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Tc5.5
Theacrine – Forschung
Überwiegend Mechanismus / Beobachtung
13 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Theacrine sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 2015–2026 mit einer typischen Studiengröße von 20 Teilnehmenden.
Basierend auf 13 Studien · 12 RCTs · 205 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Endurance & exercise performanceAusdauernutzen nicht belegt — die meisten RCTs mit Theacrine allein zeigten keine Verbesserung · 30-60 minutes · Eigenständige ergogene Wirkung nicht nachgewiesen; kann Koffein ergänzen · 30-60 minutes
Überwiegend Mechanismus / Beobachtung9 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung6 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung4 Studien
Energy & fatigueAnhaltende Energie ohne Toleranzentwicklung · 30-60 minutes
Depression & moodVerbesserte Stimmung über den Dopamin-Signalweg · 30-60 minutes
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
7 Studien in den letzten 5 Jahren
201520202026
1Effects on depression, anxiety, and sleep disordersSystematische Übersicht2024
Einfach gesagt: The underlying molecular mechanisms involve the regulation of neurotransmitters, including monoamines, GABA, and brain-derived neurotrophic factor (BDNF), as well as the suppression of oxidative st...
Han Z et al. · Food research international (Ottawa, Ont.) (2024)
The underlying molecular mechanisms involve the regulation of neurotransmitters, including monoamines, GABA, and brain-derived neurotrophic factor (BDNF), as well as the suppression of oxidative stress and inflammation.
Additionally, these ingredients may influence the microbiota-gut-brain (MGB) axis and the hypothalamic-pituitary-adrenal (HPA) axis.
Einfach gesagt: These findings suggest similar benefits on RT during a vigilance task between CAF, containing 300 mg caffeine, and CMT above PLA, though CAF resulted in slightly less favorable hemodynamic changes.
Cintineo HP et al. · Journal of the International Society of Sports Nutrition (2022)
These findings suggest similar benefits on RT during a vigilance task between CAF, containing 300 mg caffeine, and CMT above PLA, though CAF resulted in slightly less favorable hemodynamic changes.
This study is the first to provide data showing similar efficacy of combined caffeine, methylliberine, and theacrine compared to double the caffeine dose consumed alone on vigilance RT but without a significant rise in DBP above PLA in tactical personnel.
Einfach gesagt: SIngestion of CAF and CTC improved various measures of cognitive performance before, and after fatiguing exercise.
Lints BS et al. · Journal of the International Society of Sports Nutrition (2025)
In the Object Hit & Avoid task, CAF and CTC significantly improved task accuracy (p < 0.01) while reducing omission (p < 0.01) and commission errors (p < 0.01) compared to PLA.
HRV measures (RMSSD, NN intervals, SDNN) significantly increased post-supplementation (p < 0.01) but decreased immediately (p < 0.01) and 30 min post-exercise (p < 0.01).
SIngestion of CAF and CTC improved various measures of cognitive performance before, and after fatiguing exercise.
Einfach gesagt: In conclusion, theacrine supplementation does not improve endurance performance and provokes side effects that might restrict its use as a supplement.
Vieira-Cavalcante V et al. · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme (2025)
No significant differences (p < 0.05) were observed in time to cover the 4 km cycling time trial between the placebo, 3 mg·kg-1 of theacrine, and 6 mg·kg-1 of theacrine conditions.
However, the intake of theacrine at the dose of 6 mg·kg-1 increased resting systolic and diastolic blood pressure (p < 0.05).
Some side effects, such as gastrointestinal discomfort, perception of tachycardia, dizziness, headache, head pressure, hand tremor, and lack of disposition were reported after the ingestion of either 3 or 6 mg·kg-1 of body mass of theacrine.
Einfach gesagt: Therefore, the findings of this study do not support the use of theacrine to increase physical performance.
Cerqueira HSC et al. · International journal of environmental research and public health (2022)
The first assessment served as a basal measurement.
In the second, the subjects ingested the supplement or a placebo 60 min before the following tests: sextuple jump, agility T test, 30 m sprint, 40 s run test (Matsudo test), and 12 min run test (Cooper test).
There was no difference between the groups in any of the tests.
Einfach gesagt: The 27-38% improvements in TTE reflect increased performance capacity that may have important implications for overtime scenarios.
Bello ML et al. · Journal of the International Society of Sports Nutrition (2019)
The 27-38% improvements in TTE reflect increased performance capacity that may have important implications for overtime scenarios.
These findings suggest TeaCrine® favorably impacts endurance and the combination with caffeine provides greater benefits on cognitive function than either supplement independently.
Einfach gesagt: In conclusion, our findings suggest that MIES can increase cerebral-cortical activation and RT during task performance while increasing sensitivity to target stimuli in a dose-dependent manner.
Daou M et al. · Journal of dietary supplements (2019)
For both d' and RT, the Session (MIES-1, MIES-2, PL) × Time (pretest, posttest) interaction approached statistical significance (p = .07, η2p = 0.106).
With respect to upper-alpha power, the Session × Time interaction was significant (p < .001, η2p = 0.422).
Exploring these interactions with linear contrasts, a significant linear effect of supplement dose on the linear effect of time was observed (ps ≤.034), suggesting the pretest-to-posttest improvement in sensitivity to task target stimuli (d') and RT increased as a function of supplement dose.
Einfach gesagt: Neither TEA300, CAFF300, COMBO, or PLA (when consumed 90 min pre-exercise) improved muscular strength, power, or endurance performance in resistance-trained men.
Cesareo KR et al. · Journal of the International Society of Sports Nutrition (2019)
Only CAFF300 resulted in significant increases in perceived energy and motivation to exercise vs.
TEA300, but there were no significant differences between CAFF300 and COMBO (Energy + 3.9% [- 6.9-14.7%], Focus + 2.5% [- 6.3-11.3%], Motivation to exercise + 0.5% [- 11.6-12.6%]; p > 0.05).
Neither TEA300, CAFF300, COMBO, or PLA (when consumed 90 min pre-exercise) improved muscular strength, power, or endurance performance in resistance-trained men.
Einfach gesagt: These data indicate that TheaTrim treatment does not result in a statistically significant improvement in cognitive performance but may favorably impact multiple subjective feelings related to energy and mood.
Kuhman DJ et al. · Nutrients (2015)
These data indicate that TheaTrim treatment does not result in a statistically significant improvement in cognitive performance but may favorably impact multiple subjective feelings related to energy and mood.
No condition or interaction effects were noted for TMT, DSST, or reaction time, despite a trend for improvement in selected variables with both TheaTrim and caffeine treatment.
Condition effects or trends were noted for subjective feelings, with values for attentive, alert, focused, and energetic higher for TheaTrim than for placebo and caffeine, while values for lethargic and groggy were lower for TheaTrim than for placebo and caffeine.
Stoke C et al. · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme (2026)
Repeated measures ANOVA results indicated greater salivary cortisol concentration in the theacrine conditions versus the placebo condition at 120 and 180 min post-treatment.
The effect of greater theacrine doses on subjective feelings of energy is unclear, as energy only improved in the placebo treatment.
Overall, greater theacrine doses increased salivary cortisol with no significant impacts on heart rate, blood pressure, subjective feelings of energy, alpha-amylase, and cognitive performance.