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Txa6.0

Tranexamic Acid (topical) Research

Mostly mechanism / observational

1,003 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Tranexamic Acid (topical) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 2014–2026 with a typical study size of 50 participants.

Based on 1,003 studies · 380 meta-analyses · 559 RCTs · 50 total participants

Confidence

High confidence

By outcome

Heart & blood pressure
Mostly mechanism / observational98 studies
Skin tone & pigmentationReduction in melasma/stubborn pigmentation, comparable to hydroquinone in small trials (cosmetic, not a health outcome) · 8-12 weeks
Mostly mechanism / observational66 studies
Therapeutic & clinical
Mostly mechanism / observational34 studies
Anemia & hematology
Mostly mechanism / observational11 studies
Recovery
Mostly mechanism / observational7 studies
Men's vitality
Mostly mechanism / observational6 studies
Safety profile
Mostly mechanism / observational6 studies
Skin health
Mostly mechanism / observational5 studies

10 more outcomes with fewer studies not shown.

Active research area

739 studies in the last 5 years · Latest meta-analysis: 2026

201420202026

1Meta-Analysis2026

Xue X, Zhuang X, Zhou X, Zhu W, Lou J, Yang X · Arthroscopy (2026)

Tranexamic Acid (topical) Research

Mostly mechanism / observational

Tranexamic Acid Reduces Bleeding and Early Pain but Does Not Improve Intraoperative Visualization in Arthroscopic Rotator Cuff Repair: A Systematic Review and Meta-analysis.

Efficacy and Safety of Combined Carbazochrome Sodium Sulfonate and Tranexamic Acid for Blood Loss Control in Patients Undergoing Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.

Safety and Efficacy of Tranexamic Acid in Hepatic Surgery: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Effects of tranexamic acid in patients undergoing liver surgeries: an updated meta-analysis of randomized-controlled trials.

Effectiveness of Prophylactic Doses of Tranexamic Acid in Reducing Hemorrhagic Events in Bariatric Surgery: A Systematic Review and Meta-Analysis.

Effects of Ulinastatin and Tranexamic Acid in Cardiac Surgery: A Systematic Review and Meta-Analysis.

Perioperative tranexamic acid in burn surgery: systematic review and meta-analysis of randomized controlled trials.

Tranexamic acid to prevent bleeding in patients with hematologic malignancies and hypoproliferative thrombocytopenia: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.

Efficacy and Safety of Oral versus Intravenous Administration of Tranexamic Acid in Elective Total Hip Arthroplasty: A Systematic Review and Meta-Analyses of Randomized Controlled Trials.

The use of tranexamic acid in external dacryocystorhinostomy: a systematic review and meta-analysis of randomized controlled trials.

Assessing current applications of tranexamic acid in reconstructive microsurgery and future direction: An 11-year meta-analysis.

Perioperative Use of Tranexamic Acid in General Surgery: A Systematic Review and Meta-Analysis.

The Effects of Tranexamic Acid on Renal Outcomes in Patients Undergoing Cardiovascular Surgery: A Systematic Review and Meta-Analysis Compliant With Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Efficacy and Safety of Tranexamic Acid Use in Bariatric Surgery: An Updated Systematic Review and Meta-Analysis.

Affordable Excellence: A Meta-Analysis on the Efficacy of Topical Tranexamic Acid in Reducing Blood Loss in Thoracolumbar Spinal Surgery.

Equivalence of oral and intravenous tranexamic acid in knee arthroplasty: a systematic review and meta-analysis of randomized clinical trials.

Impact of Tranexamic Acid in Breast Plastic Surgery: A Systematic Review and Meta-Analysis.

Tranexamic Acid in Men Undergoing Transurethral Resection of Prostate: An Updated Systematic Review and Meta-Analysis.

Tranexamic acid for spontaneous intracerebral hemorrhage: hematoma control without clinical benefits? A meta-analysis of RCTs.

The efficacy and safety of high versus low doses of intravenous intraoperative tranexamic acid during spinal fusion in patients with adolescent idiopathic scoliosis: a network meta-analysis of randomized controlled trials.