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3 peer-reviewed studies
What the evidence says
Most Sulbutiamine studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 1999–2020 with a typical study size of 315 participants.
Based on 3 studies · 1 RCT · 341 total participants
Confidence
LowBy outcome
Newest study from 2020
A randomized, double-blind trial (n=315) tested sulbutiamine for chronic post-infectious fatigue, with mixed/modest results.
Tiev KP et al. · Rev Med Interne (1999)
A review summarized the synthetic vitamin B1 derivative sulbutiamine and its proposed effects on fatigue, memory, and mood.
Starling-Soares B et al. · J Nutr Metab (2020)
A clinical study reported sulbutiamine reduced fatigue in a patient group.
Sevim S et al. · Mult Scler Relat Disord (2017)