Tocotrienols Research

The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials.

Zuo S, Wang G, Han Q, Xiao H, O Santos H, Avelar Rodriguez D · Complement Ther Med (2020)

Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

Khor BH, Tiong HC, Tan SC, Wong SK, Chin KY, Karupaiah T · PLoS One (2021)

Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Phang SCW, Ahmad B, Abdul Kadir K, M Palanisamy UD · Adv Nutr (2023)

The effects of tocotrienols intake on obesity, blood pressure, inflammation, liver and glucose biomarkers: a meta-analysis of randomized controlled trials.

Li F, Xu B, Soltanieh S, Zanghelini F, Abu-Zaid A, Sun J · Crit Rev Food Sci Nutr (2022)

Interventional study with vitamin E in cardiovascular disease and meta-analysis.

Violi F, Nocella C, Loffredo L, Carnevale R, Pignatelli P · Free Radic Biol Med (2022)

Effect of vitamin E on cerebrovascular function: a systematic review

In plain English: Future well-designed studies in older adults are warranted to determine whether vitamin E supplementation can preserve or improve cerebrovascular function throughout the ageing process.

Jansen S, Graham CJ, Mills DE, Bliss ES. · Nutritional neuroscience (2026)

Tocotrienols, health and ageing: A systematic review.

Georgousopoulou EN, Panagiotakos DB, Mellor DD, Naumovski N · Maturitas (2017)

Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review.

Ismail M, Alsalahi A, Imam MU, Ooi J, Khaza'ai H, Aljaberi MA · Nutrients (2020)

Modulation of NFκB signalling pathway by tocotrienol: A systematic review.

Nasir NAA, Sadikan MZ, Agarwal R · Asia Pac J Clin Nutr (2021)

Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review.

Radzi NFM, Ismail NAS, Alias E · Curr Drug Targets (2018)

Shifting Perspectives on the Role of Tocotrienol vs. Tocopherol in Brain Health: A Scoping Review

In plain English: This review highlights the multifaceted roles of vitamin E in brain health and underscores the urgent need for well-designed studies to clarify the distinct and synergistic effects of tocopherols and tocotrienols, particularly in human populations.

Razali RA, Ngah WZW, Makpol S, Yanagisawa D, Kato T, Tooyama I. · International journal of molecular sciences (2025)

Pharmacokinetics and bioavailability of tocotrienols in healthy human volunteers: a systematic review.

Sharif M, Khan DA, Farhat K, Noor M, Khan MA, Rafique S · J Pak Med Assoc (2023)

Effect of vitamins C and E on cancer survival; a systematic review.

Mohseni S, Tabatabaei-Malazy O, Ejtahed HS, Qorbani M, Azadbakht L, Khashayar P · Daru (2022)

The Vitamin E Isoform α-Tocopherol is Not Effective as a Complementary Treatment in Cancer Treatment: A Systematic Review.

Retzlaff D, Dörfler J, Kutschan S, Freuding M, Büntzel J, Hübner J · Nutr Cancer (2022)

Scoping Review: The Role of Tocotrienol-Rich Fraction as a Potent Neuroprotective Agent

In plain English: The convergence of these neuroprotective effects suggests that TRF holds potential as a supplement to support healthy ageing or, at the very least, slow neurodegeneration by mitigating pathological changes that often begin insidiously before the onset of symptoms associated with cognitive decline.

Yunita E, Nasaruddin ML, Ramli NZ, Yahaya MF, Ahmad Damanhuri H. · International journal of molecular sciences (2025)

Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study.

Raunkilde L, Hansen TF, Havelund BM, Thomsen CB, Rafaelsen SR, Lindebjerg J · Acta Oncol (2023)

Safety and efficacy of tocotrienol supplementation for bone health in postmenopausal women: protocol for a dose-response double-blinded placebo-controlled randomised trial.

Shen CL, Mo H, Yang S, Wang S, Felton CK, Tomison MD · BMJ Open (2016)

Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia.

Mustad VA, Smith CA, Ruey PP, Edens NK, DeMichele SJ · Am J Clin Nutr (2002)

The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial.

Ng YT, Phang SCW, Tan GCJ, Ng EY, Botross Henien NP, M Palanisamy UD · Nutrients (2020)

Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E.

Rasool AH, Rahman AR, Yuen KH, Wong AR · Arch Pharm Res (2008)