1Meta-AnalysisCited 24×2020
Zuo S, Wang G, Han Q, Xiao H, O Santos H, Avelar Rodriguez D · Complement Ther Med (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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65 peer-reviewed studies
What the evidence says
Tocotrienols doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 2002–2026 with a typical study size of 71 participants.
Based on 65 studies · 6 meta-analyses · 41 RCTs · 71 total participants
Confidence
High confidenceBy outcome
31 studies in the last 5 years · Latest meta-analysis: 2024
Zuo S, Wang G, Han Q, Xiao H, O Santos H, Avelar Rodriguez D · Complement Ther Med (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Khor BH, Tiong HC, Tan SC, Wong SK, Chin KY, Karupaiah T · PLoS One (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Phang SCW, Ahmad B, Abdul Kadir K, M Palanisamy UD · Adv Nutr (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Li F, Xu B, Soltanieh S, Zanghelini F, Abu-Zaid A, Sun J · Crit Rev Food Sci Nutr (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Violi F, Nocella C, Loffredo L, Carnevale R, Pignatelli P · Free Radic Biol Med (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: However, with heterogeneous outcomes from pre-clinical studies and a lack of clinical studies, the translatability of data to the effect of chronic consumption on cerebrovascular function in humans is limited.
Jansen S, Graham CJ, Mills DE, Bliss ES. · Nutritional neuroscience (2026)
Georgousopoulou EN, Panagiotakos DB, Mellor DD, Naumovski N · Maturitas (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ismail M, Alsalahi A, Imam MU, Ooi J, Khaza'ai H, Aljaberi MA · Nutrients (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Nasir NAA, Sadikan MZ, Agarwal R · Asia Pac J Clin Nutr (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Radzi NFM, Ismail NAS, Alias E · Curr Drug Targets (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: This review highlights the multifaceted roles of vitamin E in brain health and underscores the urgent need for well-designed studies to clarify the distinct and synergistic effects of tocopherols and tocotrienols, particularly in human populations.
Razali RA, Ngah WZW, Makpol S, Yanagisawa D, Kato T, Tooyama I. · International journal of molecular sciences (2025)
Sharif M, Khan DA, Farhat K, Noor M, Khan MA, Rafique S · J Pak Med Assoc (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mohseni S, Tabatabaei-Malazy O, Ejtahed HS, Qorbani M, Azadbakht L, Khashayar P · Daru (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Retzlaff D, Dörfler J, Kutschan S, Freuding M, Büntzel J, Hübner J · Nutr Cancer (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: The convergence of these neuroprotective effects suggests that TRF holds potential as a supplement to support healthy ageing or, at the very least, slow neurodegeneration by mitigating pathological changes that often begin insidiously before the onset of symptoms associated with cognitive decline.
Yunita E, Nasaruddin ML, Ramli NZ, Yahaya MF, Ahmad Damanhuri H. · International journal of molecular sciences (2025)
Raunkilde L, Hansen TF, Havelund BM, Thomsen CB, Rafaelsen SR, Lindebjerg J · Acta Oncol (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Shen CL, Mo H, Yang S, Wang S, Felton CK, Tomison MD · BMJ Open (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mustad VA, Smith CA, Ruey PP, Edens NK, DeMichele SJ · Am J Clin Nutr (2002)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ng YT, Phang SCW, Tan GCJ, Ng EY, Botross Henien NP, M Palanisamy UD · Nutrients (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rasool AH, Rahman AR, Yuen KH, Wong AR · Arch Pharm Res (2008)
No plain-language summary recorded for this citation — open the paper to read its abstract.