Tm6.0

Tremella Research

18 peer-reviewed studies · Evidence score: 6/10

Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms

Buttacavoli M et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2026)

This review explores for the first time the complex interplay between infections and neurological disorders, highlighting the potential of mushrooms not only as functional foods but also as complem...

This review explores for the first time the complex interplay between infections and neurological disorders, highlighting the potential of mushrooms not only as functional foods but also as complementary allies in safeguarding brain health.

Systematic Review

DOI

Detection methods and control measures of Burkholderia gladioli and its toxins: A review

Gao B et al. • Journal of food science (2025)

This review will help to comprehensively understand the spread of B. gladioli and its toxins and preventive measures, aiming to reduce their harm to human health.

First, this article summarizes the clinical cases and prevalence caused by B. gladioli.
Second, the detection methods for BKA and the methods for simultaneous detection of BKA and TF were reviewed.
Finally, the methods that can inhibit the proliferation of B. gladioli and effective measures to control its production of BKA in different food carriers were reviewed.

Systematic Review

DOI

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review

Rui Y et al. • Journal of food science (2025)

Additionally, it provides a theoretical basis for the potential applications of TFP in the food, pharmaceutical, and cosmetic industries, while also discussing future research directions and development prospects.

Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory, hypoglycemic, and hypolipidemic effects, as well as skin-protective properties and gut microbiota modulation.
Due to these multifunctional properties, TFP has garnered considerable attention in the food, pharmaceutical, and cosmetic industries.
This review summarizes recent research on TFP, focusing on its preparation methods, structural characteristics, and diverse biological activities.

Systematic Review

DOI

Forensic Research Progress on Bongkrekic Acid Poisoning

Chen XL et al. • Fa yi xue za zhi (2025)

This article reviews the autopsy cases and literature of deaths caused by BA poisoning at home and abroad, systematically summarizes the epidemiology, clinical manifestations, pathological changes, toxicological mechanisms, detection methods, forensic diagnostic key points and challenges of BA in forensic medicine, with the aim of providing a reference for forensic identification of related cases.

At present, there is still a lack of complete method to detect BA, and no specific antidote of BA has been found.
Therefore, BA poisoning is easy to be misdiagnosed or missed diagnosed, and its mortality rate remains high.
In recent years, studies have revealed the toxic mechanism of BA and found that BA can inactivate some enzymes containing thiol groups (-SH) and inhibit the synthesis and transport of adenosine triphosphate (ATP), causing damage to liver, kidney, brain and other parenchymal organs.

Systematic Review

DOI

Macrofungal Extracts as a Source of Bioactive Compounds for Cosmetical Anti-Aging Therapy: A Comprehensive Review

Paterska M et al. • Nutrients (2024)

According to available literature data, macrofungi contain many polysaccharides, phenolic compounds, polysaccharide peptides, free amino acids, sterols, proteins, glycosides, triterpenes, alkaloids, which can have an anti-aging effect on the skin by acting as antioxidants, photoprotective, skin whitening, moisturizing, anti-inflammatory and stabilizing collagen, elastin and hyaluronic acid levels in the skin.

To slow down this process, natural anti-aging skincare ingredients are being sought.
In this review, 52 scientific publications about the effects of chemical compounds extracted from the fruiting bodies of macrofungi on skin cells were selected.
The effects of extracts from nine species that are tested for anti-aging effects have been described.

Systematic Review

DOI

A review on the production, structure, bioactivities and applications of Tremella polysaccharides

Ma X et al. • International journal of immunopathology and pharmacology (2021)

The application prospect of Tremella polysaccharide in against multiple sub-health states was worth expecting.

Tremella polysaccharide is known to be structurally unique and biologically active natural products, abundant and versatile in activities and applications in food industry, daily chemical industry and medicine industry.
In order to improve the industrialisation of Tremella polysaccharide, the limitations of preparation and structure-activity relationship of Tremella polysaccharide were reviewed in this paper.
The research progress of Tremella polysaccharide in the past 20 years was summarized from the sources, preparation methods, molecular structure, activity and application, and the research trend in the future was also prospected.

