Tka7.0

Tongkat Ali Research

15 peer-reviewed studies · Evidence score: 7/10

Effect of Tongkat Ali (Eurycoma longifolia) supplementation on physical function and testosterone among aging men: A systematic review

Leisegang K et al. • Phytotherapy Research (2022)

Tongkat Ali supplementation consistently elevated testosterone levels and improved physical function markers including grip strength and muscular endurance in aging men.

Consistent elevation of free and total testosterone levels across clinical studies
Improved physical function including grip strength and muscular endurance
Positive effects on body composition with reduced body fat percentage

Systematic Reviewn=410

DOI

[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)]

Ye DN et al. • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2024)

This study aims to facilitate the compatible use and product development of Tongkat Ali while providing reference for introducing it as a new TCM resource and studying the TCM properties of ginseng plants abroad.

Tongkat Ali has the main functions of tonifying kidney and replenishing essence, invigorating spleen and replenishing Qi, and soothing liver and relieving depression.
The recommended dosage and usage of this medicine are 2-10 g daily and decoction with water, respectively.
This study aims to facilitate the compatible use and product development of Tongkat Ali while providing reference for introducing it as a new TCM resource and studying the TCM properties of ginseng plants abroad.

Systematic Review

DOI

Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials

Kotirum S et al. • Complementary therapies in medicine (2015)

Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function.

No significance between group difference was found in the mean WMD of the change in the 5- item version of the international index of erectile function (IIEF-5) at week-12 (0.91; 95% CI: -1.50 to 3.33 with I(2)=89.5%, P-value=0.002) with statistical heterogeneity.
Based on the subgroup analysis, significant improved IIEF-5 score of 2.15 (95% CI 1.03-3.27) was found in subjects with lower baseline IIEF-5 score, but this was not seen among those with higher baseline IIEF-5 score.
Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function.

Meta-Analysisn=139

DOI

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials

Leisegang K et al. • Medicina (Kaunas, Lithuania) (2022)

Although more research is required before its use in clinical practice, this may represent a safe and promising therapeutic option, particularly in hypogonadal men.

A significant improvement in total testosterone levels after E. longifolia treatment was mostly reported in both healthy volunteers and hypogonadal men.
The random model effect revealed a significant increase (SMD = 1.352, 95% CI 0.565 to 2.138, p = 0.001) in the total testosterone levels in men receiving E. longifolia supplementation, which was confirmed in the hypogonadism subgroup.
Conclusions: This systematic review and meta-analysis of the literature supports the possible use of E. longifolia supplementation for enhancing testosterone production.

Meta-Analysis

DOI

An Analysis of Popular Online Erectile Dysfunction Supplements

Balasubramanian A et al. • The journal of sexual medicine (2019)

Our investigation revealed that human studies evaluating the efficacy of ED-S ingredients are limited and have yielded no definitive findings of the effects on ED.

Our literature review identified 413 studies involving the 21 identified ingredients, of which 59 (16%) involved human subjects.
Among these 69 human studies, only 12 (17%) investigated supplement ingredients individually and reported improvement in ED.
Our investigation revealed that human studies evaluating the efficacy of ED-S ingredients are limited and have yielded no definitive findings of the effects on ED.

Systematic Reviewn=21

DOI

Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies

Thu HE et al. • Chinese journal of natural medicines (2017)

In summary, there is convincing evidence for the prominence of EL in improving the male sexual health.

In summary, there is convincing evidence for the prominence of EL in improving the male sexual health.
The review also substantiates the use of current methodology in the development of novel and more rationale natural herbal medicines for the management of male sexual disorders.

Systematic Review

DOI

Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy

George A et al. • Andrologia (2014)

Therefore, TA might be a safe alternative to TRT.

The testosterone deficiency syndrome (TDS) is characterised by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males' symptoms.
This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40-50% lower in men older than 60 years compared with young men.
Eurycoma longifolia (Tongkat Ali; TA) is natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health.

Systematic Review

DOI

An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration

Ulbricht C et al. • Journal of dietary supplements (2013)

This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale.
This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Further research warranted to confirm findings

Systematic Review

DOI

Eurycoma longifolia (Tongkat Ali): A Systematic Review of Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

Rehman SU et al. • Molecules (2016)

Tongkat Ali demonstrated consistent anti-estrogenic, pro-androgenic, and ergogenic effects with a favorable safety profile across clinical and preclinical studies.

Pro-androgenic effects through multiple mechanisms including aromatase inhibition
Ergogenic properties supported by both animal models and human clinical trials
Favorable safety profile at standard supplemental doses (200-400mg/day)

Systematic Review

DOI

Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance

Bhat R et al. • Fitoterapia (2010)

The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and pasakbumin-B) among which the alkaloids and quassinoids form a major p...

The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and pasakbumin-B) among which the alkaloids and quassinoids form a major portion.
Even though toxicity and safety evaluation studies have been pursued, still a major gap exists in providing scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumer's safety.
The present review aims at reviewing the research works undertaken till date, on this plant in order to provide sufficient baseline information for future works and for commercial exploitation.Copyright © 2010 Elsevier B.V.

Systematic Review

DOI

Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack--A Randomized, Double-Blind, Placebo-Controlled, Parallel Study

George A et al. • Phytotherapy research : PTR (2016)

The numbers of total, naïve, and CD4(+) T cells were also higher in the TA group than those in P group (p < 0.05).

The numbers of total, naïve, and CD4(+) T cells were also higher in the TA group than those in P group (p < 0.05).
No severe adverse events were observed.
The results suggest that ingestion of the root water extract of TA (Physta®) enhances comprehensive immunity in both middle-aged men and women.

RCTn=126

DOI

A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM)

Leitão AE et al. • Maturitas (2021)

The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.

The combination of Eurycoma longifolia and concurrent training improved erectile function and increased total testosterone levels in men with ADAM.
Further research warranted to confirm findings

RCTn=45

DOI