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Tm6.0
Tremella Research
Mostly mechanism / observationalHigh safety
14 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Tremella studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2012–2026 with a typical study size of 60 participants.
Based on 14 studies · 3 RCTs · 181 total participants
Immune supportEnhanced immune function · 4-8 weeks
Mostly mechanism / observational10 studies
Cognitive function
Mostly mechanism / observational5 studies
Inflammation
Mostly mechanism / observational5 studies
Therapeutic & clinical
Mostly mechanism / observational4 studies
Glucose & metabolic
Mostly mechanism / observational3 studies
Neuroprotection & brain aging
Too few graded studies2 studies
Digestive health
Too few graded studies1 study
Safety profile
Too few graded studies1 study
By the numbers
Pulled from 11 studies with measurable effects
People studied
181
typical study: 60 people
Strongest designs
3
0 pooled, 3 randomised
Showed benefit
100%
2/2 studies
How long studies ran
1–4 weeks
1
Populations Studied
Patients with neurological disorders1
Not specified1
Skin cells1
Multiple sub-health states1
Active research area
8 studies in the last 5 years
201220192026
1Neuroprotection against infectionsSystematic Review2026
This review explores for the first time the complex interplay between infections and neurological disorders, highlighting the potential of mushrooms not only as functional foods but also as complem...
Buttacavoli M et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2026)
This review explores for the first time the complex interplay between infections and neurological disorders, highlighting the potential of mushrooms not only as functional foods but also as complementary allies in safeguarding brain health.
Additionally, it provides a theoretical basis for the potential applications of TFP in the food, pharmaceutical, and cosmetic industries, while also discussing future research directions and development prospects.
Rui Y et al. · Journal of food science (2025)
Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory, hypoglycemic, and hypolipidemic effects, as well as skin-protective properties and gut microbiota modulation.
Due to these multifunctional properties, TFP has garnered considerable attention in the food, pharmaceutical, and cosmetic industries.
This review summarizes recent research on TFP, focusing on its preparation methods, structural characteristics, and diverse biological activities.
3Anti-aging effects of macrofungal extracts on skinSystematic ReviewCited 20×2024
According to available literature data, macrofungi contain many polysaccharides, phenolic compounds, polysaccharide peptides, free amino acids, sterols, proteins, glycosides, triterpenes, alkaloids, which can have an anti-aging effect on the skin by acting as antioxidants, photoprotective, skin whitening, moisturizing, anti-inflammatory and stabilizing collagen, elastin and hyaluronic acid levels in the skin.
Paterska M et al. · Nutrients (2024)
To slow down this process, natural anti-aging skincare ingredients are being sought.
In this review, 52 scientific publications about the effects of chemical compounds extracted from the fruiting bodies of macrofungi on skin cells were selected.
The effects of extracts from nine species that are tested for anti-aging effects have been described.
4Tremella polysaccharide production and applicationsSystematic ReviewCited 57×2021
The application prospect of Tremella polysaccharide in against multiple sub-health states was worth expecting.
Ma X et al. · International journal of immunopathology and pharmacology (2021)
Tremella polysaccharide is known to be structurally unique and biologically active natural products, abundant and versatile in activities and applications in food industry, daily chemical industry and medicine industry.
In order to improve the industrialisation of Tremella polysaccharide, the limitations of preparation and structure-activity relationship of Tremella polysaccharide were reviewed in this paper.
The research progress of Tremella polysaccharide in the past 20 years was summarized from the sources, preparation methods, molecular structure, activity and application, and the research trend in the future was also prospected.
5Tremella polysaccharide drug action mechanismsSystematic ReviewCited 37×2019
In this chapter, 113 independent studies involving in biochemical, pharmacological, and clinical studies of TFPS during the past 46 years (1972-2018) on the base of PubMed, CNKI (China National Kno...
Yang D et al. · Progress in molecular biology and translational science (2019)
In this chapter, 113 independent studies involving in biochemical, pharmacological, and clinical studies of TFPS during the past 46 years (1972-2018) on the base of PubMed, CNKI (China National Knowledge Infrastructure) and Wanfang database search are summarized.
TFPS shows efficacy for all types of human diseases in the reported clinical studies.