Systematic Review

DOI

Tremella polysaccharide: The molecular mechanisms of its drug action

Yang D et al. • Progress in molecular biology and translational science (2019)

In this chapter, 113 independent studies involving in biochemical, pharmacological, and clinical studies of TFPS during the past 46 years (1972-2018) on the base of PubMed, CNKI (China National Kno...

In this chapter, 113 independent studies involving in biochemical, pharmacological, and clinical studies of TFPS during the past 46 years (1972-2018) on the base of PubMed, CNKI (China National Knowledge Infrastructure) and Wanfang database search are summarized.
TFPS shows efficacy for all types of human diseases in the reported clinical studies.
The structure, molecular mechanisms of the immunomodulation, antitumor, anti-oxidation, anti-aging, hypoglycemic, hypolipidemic, preclinical and clinical efficacy are discussed to provide a general picture of TFPS as a clinically used drug.

Systematic Review

DOI

Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review

Wu YJ et al. • International journal of biological macromolecules (2019)

In the past decades, many researchers have reported that T. fuciformis polysaccharides (TPS) possess various bioactivities, including anti-tumor, immunomodulatory, anti-oxidation, anti-aging, repai...

In the past decades, many researchers have reported that T. fuciformis polysaccharides (TPS) possess various bioactivities, including anti-tumor, immunomodulatory, anti-oxidation, anti-aging, repairing brain memory impairment, anti-inflammatory, hypoglycemic and hypocholesterolemic.
The structural characteristic of TPS has also been extensively investigated using advanced modern analytical technologies such as NMR, GC-MS, LC-MS and FT-IR to dissect the structure-activity relationship (SAR) of the TPS biomacromolecule.
This article reviews the recent progress in the extraction, purification, structural characterization and applications of TPS.Copyright © 2018 Elsevier B.V.

Systematic Review

DOI

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Lin YK et al. • Nutrients (2023)

This formula beverage is a promising option that could be used to prevent further cognitive decline in adults with subjective cognitive complaints.

After 4 and 8 weeks, there was a significant increase in the number of memory cards, and the response times among those who consumed the formula beverage were significantly faster than those in the placebo group.
There was a significant increase in the cue effect of happy facial expressions after the subjects consumed the formula beverage for 8 weeks.
In addition, there was a significant decrease in anxiety and fatigue, and improved quality of life.

RCTn=32

DOI

Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial

Ban S et al. • Journal of medicinal food (2018)

The current findings suggest that TF could be safely administered to relieve subjective memory complaints and enhance cognition in individuals with SCI.

Overall frequency of adverse events did not differ among high-dose TF (40.4%), low-dose TF (35.1%), and placebo groups (41.4%).
There were also significantly greater improvements in short-term memory and executive functions in the TF group relative to the placebo group.
Exploratory analysis demonstrated that there were significant group-by-visit interactions on the left precuneus, right supramarginal gyrus, right middle frontal gyrus, and right postcentral gyrus at corrected P < .05.

RCTn=75

DOI

Advances in extraction, structural characteristics, bioactivities, structure-activity relationship, quality control and applications of polysaccharides from Tremella fuciformis: A review

Liao Y et al. • Carbohydrate research (2026)

Tremella fuciformis polysaccharides have great prospects but lack clarity on some mechanisms, higher-order structure research, and standardized quality criteria.

Tremella fuciformis polysaccharides have diverse extraction methods (hot water, ultrasonic/microwave-assisted, etc.), with composite tech boosting yield over 50%.
Tremella fuciformis polysaccharides have great prospects but lack clarity on some mechanisms, higher-order structure research, and standardized quality criteria.
With deeper study, they may bring new breakthroughs in industries of health maintenance, disease treatment, and cosmetics and skincare.

Systematic ReviewAI-discovered

DOI

Mushrooms and Their Bioactive Ingredients as Natural Resources for Development of Innovative Skin Care Formulations and Products

Janardhanan KK et al. • International journal of medicinal mushrooms (2026)

This review outlines the importance of mushrooms and their bioactive ingredients for development of skin care formulations and products in the multibillion-dollar cosmetic industry.

