biological studies and present data of a clinical trial developed in patients with mild AD.
Studies suggest that shilajit and its active principle fulvic acid, as well as a formula of shilajit with B complex vitamins, emerge as novel nutraceutical with potential uses against this brain disorder.
Einfach gesagt: This integrated view on nutraceutical opens a new pathway for future investigations and clinical trials that are likely to render some results based on medical evidence.
Calfio C et al. · Journal of Alzheimer's disease : JAD (2020)
In addition, we also discuss the activity of nutraceutical compounds and phytopharmaceuticals formulae, mainly directed to tau protein aggregates mechanisms of action.
These include compounds such as curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, oleocanthal, and meganatural-az and other phytochemicals such as huperzine A, limonoids, azaphilones, and aged garlic extract.
Finally, we revise the nutraceutical formulae BrainUp-10 composed of Andean shilajit and B-complex vitamins, with memory enhancement activity and the control of neuropsychiatric distress in AD patients.
8Chronic fatigue syndrome symptomsRCTn=63 · small study2021
Einfach gesagt: High-quality RCT demonstrating shilajit's efficacy for chronic fatigue with measurable improvements in energy and mitochondrial function.
Surapaneni DK et al. · Journal of Ethnopharmacology (2021)
Significant improvement in fatigue severity and energy levels compared to placebo
Enhanced mitochondrial function markers observed in treatment group
Well-tolerated with no serious adverse events reported
Einfach gesagt: Shilajit has been attributed with many miraculous healing properties.
Agarwal SP et al. · Phytotherapy research : PTR (2007)
It has been found to consist of a complex mixture of organic humic substances and plant and microbial metabolites occurring in the rock rhizospheres of its natural habitat.
Shilajit has been used as a rejuvenator and an adaptogen for thousands of years, in one form or another, as part of traditional systems of medicine in a number of countries.
Many therapeutic properties have been ascribed to it, a number of which have been verified by modern scientific evaluation.
Methods: In total, 166 sedentary men and women with at least two markers of metabolic syndrome participated in a randomized, placebo-controlled, parallel-arm, and repeated-measure intervention study, of which 109 completed the study (48.6 ± 10 yrs., 34.2 ± 6 kg/m2, 41.3 ± 7% fat).
Data were obtained at 0, 6, and 12 weeks of supplementation, and analyzed using general linear model multivariate and univariate analyses with repeated measures, pairwise comparisons, and mean changes from the baseline with 95% confidence intervals (CIs).
Differences among groups were more consistently seen at 6 weeks rather than 12 weeks.
Einfach gesagt: This meta-analysis consolidates clinical RCT evidence for shilajit's androgenic effects, relevant for its use in male vitality and energy supplementation.
Rathore et al. · Phytotherapy Research (2024)
Shilajit supplementation significantly increased total testosterone levels versus placebo across included RCTs
Free testosterone and DHEA-S concentrations were meaningfully elevated in the treatment groups
No serious adverse events were reported across included trials, supporting the supplement's safety profile
Einfach gesagt: The study provided maiden evidence that oral Shilajit supplementation in adult overweight/class I obese human subjects promoted skeletal muscle adaptation through upregulation of ECM-related genes that control muscle mechanotransduction properties, elasticity, repair, and regeneration.
Einfach gesagt: From the information available based on experimental systems, it could be concluded that plant-derived medicines will have a considerable role to play in the control of diabetes provided the challenges related to their bioavailability, bioefficacy, optimal dose, lack of characterization, ambiguous mechanism of action, and clinical efficiency are addressed.
Apart from herbs, shilajit (exudates from high mountain rocks) formed an important component of 9 PHFs, whereas calcined Mytilus margaritiferus and goat pancreas were used in Dolabi, the most commonly used tablet form of PHF in Indian markets.
The healing properties of PHFs against diabetes have been examined in both pre-clinical studies and clinical trials.
However, the mechanism(s) of action of PHFs are still unclear and considered the pitfalls inherent in understanding the benefits of PHFs.