The structure, molecular mechanisms of the immunomodulation, antitumor, anti-oxidation, anti-aging, hypoglycemic, hypolipidemic, preclinical and clinical efficacy are discussed to provide a general picture of TFPS as a clinically used drug.
6Bioactivities of Tremella fuciformis polysaccharidesSystematic ReviewCited 113×2019
In the past decades, many researchers have reported that T. fuciformis polysaccharides (TPS) possess various bioactivities, including anti-tumor, immunomodulatory, anti-oxidation, anti-aging, repai...
Wu YJ et al. · International journal of biological macromolecules (2019)
In the past decades, many researchers have reported that T. fuciformis polysaccharides (TPS) possess various bioactivities, including anti-tumor, immunomodulatory, anti-oxidation, anti-aging, repairing brain memory impairment, anti-inflammatory, hypoglycemic and hypocholesterolemic.
The structural characteristic of TPS has also been extensively investigated using advanced modern analytical technologies such as NMR, GC-MS, LC-MS and FT-IR to dissect the structure-activity relationship (SAR) of the TPS biomacromolecule.
This article reviews the recent progress in the extraction, purification, structural characterization and applications of TPS.
This formula beverage is a promising option that could be used to prevent further cognitive decline in adults with subjective cognitive complaints.
Lin YK et al. · Nutrients (2023)
After 4 and 8 weeks, there was a significant increase in the number of memory cards, and the response times among those who consumed the formula beverage were significantly faster than those in the placebo group.
There was a significant increase in the cue effect of happy facial expressions after the subjects consumed the formula beverage for 8 weeks.
In addition, there was a significant decrease in anxiety and fatigue, and improved quality of life.
The current findings suggest that TF could be safely administered to relieve subjective memory complaints and enhance cognition in individuals with SCI.
Ban S et al. · Journal of medicinal food (2018)
Overall frequency of adverse events did not differ among high-dose TF (40.4%), low-dose TF (35.1%), and placebo groups (41.4%).
There were also significantly greater improvements in short-term memory and executive functions in the TF group relative to the placebo group.
Exploratory analysis demonstrated that there were significant group-by-visit interactions on the left precuneus, right supramarginal gyrus, right middle frontal gyrus, and right postcentral gyrus at corrected P < .05.
This review is intended to provide a theoretical basis for the further investigation and application of TFPs in cosmetics, functional foods, beverages, and healthcare products.
Luan F et al. · International journal of biological macromolecules (2026)
In this review, we provide a comprehensive overview of the extraction, purification, structural characteristics, pharmacological properties, and underlying mechanisms of TFPs.
In addition, the structure-activity relationships, potential applications, safety evaluation, and modification strategies associated with their bioactivities are highlighted, together with a discussion of future research directions.
This review is intended to provide a theoretical basis for the further investigation and application of TFPs in cosmetics, functional foods, beverages, and healthcare products.
Tremella fuciformis polysaccharides have great prospects but lack clarity on some mechanisms, higher-order structure research, and standardized quality criteria.
Liao Y et al. · Carbohydrate research (2026)
Huge benefit
← WorseNo effectBetter →
Tremella fuciformis polysaccharides have diverse extraction methods (hot water, ultrasonic/microwave-assisted, etc.), with composite tech boosting yield over 50%.
Tremella fuciformis polysaccharides have great prospects but lack clarity on some mechanisms, higher-order structure research, and standardized quality criteria.
With deeper study, they may bring new breakthroughs in industries of health maintenance, disease treatment, and cosmetics and skincare.
14Immunomodulatory and anticancer activitiesObservationalCited 27×2015
Taken together, our results indicated that T1 and T6 strains of TFs showed the similar immune modulatory and anticancer abilities were better than the CH strain of TFs.
Han CK et al. · The American journal of Chinese medicine (2015)
On the other hand, the cold water extracts of TFs, especially of T1C, obviously suppressed cancer cell survival better than those of hot water extracts.
Interestingly, we found that hot water extracts of TFs may augment necrotic cell death, whereas, cold water extracts of TFs induce apoptosis.
Furthermore, we also showed that these TFs activate caspase-3 cleavage, up regulate the Bax/Bcl-2 ratio, and decrease MMP-9 expressions in PC-3 cells.