Mushroom based cosmetic products have substantial world market especially in USA, China, UK, Korea and Japan.
Mushroom cosmetic market presents promising opportunities for expansion because of the growing demands of aging solutions.
Global demand is predicted to reach nearly 3.9 billion USD by 2032.

Systematic ReviewAI-discovered

DOI

Yellow brain culinary-medicinal mushroom, Tremella mesenterica Ritz.:Fr. (higher Basidiomycetes), is subjectively but not objectively effective for eradication of Helicobacter pylori: a prospective controlled trial

Lachter J et al. • International journal of medicinal mushrooms (2012)

Significant symptomatic relief found among Tm-treated patients suggests that further study of Tm is well justified.

The patients who took the standard triple therapy had a 70% (n = 14) eradication rate of Hp.
Limitations of this study include the brief duration of Tm therapy.
Longer treatment might achieve better results, but was judged to be not warranted, so as to not excessively further delay accepted therapy.

RCTn=14

DOI

Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles used for androgenic alopecia

Liu Y et al. • Stem cell research & therapy (2025)

These results indicate that Mag-IVs and tremella polysaccharide can synergistically improve the hair microenvironment, which has a promising future for AGA treatment.

These results indicate that Mag-IVs and tremella polysaccharide can synergistically improve the hair microenvironment, which has a promising future for AGA treatment.
Further research warranted to confirm findings

Observational

DOI

Injectable natural Tremella-derived hydrogel for reversing ferroptosis-mediated osteoporotic microenvironment imbalance and promoting osteoregeneration

Ye C et al. • Biomaterials (2026)

Moreover, OGP@DTrep increases the intracellular antioxidant capacity, inhibits osteoblast ferroptosis, and enhances bone matrix secretion.

Moreover, OGP@DTrep increases the intracellular antioxidant capacity, inhibits osteoblast ferroptosis, and enhances bone matrix secretion.
In a rat model of osteoporotic bone defects, it reversed iron metabolism imbalance, restoring bone mass and microstructure.
This study presents a naturally derived biomaterial with multiple activities, such as a ROS response and iron metabolism regulation, offering a new perspective for treating osteoporotic bone defects and other bone diseases.

Observational

DOI

Risk factors for the formation of striae gravidarum in women in Jiangsu Province of China

Ren P et al. • Taiwanese journal of obstetrics & gynecology (2019)

The lifestyle and eating habits have a certain influence on the formation and severity of stretch marks.

The lifestyle and eating habits have a certain influence on the formation and severity of stretch marks.
Further research warranted to confirm findings

Observationaln=400

DOI

Tremella-like graphene-Au composites used for amperometric determination of dopamine

Li C et al. • The Analyst (2015)

Moreover, the modified electrode was applied to the determination of DA in human urine and serum samples.

The t-GN-Au composites were directly used for the determination of DA via cyclic voltammetry (CV) and the chronoamperometry (CA) technique.
CA measurement gave a wide linear range from 0.8 to 2000 μM, and the detection limit of 57 nM (S/N = 3) for DA.
The mechanism and the heterogeneous electron transfer kinetics of the DA oxidation were discussed in the light of rotating disk electrode (RDE) experiments.

Observational

DOI

Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk

Han CK et al. • The American journal of Chinese medicine (2015)

Taken together, our results indicated that T1 and T6 strains of TFs showed the similar immune modulatory and anticancer abilities were better than the CH strain of TFs.

On the other hand, the cold water extracts of TFs, especially of T1C, obviously suppressed cancer cell survival better than those of hot water extracts.
Interestingly, we found that hot water extracts of TFs may augment necrotic cell death, whereas, cold water extracts of TFs induce apoptosis.
Furthermore, we also showed that these TFs activate caspase-3 cleavage, up regulate the Bax/Bcl-2 ratio, and decrease MMP-9 expressions in PC-3 cells.

Observational

DOI

View in Research Library