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Tka6.0
Tongkat Ali Research
Probably helps
19 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Tongkat Ali studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2010–2024 with a typical study size of 84 participants.
Based on 19 studies · 2 meta-analyses · 7 RCTs · 668 total participants
Confidence
High confidence
What the studies found
1helped1unclear· 17 more without graded effect data
By outcome
Men's vitalityIncreased free testosterone, improved libido · 2-4 weeks · Reduces SHBG and cortisol to improve testosterone-to-cortisol ratio · 4-8 weeks
Mostly mechanism / observational14 studies
Energy & fatigueImproved energy and vitality · 2-4 weeks
Mostly mechanism / observational4 studies
Muscle strength & powerMay increase testosterone, especially if low or stressed · 4-12 weeks
2Traditional Chinese medicine properties analysisSystematic Review2024
In plain English: This study aims to facilitate the compatible use and product development of Tongkat Ali while providing reference for introducing it as a new TCM resource and studying the TCM properties of ginseng plants abroad.
Ye DN et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2024)
Tongkat Ali has the main functions of tonifying kidney and replenishing essence, invigorating spleen and replenishing Qi, and soothing liver and relieving depression.
The recommended dosage and usage of this medicine are 2-10 g daily and decoction with water, respectively.
This study aims to facilitate the compatible use and product development of Tongkat Ali while providing reference for introducing it as a new TCM resource and studying the TCM properties of ginseng plants abroad.
3Erectile function (IIEF-5 score)Meta-Analysisn=139 · medium study2015
In plain English: Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function.
Kotirum S et al. · Complementary therapies in medicine (2015)
No clear effect
← WorseNo effectBetter →
Likely real
No significance between group difference was found in the mean WMD of the change in the 5- item version of the international index of erectile function (IIEF-5) at week-12 (0.91; 95% CI: -1.50 to 3.33 with I(2)=89.5%, P-value=0.002) with statistical heterogeneity.
Based on the subgroup analysis, significant improved IIEF-5 score of 2.15 (95% CI 1.03-3.27) was found in subjects with lower baseline IIEF-5 score, but this was not seen among those with higher baseline IIEF-5 score.
Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function.
4Traditional uses, chemistry, pharmacology and toxicologyReview2016
In plain English: Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia.
Rehman SU et al. · Molecules (2016)
The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids and β-carboline alkaloids, with quassinoids accounting for a major portion of the root phytochemicals.
An acute toxicity study found the oral LD50 of the alcoholic extract in mice is between 1500-2000 mg/kg, while the aqueous extract LD50 is more than 3000 mg/kg.
Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia.
5Male sexual health improvementSystematic Review2017
In plain English: In summary, there is convincing evidence for the prominence of EL in improving the male sexual health.
Thu HE et al. · Chinese journal of natural medicines (2017)
In summary, there is convincing evidence for the prominence of EL in improving the male sexual health.
The review also substantiates the use of current methodology in the development of novel and more rationale natural herbal medicines for the management of male sexual disorders.
In plain English: Therefore, TA might be a safe alternative to TRT.
George A et al. · Andrologia (2014)
The testosterone deficiency syndrome (TDS) is characterised by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males' symptoms.
This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40-50% lower in men older than 60 years compared with young men.
Eurycoma longifolia (Tongkat Ali; TA) is natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health.
7Erectile dysfunction supplement efficacySystematic Reviewn=21 · very small study2019
In plain English: Our investigation revealed that human studies evaluating the efficacy of ED-S ingredients are limited and have yielded no definitive findings of the effects on ED.
Balasubramanian A et al. · The journal of sexual medicine (2019)
Our literature review identified 413 studies involving the 21 identified ingredients, of which 59 (16%) involved human subjects.
Among these 69 human studies, only 12 (17%) investigated supplement ingredients individually and reported improvement in ED.
Our investigation revealed that human studies evaluating the efficacy of ED-S ingredients are limited and have yielded no definitive findings of the effects on ED.
In plain English: Supplementation of Physta® at 200 mg was able to increase the serum total testosterone, reduce fatigue and improve the quality of life in ageing men within 2 weeks' time.
Chinnappan SM et al. · Food & Nutrition Research (2021)
Significant increase in total testosterone at week 12 (Physta 100 mg) and at weeks 4, 8 and 12 (Physta 200 mg) versus placebo.
Ageing Male Symptoms and Fatigue Severity Scale scores significantly reduced in both Physta groups; muscle strength significantly increased at week 12.
Cortisol significantly decreased in the Physta 200 mg group; no safety-related clinically relevant changes were observed.
11Ethnobotany and pharmacological propertiesReview2010
In plain English: The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and pasakbumin-B) among which the alkaloids and quassinoids form a major p...
Bhat R et al. · Fitoterapia (2010)
The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and pasakbumin-B) among which the alkaloids and quassinoids form a major portion.
Even though toxicity and safety evaluation studies have been pursued, still a major gap exists in providing scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumer's safety.
The present review aims at reviewing the research works undertaken till date, on this plant in order to provide sufficient baseline information for future works and for commercial exploitation.
17Sperm quality and pregnancy rateOpen-Labeln=75 · small study2010
In plain English: The proprietary extract of Eurycoma longifolia Jack significantly improved the sperm quality in these patients, allowing for 11 (14.7%) spontaneous pregnancies.
Tambi MI et al. · Asian Journal of Andrology (2010)
Follow-up semen analyses showed significant improvement in all semen parameters (semen volume, sperm concentration, normal morphology, and motility).
350 men with idiopathic infertility received 200 mg/day of the standardized extract; 75 completed one full 3-month cycle.
Treatment allowed for 11 (14.7%) spontaneous pregnancies.